M. Chen

This paper introduces PS-ApTCs, a novel PROTAC design using aptamers for spatioselective degradation of nucleocytoplasmic shuttling proteins, showing enhanced efficacy and synergistic effects in cancer therapy.

This study shows intermittent hypoxia therapy doubles C. elegans lifespan without HIF-1 but requires DAF-16/FOXO and other phosphatidylinositol signaling components.

This study identifies how avian-origin H3N2 influenza viruses adapt to dogs, acquiring traits that increase their potential to infect humans.

This study shows that hematopoietic stem cells (HSCs) do not contribute to mature blood cell regeneration during common emergencies like inflammation or blood loss.

The paper introduces a chemoenzymatic method to detect cell-surface glycan in single-cell multiomics, showing increased LacNAc in activated CD8+ T cells and its correlation with glycolytic activity.

This study shows that fibronectin-integrin α5 signaling drives thoracic aortic aneurysms in Marfan syndrome mice, with a 5/2 chimera mutation reducing aneurysm severity.

This study shows that the p73{gamma}-Leptin pathway promotes tumorigenesis and alters lipid metabolism by demonstrating that E11 deletion increases p73{gamma} and Leptin, leading to oncogenic effects in mice and human cancers.

This paper develops multispecific antibodies that neutralize all SARS-CoV-2 variants, including Omicron, by targeting multiple epitopes on the spike protein.

The paper compares N-glycoproteomes of HCT116 cancer cells and DKO1 non-tumorigenic cells, revealing hyper-M6P modification and its potential role in cancer biology.

The paper uses a cross-scale model to predict how photosynthetic manipulations affect wheat and sorghum yield across environments, finding modest gains with some strategies and challenges in scaling up.

This study identifies epsin-2 as a therapeutic target for multiple system atrophy by regulating FABP7/-synuclein hetero-aggregates propagation.

This study identifies differentially expressed genes and pathways in Kluyveromyces marxianus under acetic acid stress during high-temperature ethanol fermentation, revealing effects on protein metabolism and ethanol production.

This study compares the microstructural organization and biomechanical properties of osteochondral units in marine and terrestrial mammals, finding significant differences in collagen fiber arrangement and cartilage stiffness.

The paper determines 3D structures of IP3R1 in two ligand-bound states using cryo-EM and identifies dynamic properties of key domains involved in ligand binding and channel gating.

The paper introduces NAD+ sensors to measure subcellular and clinical NAD+ dynamics, revealing NAD+ redistribution effects of -GPC in live cells.

This study maps epithelial cell states and plasticity in lung adenocarcinoma using single-cell data, identifying KRT8+ alveolar intermediate cells linked to poor survival and tumorigenesis.

This study shows metformin reduces Cyp26a1 expression, increasing atRA levels and decreasing pro-tumor CD8+ T cells, thereby preventing hepatocarcinogenesis in a mouse model.

The paper identifies six monoclonal antibodies that broadly neutralize coronaviruses by targeting the conserved fusion peptide.

This study determines the structure of the chikungunya virus replication complex at near-atomic and subnanometer resolution, revealing its molecular architecture and implications for antiviral therapy.

This study shows that genomic GC content variation in bacteria is influenced by ancient adaptation legacies, particularly through DNA replication and repair systems, rather than neutral processes.

The paper examines antibody responses to SARS-CoV-2 variants, finding convergent epitope specificities, V gene usage, and public B cell clones across different variants.

The paper describes a collection of 79 genomically and clinically annotated lung cancer PDX models that retain patient tumor features and treatment responses, available through MMHCdb.

This study integrates deep learning with reflectance confocal microscopy to enhance Raman spectroscopy's specificity in diagnosing basal cell carcinoma.

This study investigates how selective endocytosis regulates slit diaphragm dynamics in Drosophila nephrocytes, revealing roles for dynamin and flotillin in maintaining filtration barrier function.

The paper identifies hpm91, a Chlamydomonas mutant with high hydrogen production, as scalable and robust for large-scale algal H2 photoproduction.

The paper develops AI-powered IoT sensors for tracking mouse behaviors with 76.23% accuracy, addressing imbalanced data through sampling and feature selection techniques.

AtGPA1 regulates low-nitrogen stress response in Arabidopsis by interacting with AtNRT1.4 and AtATG8a, affecting nitrate uptake and autophagy.

This paper identifies an antibody, WS6, from a mouse immunized with SARS-CoV-2 spike mRNA, which neutralizes diverse beta-coronaviruses by targeting a conserved helical epitope on the S2 subunit.

The paper identifies and deletes 19 Myb genes in Magnaporthe oryzae, finds most are expressed during infection, and identifies co-regulated groups with potential roles in pathogenicity.