L. Huang

This study shows E. coli can use DNA as a nitrogen source for growth, outperforming Bifidobacterium bifidum, and ingests long DNA directly without altering its length.

The paper analyzes chromatin landscapes of Th17 cell subsets to uncover regulatory mechanisms driving their heterogeneity and identifies BACH2 as a novel regulator of pathogenicity.

This paper introduces a method for real-time single-molecule protein sequencing using a semiconductor device, capable of detecting peptides and post-translational modifications with high sensitivity.

This paper assesses swimming fatigue in large yellow croakers by analyzing metabolites and constructs an endurance swimming model to inform aquaculture site selection.

The paper identifies and validates genes involved in metabolite damage repair and preemption in the minimized Mycoplasma JCVI-Syn3A genome and extends its metabolic map.

This study shows that Ser68 phosphorylation is essential for CENP-A deposition, centromere function, and mouse viability.

This study shows NtrX regulates CtrA signaling network genes in S. meliloti, affecting cell division and linking nitrogen metabolism to cell cycle control.

This paper uses AI-enabled multiscale computational microscopy to study SARS-CoV-2 Delta variant in respiratory aerosols, revealing atomic-level insights into airborne transmission.

This paper develops a selectable marker-free gene targeting system in soybean using Ochrobactrum haywardense-mediated delivery, achieving 3.4% targeted insertion and 90% mutation rate in T0 plants.

This study develops an AI-driven multi-resolution simulation workflow to study SARS-CoV-2 RTC dynamics, combining cryo-EM with mesoscale simulations and AI methods.

This study examines how Salmonella develops resistance to enrofloxacin under varying sub-inhibitory concentrations, identifying gene expression changes and mutations involved in resistance.

This study shows UCH37 deubiquitinates branched ubiquitin chains, enhancing proteasome clearance of stress-induced inclusions.

This paper identifies a small molecule agonist of Mtb adenylyl cyclase Rv1625c that inhibits cholesterol utilization and disrupts Mtb pathogenesis in mice.

The paper introduces a database that compiles antibody responses and clinical data from COVID-19 patients for analysis and visualization.

This study shows that ACVR1 antibodies, intended to block ACVR1 activation, instead stimulate heterotopic ossification in FOP by activating FOP-mutant ACVR1 through dimerization.

This study identifies plakoglobin and HMGB1 as key mediators of TcdB-induced intestinal epithelial cell apoptosis through mitochondrial pathways.

This study shows that loss of GdpP function in Staphylococcus aureus increases β-lactam tolerance and facilitates the evolution of β-lactam resistance.

This study establishes three clinical breakpoint values for danofloxacin against Glaesserella parasuis using epidemiological, pharmacodynamic, and clinical data.

This study identifies Rnd3 as a protective factor in placental mitochondria through PPARγ-UCP2 signaling, showing its role in mitigating oxidative stress in preeclampsia.

The paper develops a confocal microscopy method to quantify cytosolic siRNA delivery at the single-cell level and identifies dose-response relationships for knockdown efficiency.

This study estimates the de novo mutation rate in pigs using whole-genome sequencing of a three-generation pedigree and revises the evolutionary timeline of pigs, including divergence events and domestication history.

This study identifies age and ethnicity-specific gene expression biomarkers for immune aging using transcriptomic data from peripheral blood mononuclear cells.

This study shows that delayed type I and III interferon responses in nasal epithelial cells allow SARS-CoV-2 replication, but pre-infection IFN treatment restricts virus and preserves barrier integrity.

This study shows that the cationic peptide L-K6 enhances doxorubicin's effectiveness in drug-resistant cancer cells by inhibiting P-glycoprotein function and expression.

This paper identifies rtcisE2F as a circRNA that regulates liver TIC self-renewal and metastasis by modulating E2F6 and E2F3 mRNA stability through m6A reader interactions.

This study uses lattice lightsheet microscopy to show that PI3K activity is critical for sealing ruffles into macropinosomes, but not for regulating their morphology.

This paper introduces a bioprinting method that controls cellular orientation through stretching, enabling aligned myofiber formation and effective tissue repair in vivo.

This study identifies how Listeria monocytogenes uses InlB to protect infected monocytes from CD8+ T-cell mediated death, facilitating neuroinvasion and persistence.

This paper develops an AI-driven workflow to simulate SARS-CoV-2 spike protein dynamics, revealing glycan shield structure, spike glycans' role in infectivity, and spike-ACE2 interactions.