L. Huang

This study shows Arabidopsis myosin XIK interacts with the exocyst complex to facilitate vesicle tethering during exocytosis, revealing a role in secretory processes in plants.

This study shows PRMT5 promotes cancer metastasis by enhancing EGFR transcription and modulating AKT1 activation through methylation, leading to EMT and tumor cell invasion.

This study shows that PCK1 deficiency increases O-GlcNAcylation and promotes HCC growth under glucose deprivation by enhancing CHK2 activity.

This study analyzes immune responses in COVID-19 patients using single-cell RNA sequencing to identify differences in immune cell behavior across disease severity stages.

This study compares CRISPR/Cpf1 orthologs for genome editing efficiency and antiviral ability in silkworms, finding FnCpf1 more effective than SpCas9 against BmNPV.

This paper develops a nanoparticle-mediated method to enable in vivo analysis of RAS protein activity by delivering a fluorescent GTP analog into cells.

This study identifies an OsNCED2 allele that enhances aerobic adaptation in upland rice by improving root development and drought tolerance through increased ABA synthesis.

This paper develops a rapid, low-cost method to detect and quantify SARS-CoV-2 virus particles using nanoplasmonic sensors in microplate readers and smartphone devices.

This paper develops an in vivo protein kinase analysis method using chemical genetics and nanoparticle-mediated ATP analog delivery, demonstrating its applicability to AKT1.

This study investigates how neoantigen heterogeneity affects bystander immune inhibition in pancreatic cancer, finding that high neoantigen frequency is needed for effective antitumor response, which can be improved with immune therapy.

The paper introduces a method to improve pathogen detection in metagenomic data by correcting abundance estimates using species-specific genomic regions, enhancing sensitivity and specificity for low-abundance pathogens.

This meta-analysis compares first-generation EGFR-TKI plus chemotherapy to EGFR-TKI alone in advanced EGFR-mutated NSCLC, finding improved ORR, PFS, and OS with the combination, but increased toxicity.

Endosidin20 inhibits plant growth and synergizes with other cellulose synthesis inhibitors, showing potential as a spray herbicide.

Endosidin20 inhibits cellulose synthesis by targeting the catalytic site of CESA6, reducing cellulose synthase complex delivery to the plasma membrane.

This paper introduces VasNet, an unsupervised learning algorithm that improves vascular disease diagnosis from unlabeled images by focusing on retinal vasculature features.

This study shows anacardic acid reduces PE-induced cardiac hypertrophy by inhibiting JNK signaling and HAT-mediated histone acetylation in mice.

This study shows that Bacillus subtilis spore enhances mucosal immunity by promoting intestinal-resident memory T cells through ICAM-1 expression on dendritic cells.

The paper assesses changes in drifting fish egg composition and abundance in the Xijiang River after dam construction, linking these changes to environmental factors.

This study identifies acetylation as essential for NLRP3 inflammasome activation, showing that KAT5-mediated acetylation promotes NLRP3 aggregation and inflammasome assembly.

This study shows eIF3 interacts with 80S ribosomes to enhance early translation elongation of mRNAs involved in mitochondrial and membrane functions, critical for muscle health.

The paper systematically analyzes correlations between 221 physical examination indicators in healthy and disease states, identifies disease markers, and develops machine learning models to predict health status with high precision.

This study identifies two benzophenanthridine alkaloids from Corydalis longicalcarata rhizomes with anti-mitotic and polyploidy-inducing activities through a phenotypic screen of medicinal plant extracts.

This study identifies scavenger receptor B1 as the receptor for Mycobacterium tuberculosis on airway microfold cells, showing its role in bacterial transcytosis.

GLAnCE is a hydrogel platform that enables real-time observation of CAF-tumour cell interactions at the tumour-stroma interface, revealing interface-specific invasion and EMT gene induction.

The paper uses p19 to capture RNase III-cleaved dsRNA in E. coli, revealing widespread antisense transcription and its potential role in stress responses.

The paper determines the structural organization of a Type III-A CRISPR effector subcomplex using X-ray crystallography and cryo-EM, revealing details on crRNA binding and complex assembly.

This study shows that in Trypanosoma brucei, mitochondrial mRNAs and rRNAs are transcribed as individual precursors with defined 5' and 3' ends, processed by specific enzymatic activities and antisense RNA regulation.