L. Zhang

This study investigates host shifts in Nearctic oak gall wasps and finds frequent shifts between host plants and organs, suggesting host shifts drive speciation in this group.

This study shows that chronic intermittent hypobaric hypoxia prevents contrast-induced acute kidney injury in rats by activating the HIF-1/BNIP3 pathway to enhance antioxidant capacity and mitochondrial autophagy.

This paper identifies a SARS-CoV-2 neutralizing antibody, ABP-310, that is effective against multiple variants including Omicron and SARS-CoV, suggesting broad therapeutic potential.

This study compares Reelin+ HSCs and Desmin+ HSCs in liver fibrosis using fate tracing, showing differences in activation, migration, and proliferation in response to cholestatic and hepatotoxic injuries.

CoVac501, a self-adjuvanting peptide vaccine with TLR7 agonists, induces strong neutralizing antibodies and T cell responses in non-human primates against SARS-CoV-2.

This study uses single-nuclei transcriptomics to analyze dog hippocampus cell types and identifies convergence between differentially expressed genes and putative positively selected genes related to nervous system development.

This study compares the transcriptional responses of two nematodes to different diets, finding diet-specific effects on development and lifespan.

The paper identifies a DNA uptake mechanism in cell wall-deficient bacteria that resembles eukaryotic endocytosis and may represent an ancient process for macromolecule acquisition.

The paper identifies type IV pili as a critical virulence factor in Paenibacillus thiaminolyticus clinical isolates associated with postinfectious hydrocephalus.

This paper evaluates click chemistry-based methods for cross-linking peptide enrichment, finding that acid-cleavable protein-based conjugation identifies the most cross-linked peptides.

This paper introduces SPACX, a method to profile protein conformation and interactions in living cells, revealing subcellular-specific heterogeneity and functional differences in PTEN.

This study uses imaging mass cytometry to analyze tumor-immune microenvironments in melanoma patients, identifying distinct microenvironment archetypes linked to responses to anti-PD-1 therapy.

The paper analyzes the distribution of virulence factors in Bacillus cereus strains using phylogenetic and protein prediction methods, revealing clustering based on virulence genes and structural features.

This study identifies KLK10 as a flow-sensitive endothelial protein that inhibits inflammation and atherosclerosis through a PAR1/2-dependent mechanism involving HTRA1 regulation.

This study identifies FAM84B amplification as a marker of poor prognosis in ESCC and shows it promotes cell proliferation by interacting with NPM1 to suppress CDKN2A.

This study reports the crystal structure of the Omicron SARS-CoV-2 RBD-ACE2 complex and identifies key mutations enhancing ACE2 binding and immune escape.

The paper examines how ecology and geography influence habitat and sexual isolation in closely related gall-forming wasp species, finding that sympatric species with different host plants show the strongest isolation.

The paper tracks cyanopeptides and their impact on microbiota during a CyanoHAB, finding that cyanopeptide restriction and degradation drive community assembly.

This study identifies THEMIS as a substrate of SHP1 and shows it has phosphorylation-dependent and -independent roles in T cell development.

This study shows an engineered ACE2 peptide effectively mitigates ARDS and death in mice infected with multiple SARS-CoV-2 variants.

This study identifies potent inhibitors targeting KRAS G12D via a salt-bridge interaction, showing efficacy in reducing tumor volume and synergizing with anti-PD-1 therapy.

This study profiles healthy human kidney cells from 19 donors to reveal sex-based transcriptional differences and tissue-specific immune features.

This study shows that a specific static magnetic field reduces oxidative stress and liver damage caused by alcohol consumption in mice.

This study shows that IGF-1C and P24 together enhance osteogenic differentiation of BMSCs by activating p38 and JNK pathways.

The paper identifies LRRC15 as an inhibitory receptor that blocks SARS-CoV-2 spike-mediated entry in trans, primarily expressed in fibroblasts and not co-expressed with ACE2.

This study identifies circRNA expression patterns in healing and non-healing wounds and finds two circRNAs that impair keratinocyte migration while promoting proliferation in non-healing venous ulcers.

This study identifies genes involved in salinity adaptation in the marine nematode Litoditis marina through transcriptomic and proteomic analysis of worms acclimated to different salinities.

This study shows NtrX regulates CtrA signaling network genes in S. meliloti, affecting cell division and linking nitrogen metabolism to cell cycle control.

This study develops an intranasal vaccine against SARS-CoV-2 using an influenza virus vector and shows it provides rapid, prolonged, and broad protection against multiple variants in hamsters.

The paper presents cryo-EM structures of yeast TRAPPII complex in apo and Ypt32-bound states, revealing its assembly mechanism and specific activation of Ypt31/Ypt32.