L. Liu

RNA-CLAMP enables photo-activated control of CRISPR-Cas9 gene editing by clamping and photo-cleaving sgRNA stem loops to regulate activity.

The paper introduces a method to construct customizable QconCATs for proteomic quantification using synthetic biology principles.

This study reports cryo-EM structures of Ubr1 complexes to elucidate the mechanism of ubiquitination initiation and elongation using a single E2 enzyme.

This study investigates how Pseudomonas aeruginosa adapts and evolves during coinfection with COVID-19, showing it overexpresses alginate and reduces Type VI secretion system to enhance biofilm formation and suppress virulence.

This study analyzes SARS-CoV-2 substitutions and codon usage in humans and animals, finding higher substitution rates and adaptation in mink compared to other species.

This study identifies 12 serum metabolites associated with esophageal squamous cell carcinoma and highlights pipecolic acid as a predictive biomarker for tumorigenesis.

This study identifies NPR1 and EDS1 as interacting coactivators that synergistically activate PR genes and plant defenses through Mediator complex recruitment and mutual stabilization.

This study shows that influenza A and D viruses interfere with each other during coinfection based on the timing and order of infection, with proinflammatory responses playing a key role.

The paper shows Hülle cells in Aspergillus nidulans produce xanthones that protect reproductive structures from fungivorous animals.

This study shows that MFG-E8 promotes Ang II-induced arterial inflammation and remodeling in aging, and its deficiency reduces these effects.

This study identifies BIRG1 as a chloride efflux transporter in rice that regulates grain size and salt tolerance by controlling chloride homeostasis.

This study shows YAP1 promotes breast cancer metastasis by enhancing TIAM1 expression through its enhancer, leading to increased RAC1 activity and invadopodia formation.

This study shows the SARS-CoV-2 P.1 variant is more resistant to antibody neutralization than previous variants, but less affected by vaccine-induced immunity.

This study reports cryo-EM structures of two SARS-CoV-2 neutralizing antibodies bound to spike proteins of emerging variants, showing they retain potency despite RBD mutations.

The paper assesses amino acid and amine stability in human serum under various preprocessing and storage conditions using iTRAQ(R)-LC-MS/MS.

This study identifies tankyrase-mediated ADP-ribosylation as a regulator of TNF-induced cell death by promoting complex 2 assembly and interacting with RNF146.

This study presents cryo-EM structures of human p97 complex with and without inhibitor NMS-873, revealing conformational changes and allosteric inhibition mechanisms.

The paper identifies a bZIP transcription factor, SWIZ, involved in grass thigmomorphogenesis, showing its nuclear translocation after mechanostimulation and its role in regulating gene expression.

This study shows prior SARS-CoV-2 infection in golden hamsters provides partial protection but not sterilizing immunity, and virus can still be transmitted between infected and naive animals through direct contact.

This study evaluates the neutralization resistance of SARS-CoV-2 variants B.1.1.7 and B.1.351 to monoclonal antibodies and sera, finding increased resistance in B.1.351.

This study identifies SlBES1 as a regulator of tomato fruit softening by repressing PMEU1, leading to firmer fruits with extended shelf life without affecting visual or nutritional quality.

This study identifies mitotic R-loops as regulators of centromeric cohesion through their interaction with Aurora B kinase and the Chromosome Passenger Complex.

The paper determines structures of three VH1-2-derived antibodies in complex with SARS-CoV-2 spike, revealing modular recognition mechanisms and conformational changes.

The study identifies a 416-bp deletion in the AFF gene's promoter that reduces its expression, leading to all-flesh tomato fruits and providing insights into berry fruit evolution.

This study identifies a public antibody class, IGHV3-53/3-66, with potent SARS-CoV-2 neutralization capabilities through paired heavy and light chain interactions.

This paper develops an ultrasensitive biosensor to quantify SARS-CoV-2 RBD and ACE2 interactions in cells and in vitro, enabling rapid evaluation of viral mutants and drug candidates.

The paper examines HDP gene expression and tissue distribution in different chicken breeds, finding correlations between body weight, age, and HDP expression in immune organs and intestine.

This paper introduces light-activated tetrazines to enable precise spatiotemporal control of bioorthogonal reactions in live cells.

This study identifies and characterizes MAIT cells in cattle, showing their functional response to bacterial infections and their enrichment in mucosal tissues.