L. Jiang

This study shows focused ultrasound activates ER-localized PANX1 in invasive cancer cells, triggering calcium release and cytokine release, suggesting a new adjuvant therapy for cancer immunotherapy.

This study shows that microbial adaptation reduces soil carbon loss under long-term warming by decreasing temperature sensitivity of respiration.

The paper develops an in vitro vesicle formation assay to identify proteins involved in cargo sorting and trafficking, revealing novel regulators like FAM84B and PRRC1.

The paper analyzes the evolution and variation of 2019-nCoV by comparing genomic sequences from multiple isolates, identifying amino acid variations and estimating the molecular clock and most recent common ancestor.

This study identifies and validates a core regulatory circuitry trio in Ewing sarcoma, showing how EWS-FLI1 and CRC factors regulate transcription and epigenome, with implications for therapy.

This study identifies calpain-2 as a regulator of hypoxia-induced amoeboid reprogramming and metastasis in breast and head and neck cancers.

This study determines the cryoEM structure of α-synuclein fibrils with the E46K mutation, revealing a more stable and pathogenic fibril structure compared to wild-type.

The paper identifies 179 prognostic lncRNAs across 29 cancer types using machine learning, showing their association with patient risk and tumor subtypes.

This study identifies NMNAT as a chaperone that prevents phosphorylated Tau aggregation in vitro and reduces pathology in a fly model.

This study evaluates how different nitrogen fertilizer rates affect tuber yield and processing quality of two potato cultivars, finding optimal rates for high yield and quality.

This study determines cryo-EM structures of alpha-synuclein fibrils with the H50Q mutation, revealing two new polymorphs and structural changes linked to disease mechanisms.

This study isolates and identifies actinomycetes from soil samples in southwestern China, revealing high diversity and antimicrobial potential.

This study shows that ablating tanycytes in male mice increases visceral fat and reduces insulin sensitivity, but not body weight or food intake.

This study identifies cAMP as an activator of GacB and cGAMP-specific phosphodiesterase PmxA, revealing cross-regulation between CDN pathways and predicting non-canonical HD-GYP enzymes.

This study shows that Protoporphyrin IX inhibits p53/MDM2 and p53/MDM4 interactions, stabilizes p53 and TAp73, and induces apoptosis in B-cell chronic lymphocytic leukaemia cells without harming normal cells.

The paper identifies HCSs associated with AT-less type I PKSs through genome mining and reveals their diversity across strains and soil samples.

This study identifies Cyclin B3's specific role in facilitating metaphase-to-anaphase transition in mouse oocyte meiosis I, while showing it is not required for oocyte maturation or sister chromosome segregation.

This study compares ruminal microbiota composition between high-yield and low-yield dairy cows using 16S rRNA gene sequencing, finding differences in bacterial abundance and community structure associated with milk production traits.

This study shows PIP5K1β regulates bone homeostasis by modulating osteoclast and osteoblast differentiation through multiple signaling pathways.

The paper uses citizen-science data to analyze human stool microbiomes, revealing new insights into microbial diversity, metabolome composition, and associations with diet and health.

The paper studies collective U-turns in fish schools, showing that speed decreases trigger these events, which propagate like dominoes and are modeled using an Ising spin model.

This study identifies liver-derived acyl-carnitines as a fuel source for brown fat thermogenesis, showing that cold exposure increases plasma acylcarnitine levels through hepatic HNF4 activation and that carnitine supplementation improves thermogenic response in aged mice.

The paper sequenced 1,504 mutant lines in the rice variety Kitaake and established a database to enable rapid functional genomic studies.