S. Huang

The paper identifies a distinct population of red cells in lung tissues, called Red Soma Cells (RSC), which contribute to lung redness and have unique biological functions.

This study finds that synovial levels of IL-8, MIP-1α, and VEGFA correlate with lubricin glycan truncation in OA, suggesting a link between glycan changes and local inflammation.

This paper presents a hardware-software solution for co-registering photoacoustic tomography and MRI images in vivo, demonstrating hybrid-contrast imaging of tumor microenvironments.

This study identifies and characterizes six AcMNPV-encoded miRNAs, showing they regulate both viral and host genes through suppression or enhancement of target expression.

The paper identifies flavinylation's role in diverse extracytosolic redox functions across bacteria through genomic analysis and gene cluster mining.

This study identifies FDA-approved drugs that inhibit urease activity in H. pylori, offering potential new treatments for infections.

The paper introduces IRCA to infer metabolite conversion networks from single-cell Raman spectra of isogenic populations without time-series data.

This study uses MSOT to non-invasively visualize lipid accumulation in mice with NAFLD, showing its potential for monitoring hepatic steatosis without contrast agents.

This study uses sedimentary ancient DNA to analyze plant diversity changes over 28,000 years in Far East Russia, revealing different assembly rules in cold and warm climates.

This study shows natural transformation in Staphylococcus aureus facilitates SCCmec transfer, contributing to MRSA emergence.

This paper introduces 2bRAD-M, a low-cost metagenome-sequencing method that enables species-level microbial profiling of low-biomass and degraded samples with high accuracy.

This study compares host transcriptional responses to typhoidal and non-typhoidal Salmonella serovars in human intestinal organoids, revealing distinct gene expression patterns and immune responses.

This study uses immune simulation to show that HLA class I genotypes influence the effectiveness of multi-epitope vaccination strategies against SARS-CoV-2.

This paper develops deep-learning models to identify hypoxic tumor regions using MRI and histology, showing their effectiveness in predicting hypoxia and guiding TH-302 therapy response in sarcoma models.

This study uses human intestinal organoids to investigate how Salmonella SPI-1 and SPI-2 T3SSs influence host transcriptional responses during infection, revealing distinct and overlapping roles in inflammation and cell cycle suppression.

The paper identifies a suboptimal-health gum state (SoH) during experimental gingivitis, characterized by microbiome and metabolite changes similar to periodontitis.

The paper identifies JIB-04 as a broad-spectrum antiviral that inhibits SARS-CoV-2 replication and coronavirus pathogenesis in vitro and in vivo.

The paper identifies proximal tubule cell state and metabolism as coupled by nuclear receptors in kidney disease using single-cell RNA-sequencing.

The paper investigates the role of EphA3 in T cell acute lymphoblastic pre-leukemia stem cells, showing it enables the halt in differentiation of neighboring WT cells, allowing pre-leukemic cells to persist in the thymus.

This study shows that commensal bacteria modify heparan sulfate, reducing SARS-CoV-2 spike protein binding and that this bacterial presence decreases with age, increasing COVID-19 susceptibility.

This study shows that E. coli lacking RpoS has reduced colonization ability in human intestinal organoids but not in germ-free mice, indicating different stress environments in these models.

This study integrates multi-omic data from COVID-19 patients to identify immune response patterns linked to disease severity.

The paper analyzes synonymous sites in SARS-CoV-2 genes to assess translational efficiency trends and their implications for viral adaptation and epidemic growth.

The paper reports cryo-EM structures of GPBAR-Gs complexes, revealing structural features of bile acid recognition, allosteric effects, and biased signaling.

This study evaluates the virucidal activity and safety of Povidone-iodine in-situ gel formulations against SARS-CoV-2 in vitro and in vivo.

This study identifies PSGL-1 as an HIV restriction factor that inhibits HIV DNA synthesis and virion infectivity by restricting actin dynamics and sequestering HIV envelope proteins.

This study uses single-cell RNA-sequencing to identify a transitional cell state in peripheral neuroblastic tumors associated with poor prognosis and therapeutic targets.

This study quantifies the heterogeneous timing of asexual cycles in Plasmodium falciparum using time-lapse microscopy and finds that unsynchronized cultures have a bimodal burst time distribution and that artificial synchronization does not fundamentally alter cycle dynamics.

The paper develops non-toxic virucidal macromolecules effective against multiple influenza strains in vitro and in vivo.

This paper analyzes ancient Y chromosome data to support the Asia origin model for modern human paternal lineages over the African origin model.