L. Liu

This study introduces scStereo-seq, a method for single-cell spatial transcriptome profiling in Arabidopsis leaves, revealing cell type-specific spatial gene expression gradients and developmental trajectories.

The paper introduces a method to sense enzyme product formation using host cell metabolism and mass spectrometry to map enzyme activity and mutagenesis effects.

This paper identifies a monoclonal antibody, 2-36, that neutralizes SARS-CoV-2 variants, SARS-CoV, and other sarbecoviruses, with a conserved epitope in the RBD identified through cryo-EM.

This study shows that dimeric IgA antibodies can enhance SARS-CoV-2 nasal infection and injury in Syrian hamsters by engaging CD209 as an alternative receptor.

The paper identifies 2-isobutylmalate synthase (IBMS) as a novel enzyme related to IPMS that catalyzes the synthesis of 4-methylvaleric acid, a precursor of pogostone.

This study investigates how Schistosoma mansoni eggs interact biomechanically with vascular endothelial cells to facilitate their extravasation from blood vessels.

This study evaluates a vaccinia-based COVID-19 vaccine, showing it induces strong and long-lasting cellular and humoral immune responses in mice against SARS-CoV-2 variants.

This paper demonstrates that intranasal nanobody Nb22 provides short-term instantaneous prophylaxis and effective treatment against SARS-CoV-2 in hACE2 mice, with ultrahigh potency and long-lasting retention in the respiratory system.

This study uses genome-wide analysis to track polyploid emergence in Phragmites australis, identifying multiple lineages and ploidy levels with genomic conflicts.

This study shows that homoharringtonine (HHT) effectively inhibits KIT-dependent GIST growth by reducing protein synthesis, even in imatinib-resistant models.

The paper constructs a global microbiome transition network showing microbiomes are closely connected despite habitat differences, with a scale-free structure and a roadmap of dispersal.

This study identifies OPAQUE1 as essential for phragmoplast guidance during asymmetric cell division in maize, showing it interacts with kinesins to ensure proper cytokinesis.

This study develops a single-dose rAAV5-based vaccine that provides long-term immunity against SARS-CoV-2 and its variants with high neutralizing antibody titers and safety.

This study investigates the cellular localization and cytoskeleton interactions of reflectin proteins, revealing their localization preferences and potential mechanisms for nuclear entry and cytoskeletal binding.

The paper synthesizes and tests aryl aminothiazole γ-secretase modulators, finding that structural changes alter Aβ peptide production profiles and stimulate carboxypeptidase trimming.

This study regenerates functional B lymphopoiesis from pluripotent stem cells (PSCs) using Runx1, Hoxa9, and Lhx2, producing antigen-specific antibodies and immune memory in B-cell deficient animals.

This study uses TMT-based proteomics to analyze the antibacterial effects of YACTH against Staphylococcus aureus, identifying 490 differentially expressed proteins and their biological pathways.

This paper introduces two computational methods for accurately positioning functional residues in proteins and validates them by redesigning enzyme active sites.

This paper reports the cryo-EM structure of antibody 5-7, which binds to a distinct site in the SARS-CoV-2 spike NTD, showing neutralization resistance to variants of concern.

This study identifies DAB2IP as a tumor suppressor in colon cancer that inhibits p53 degradation by competing with GRP75 for binding, thereby enhancing p53 stability and suppressing tumor growth.

The paper develops a fluorescent polarization assay to screen SARS-CoV-2 fusion inhibitors, showing effective inhibitors with sub-mM concentrations and validating the assay with a high Z factor.

The paper introduces a method to degrade specific proteins and organelles using engineered autophagy receptors, demonstrating its effectiveness in plant and transient expression systems.

This study shows HO-2 binds and buffers oxidized labile heme in HEK293 cells, regulating heme homeostasis by controlling bioavailability rather than degrading heme under non-stress conditions.

This study shows that Sel1L regulates T cell survival, homeostasis, and immune responses by controlling ERAD, mTOR activation, and metabolic processes.

This study determines the structure of post-fusion hMPV B2 F protein, assesses its receptor binding and immunogenicity, and shows it induces neutralizing antibodies against multiple hMPV strains.

This study shows a single-dose AAV-based vaccine induces long-lasting neutralizing antibodies against multiple SARS-CoV-2 variants in rhesus macaques.

This study shows that soluble CD138 enhances APRIL-mediated B cell survival and autoreactive antibody production in MRL/Lpr mice, contributing to SLE pathology.

This study shows matriglycan can independently bind Laminin, viral proteins, and antibodies, and block viral infection, suggesting it acts as a tunable receptor.

The paper identifies glucose and amino acid contributions to hepatic de novo lipogenesis and steatosis in obesity using metabolic tracing and in vivo studies.