S. Liu

The paper identifies distinct genetic pathways in Shwachman-Diamond syndrome that lead to pre-leukemic and compensatory clonal hematopoiesis through EIF6 and TP53 mutations.

This study designs excretable AIE dots for deep-tissue imaging in marmosets, demonstrating their biocompatibility and excretion capabilities.

The paper identifies Lem27 as a bacterial deubiquitinase that regulates ubiquitin dynamics on Legionella phagosomes by counteracting E3 ligases.

This paper establishes a theoretical variance lower bound for fluorescence microscopy image denoising using Cramer-Rao Lower Bound and microscope system properties.

This study evaluates antibody responses to different SARS-CoV-2 spike protein antigens in rabbits, finding that the RBD antigen elicited higher affinity and titer neutralizing antibodies.

This study demonstrates that ADXS-NEO, a personalized Listeria monocytogenes vaccine, effectively targets tumor-specific mutations and controls tumor growth in mice by inducing neoantigen-specific T cell responses.

This paper demonstrates genetic engineering of liver organoids to enhance maturation and functionality through CRISPR and transcription factor overexpression.

This study shows ARID1A has opposite roles in promoting neural differentiation and suppressing cardiac differentiation from human pluripotent stem cells.

This paper shows PIWIL1 promotes gastric cancer independently of piRNA by interacting with the NMD pathway.

This study reconstructs the phylogeny and biogeography of Heliamphora, revealing evolutionary transitions and climatic impacts on its distribution.

This study evaluates 19 antiviral drugs against SARS-CoV-2 infection and finds remdesivir to be the most effective, while others show limited or no direct antiviral activity.

This study creates a single-cell transcriptome atlas of a non-human primate to explore SARS-CoV-2 targets and immune responses, identifying potential therapeutic targets and mechanisms linking IL6 to viral entry.

This study uses iPSC-derived cardiomyocytes from DCMA patients to show reversible mitochondrial fragmentation and OPA1 isoform imbalance, suggesting SS-31 as a potential therapy.

This study investigates how maternal hyperandrogenism and insulin resistance in pregnant rats affect ferroptosis in uterine and placental tissues, revealing differential molecular and cellular mechanisms.

This study identifies recurrent neoantigens in esophageal carcinoma using mutation data from multiple sources, highlighting potential targets for immunotherapy.

The paper analyzes CD45 isoforms in T cells from liver cancer patients to show their role in T cell heterogeneity and function.

This study investigates how TSG-6 affects BMP-4/Smad signaling and odonto/osteogenic differentiation of DPSCs in an inflammatory environment.

This paper identifies EK1C4, a potent fusion inhibitor against SARS-CoV-2 and other coronaviruses, showing high efficacy in vitro and in vivo.

This study identifies a non-hypermucoviscous ST11 hypervirulent K. pneumoniae strain lacking classical virulence factors, showing increased virulence through ampR and WcaJ mechanisms.

This study shows artesunate interacts with the vitamin D receptor to reverse sepsis-induced immunosuppression by enhancing autophagy and modulating NF-κB activity.

The paper quantifies species-specific CpG distribution patterns across genomic scales and shows their correlation with chromatin structure in mammals and avians.

This study shows that force on F-actin enhances E-catenin binding but not vinculin, revealing a modular mechanism for force-sensing by α-catenin.

This study uses functional principal component analysis to identify genetic loci regulating phenotypic change over time in sorghum, successfully detecting known genes not found in single-time-point analyses.

This study examines the relationship between ocular biometrical parameters and diabetic retinopathy in Chinese adults with type 2 diabetes, finding associations between axial length, lens power, and AL/CR ratio with DR risk.

This study examines the effects of rhein on bile acid homeostasis in rats, showing dose-dependent changes in bile acid levels and transporter expression without liver or kidney toxicity.

This study identifies new epigenetic and genetic biomarkers for esophageal cancer using cfDNA and combines SALP-seq with machine learning.

This paper introduces GNEPS, a fluorescent sensor that detects intracellular GTP:GDP ratios in real-time, showing its utility in monitoring metabolic changes across cell types and organelles.

The paper examines how 3D chromatin structure and DNA methylation change in cancer, showing increased segregation of chromatin domains and methylation differences that correlate with transcriptional changes.

This study uses ultra-deep sequencing to analyze clonal mutations in sun-exposed and non-sun-exposed skin, finding higher UV-signature mutations and mutation burden in sun-exposed samples.

This study identifies ZNF704 as a driver of breast carcinogenesis by disrupting circadian rhythms through repression of PER2 and other clock genes.