K. Wang

The paper introduces siEVPRA, a method to detect proteins, mRNAs, and miRNAs in single EVs using fluorescence microscopy, showing high sensitivity and clinical utility in GBM samples.

This study characterizes PcoB, an outer membrane protein that facilitates copper import, revealing its structure and function in Cu homeostasis and defense against metal stress.

This paper develops an ultra-small bispecific fusion protein, Bi-fp50, that improves tumor penetration and treatment efficacy for pancreatic cancer by targeting EGFR and VEGF.

This study shows that mice lacking TG synthesis enzymes in adipose tissue are metabolically healthy and resistant to diet-induced obesity despite reduced TG storage.

This paper identifies a potent antibody cocktail that synergistically neutralizes SARS-CoV-2 and its variants, including Omicron BA.1 and BA.2.

This study identifies RipAF1 as an effector that ADP-ribosylates host FBN1, inducing resistance against bacterial wilt by disrupting disease signaling.

This paper develops compact human mechanosensitive TADs for synthetic transcriptional control, showing they are potent, versatile, and well-tolerated in primary cells.

This study characterizes the structural and functional properties of two multimodular triphosphosphate tunnel metalloenzymes in Arabidopsis thaliana, revealing their roles in developmental transitions.

This study shows that an Omicron-specific subunit vaccine booster enhances neutralizing antibodies against SARS-CoV-2 variants and the ancestral virus, with a two-dose WT-RBD plus Omicron-RBD booster showing the strongest response.

The paper develops a pipeline to measure exchange rates and concentrations of amide and arginine guanidinium protons in the mouse brain using CEST and validates it with specific mouse models.

The paper characterizes structural and functional changes in the SARS-CoV-2 Omicron variant's Spike protein, identifying new immune escape sites and providing insights for vaccine development.

Antibodies from 3-dose vaccinated individuals neutralize Omicron and other variants, with some being ultrapotent and broadly reactive.

This study assesses the infectivity and immune evasion of the Omicron SARS-CoV-2 variant using pseudotyped viruses and neutralizing assays against convalescent sera and vaccinated individuals.

This study shows that UTX promotes glioblastoma progression by upregulating periostin expression, and its knockdown inhibits tumor growth and promotes apoptosis.

This study shows that Ser68 phosphorylation is essential for CENP-A deposition, centromere function, and mouse viability.

The paper shows that chromosome 1q amplification promotes melanoma metastasis by overexpressing ceRNAs that sequester tumor suppressor miRNAs.

This study shows that Hoxb5 can convert multipotent blood progenitors into hematopoietic stem cell-like cells with long-term repopulating ability.

This paper reviews 73 mammalian models of the cardiac L-type calcium current, finds large variability in their predictions, and provides model code and data sources.

This paper shows metformin reduces anxiety and depression-like symptoms in mice during methamphetamine withdrawal by modulating gut microbiota-derived inosine.

This study shows that CD147 antibody inhibits SARS-CoV-2 infection and cytokine storm in variants by blocking viral entry and reducing inflammatory responses.

This study characterizes the interaction of Taphrina strain M11 with Arabidopsis thaliana, showing it is pathogenic and activates cytokinin signaling while requiring jasmonate and ethylene for immunity.

This paper develops a mathematical model of autoimmune myocarditis and shows how immune checkpoint inhibitors increase its risk.

The paper identifies a high-risk Multiple Myeloma subgroup using multi-omics data, linking genomic loss to dysregulated DNA repair and cell cycle pathways.

The paper presents structures and functional analyses of a PIB-4-type ATPase, revealing novel mechanisms of heavy-metal transport and potential drug targets.

This study simulates reentrant arrhythmias in ischemic hearts with multiple electrophysiological remodelling stages, showing that spatial heterogeneity of refractory periods and excitation threshold differences drive reentry depending on border orientation relative to wavefronts.

This study shows Brsk2 amplifies parasympathetic signals to promote type 2 diabetes by enhancing β-cell insulin secretion in obese mice and associates human BRSK2 variants with metabolic disorders.

This paper improves image resolution and signal-to-noise ratio in live cell imaging using a combination of discrete wavelet transform and Lucy-Richardson deconvolution.

The paper evaluates the neutralization efficacy of inactivated and RBD-subunit vaccines against SARS-CoV-2 B.1.617 and B.1.1.7 variants using a pseudovirus-based assay.

This study constructs high-resolution spatial transcriptomes of primary liver cancers to analyze spatial architecture and identify tumor microenvironment features.