S. Huang

The paper shows TIR domains catalyze ADP-ribosylation reactions to produce signaling molecules that specifically activate the EDS1-SAG101-NRG1 immunity branch in plants.

The paper identifies TIR-catalyzed pRib-AMP/ADP as a signaling molecule in plant immunity and shows it binds to the EDS1-PAD4 complex.

This study shows human neutrophils enhance intestinal epithelial cell extrusion to reduce Salmonella burden during infection, beyond direct antimicrobial activity.

The paper reanalyzes ancient whole-genome duplication events in leptosporangiate ferns using phylogenetic methods and substitution rate corrections, identifying four WGDs and highlighting methodological uncertainties.

COSMOS enables real-time, unlabeled cell sorting based on morphology using deep learning, achieving high enrichment of viable cells for functional analysis.

The paper shows that bacterial metatranscriptomes in wastewater can distinguish SARS-CoV-2 infected from uninfected human populations without directly detecting viral transcripts.

This study reports cryo-EM structures of NMUR1 and NMUR2 bound to NMU and NMS, revealing peptide selectivity mechanisms and activation principles for drug design.

The paper identifies neutralizing antibodies from early SARS-CoV-2 infections that retain activity against Omicron and other variants, highlighting the role of germinal center mutations in their broad neutralization.

The paper evaluates antiviral effects of 95 single compounds and 30 combinations, showing that molnupiravir with other drugs inhibits SARS-CoV-2 replication in human nasal epithelium in vitro.

This paper introduces an imaging-guided bioreactor for de-epithelialization and long-term cultivation of ex vivo rat trachea, enabling real-time monitoring and cell replacement for bioengineered tissue applications.

This study extracts and purifies β-2,7,11-cembratriene-4,6-diol from tobacco leaves and demonstrates its antiviral activity against TMV through in vivo and molecular assays.

This paper presents a model showing how cancer treatments can induce stemness, leading to tumor recurrence, and suggests optimizing dosing to avoid this.

This study evaluates human liver organoids for DILI risk prediction using high-throughput screening and a liver-on-chip system, showing enhanced predictive capacity and physiological relevance.

The paper solves the native structure of a human GBP coatomer that coats cytosolic bacteria and functions as an antimicrobial signaling platform.

This study shows that ether anesthetics suppress long-distance calcium and electrical signaling in Venus flytraps by targeting ion channels in the trigger hair, without affecting initial calcium signals.

This study isolates and characterizes two nanobodies against SARS-CoV-2 that neutralize the virus through distinct mechanisms, with one showing efficacy against the Alpha variant and reduced activity against the Beta variant.

This study identifies HOTTIP's role in regulating miR-196b expression through chromatin remodeling, which promotes leukemogenesis by altering FAS signaling.

This study identifies TMEM-120/TMEM120A as a conserved protein that promotes fat storage by enhancing triacylglycerol synthesis and lipid droplet expansion in C. elegans and mammalian cells.

This study shows ARID1A loss activates HERVH, which promotes tumor growth by modulating BRD4-dependent transcription in colorectal cancer.

This paper characterizes a glycolipid glycosyltransferase (GTcp) from Candidatus Pelagibacter sp. HTCC7211, showing its broad substrate specificity and role in glycoglycerolipid synthesis under phosphorus stress.

This paper demonstrates a genotype-independent in vivo haploid induction system in dicot crops by mutating DMP genes, achieving HI rates of 1.9%, 2.4%, and 1.2% in tomato, rapeseed, and tobacco respectively.

This paper develops a machine learning model using Raman spectroscopy to accurately identify viruses, achieving high accuracy in classifying virus types and subtypes.

The paper performs a multi-omics meta-analysis of microbial and metabolite data from diverse environments, revealing patterns of diversity and co-occurrence across biomes.

This study determines the cryo-EM structure of the 5-HT1F receptor complex with lasmiditan and a G protein, revealing the mechanism of selective activation and informing drug design.

The paper develops an in vitro model of the human esophagus to study ancestral differences in response to bile acid injury, finding significant differences between European American and African American-derived cells.

This study identifies heat-responsive genes in pea anthers and stipules using RNA sequencing and qPCR, revealing shared and variety-specific gene expression changes related to heat tolerance.