L. Jiang

This study determines the cryo-EM structure of VAR2CSA and its complex with CSA, revealing conformational changes and identifying mutations that abolish CSA binding and cytoadherence to placental and tumor cells.

This study identifies Lin28a's role in rejuvenating muscle stem cells through mitochondrial optimization and epigenetic regulation, enhancing their regenerative capacity.

This study shows that extracellular fluid flow reduces cellular quiescence depth through physical and biochemical cues, making cells more likely to reenter the cell cycle.

The paper identifies CDC20 missense variants linked to familial cancer, showing they impair SAC binding and promote mitotic slippage.

The paper develops a high-throughput method to measure protein interaction affinity without purification, applied to SUMO E2/E3 enzymes and substrates, revealing co-recognition and affinity mechanisms.

This study investigates the pharmacokinetics and biodistribution of extracellular vesicles in macaques via intravenous and intranasal routes, finding longer plasma circulation times and organ uptake with IV administration, but limited systemic distribution with IN.

The paper identifies TAZ as a molecular switch driving phenotypic transition and metastasis in SCLC by analyzing mouse models and human data.

This paper introduces SNU-seq, a method for single-nucleotide uracil mapping in DNA, validated on synthetic DNA and mammalian genomes, revealing uracil dynamics in treated cells and AID hotspots.

The paper identifies MK-derived immune-stimulating cells (MDICs) that enhance host defense against bacterial infections by interacting with myeloid cells and producing cytokines.

This study identifies new CCHFV strains in Inner Mongolia, China, showing genetic similarities to strains from Xinjiang and South Africa, suggesting long-term prevalence in the region.

This study identifies m5C mRNA modifications mediated by Plasmodium NSUN2 as critical for transcript stability and gametocyte development in malaria parasites.

This paper refines muscle-invasive bladder cancer classification using multi-omics data, identifying four subtypes with distinct prognoses and therapeutic responses.

This study verifies two SARS-CoV-2-encoded small RNAs and shows their role in promoting lung inflammation via cytokine and interferon pathways during infection.

This study identifies ID1 upregulation in DIPG tumor cells and shows that CBD can reduce ID1-driven invasiveness in vitro and in vivo.

The paper shows that CRISPR enriches cells with p53-related mutations and demonstrates that transient p53 inhibition can suppress this effect.

This paper introduces a CRISPR-based assay to identify drug targets affecting hematopoietic cells by analyzing genotype enrichment in mixed CRISPR populations.

This paper develops a chemiluminescence immunoassay for detecting ASFV antibodies in serum, showing high specificity, sensitivity, and consistency with a commercial kit.

The paper develops three RORγt inhibitors that reduce Th17 differentiation and inflammation in vivo and inhibit tumor growth in PDAC organoids.

This study shows that MMP12 knockout prevents weight and muscle loss in ApcMin/+ mice with cancer cachexia by disrupting insulin and glycolipid metabolism.

The paper maps root-microbe interactions in Arabidopsis thaliana by identifying host genetic variants and microbial hubs that influence microbial network structures and functions.

This paper optimizes a baculovirus system to efficiently produce all rAAV serotypes 1-13, achieving high yields and scalability for research and therapeutic applications.

This study investigates how the herbal medicine Kursi Wufarikun Ziyabit inhibits mitochondrial ATP production, activates AMPK, and induces FGF21 expression in hepatocytes, suggesting a mechanism for its therapeutic effect in type 2 diabetes.

This study shows that overexpressing purple acid phosphatase 2 in chloroplasts and mitochondria improves ATP production, plant growth, and seed yield by balancing reducing equivalents and enhancing photosynthesis.

The paper identifies C53 as a conserved ER-phagy receptor that links autophagy with ribosome-associated quality control during ER stress in plants and mammals.

This study shows berberine reverses multidrug resistance in Candida albicans by hijacking the Mdr1p efflux pump for drug import, leading to mitochondrial dysfunction and selective cell death.

This study shows that S100A9 promotes neural stem cell differentiation and inhibits their stemness, suggesting a role in neurodegenerative disease progression.

This study uses cryoEM to determine how EGCG binds to AD tau fibrils and initiates their disaggregation by wedging into a cleft and causing charge repulsions.

The paper shows pericentrin proteins condense into dynamic granules during mitosis, facilitating centrosome maturation through phase separation.

This paper reports the cryo-EM structure of the C9ORF72-SMCR8-WDR41 complex, revealing its role as a GAP for Rab8a and Rab11a.