K. Wang

The paper identifies simeprevir as a potent inhibitor of SARS-CoV-2 replication that synergizes with remdesivir in vitro.

Overexpression of VDAL in Arabidopsis enhances resistance to Verticillium dahliae by preventing degradation of the transcription factor MYB6 through interaction with PUB25/26 E3 ligases.

The paper investigates how RNA-binding proteins (RBPs) influence RNA polymerase II activity through phase separation, showing that RBPs like PSPC1 enhance polymerase engagement and transcription.

This study shows that knocking down PxRdl2 with dsRNA enhances the insecticidal effects of GABAR-targeting compounds against Plutella xylostella.

The paper demonstrates direct spleen-vagus communication by using Pt-rGO fiber electrodes to record activity in splenic nerve terminal branches and show functional compartmentalization.

This study identifies UBXN3B's critical role in B lymphopoiesis by maintaining BLNK stability and pre-BCR signaling, leading to impaired B cell development and increased vulnerability to viral infections.

The paper analyzes T-cell receptor repertoires in different phases of COVID-19 to identify immune response patterns and predict recurrent infection risk.

This paper identifies SAM competitive inhibitors of SARS-CoV-2 nsp14 methyltransferase and characterizes their mechanism, guiding the development of selective bi-substrate inhibitors.

This study identifies key genes in the polyphyllin biosynthetic pathway using transcriptome and metabolome data combined with phylogenetic analysis.

This study evaluates the neutralization sensitivity of SARS-CoV-2 variants N501Y.V1 and N501Y.V2 to convalescent sera and monoclonal antibodies, finding reduced neutralization activity.

This study shows STING agonists reduce cancer pain and bone destruction in mouse models by modulating neurons, immune cells, and osteoclasts.

This study shows that adenovirus injection in mice causes prolonged macrophage mobilization in the anterior chamber, suggesting potential confounding effects in ocular research.

This study identifies the structural and molecular mechanisms of two neutralizing antibodies against FMDV, showing they disrupt virus-receptor interactions and provide prophylactic and therapeutic benefits.

The paper examines HDP gene expression and tissue distribution in different chicken breeds, finding correlations between body weight, age, and HDP expression in immune organs and intestine.

This study shows GSTZ1 enhances sorafenib-induced ferroptosis in HCC by inhibiting the NRF2/GPX4 axis, and its deficiency leads to resistance to sorafenib.

This study identifies bis-benzylisoquinoline alkaloids as SARS-CoV-2 entry inhibitors through in vitro screening of natural products.

The paper introduces SigPath, a mass spectrometry assay that quantifies 284 phosphosites across 200 phosphoproteins, revealing new insights into phospho-signaling in cancer models and human tumors.

This study uses single-cell multi-omics to identify lineage plasticity and stem-cell-like blasts in KMT2A-rearranged leukemia, linking these features to poor prognosis in infants.

The paper identifies two independent parental contributions to zygote polarization in Arabidopsis thaliana, involving maternal ERECTA and paternal SHORT SUSPENSOR (SSP) in activating the YDA MAP kinase pathway.

This paper identifies a cyclic phosphoramidate prodrug that shows anti-dengue activity in vitro and in vivo but is suspended due to toxicity concerns.

This study investigates how H3K9 acetylation modification affects TLR9 expression and immune response in patients treated with thymosin a1 and entecavir for hepatitis B.

This paper introduces spatially expandable fiber-based probes for deep brain interface, enabling three-dimensional recording and stimulation of neural activity with high resolution and minimal tissue damage.

CancerVar scores and classifies somatic mutations into four tiers using a rule-based system and a deep learning model, improving interpretation of both known and novel mutations in cancer.

This study identifies a linear epitope on SARS-CoV-2 S-RBD recognized by a potent neutralizing antibody and shows its potential for vaccine design.

This study identifies PFKM as a direct target of celastrol, showing that its inhibition promotes weight loss and leptin sensitivity through AMPK/ACC signaling.

The paper generates thymidine auxotrophic Agrobacterium tumefaciens strains for plant transformation and confirms their functionality.

This paper introduces a rapid screening system to identify potent neutralizing antibodies against SARS-CoV-2 and demonstrates its effectiveness in discovering high-potency antibodies.

This study shows that PCK1 deficiency increases O-GlcNAcylation and promotes HCC growth under glucose deprivation by enhancing CHK2 activity.

This study integrates multi-omic data from COVID-19 patients to identify immune response patterns linked to disease severity.