S. Yang

This study develops a sessile drop chip to create 3D spheroids of fibroblasts and macrophages, showing that M2 macrophages enhance fibroblast proliferation and differentiation in a wound-healing model.

This study identifies a regulatory axis involving acetylation and ubiquitination of Isw1 in Cryptococcus neoformans that controls multidrug resistance.

This paper develops a shortwave infrared sinuscope to detect cerebrospinal fluid leaks without contrast agents, showing that CSF has an absorption profile similar to water.

This study shows that PXN phase separation drives focal adhesion assembly and integrin signaling through light-inducible manipulation.

This paper discovers Vibrio natriegens as a microbial platform for efficient formic acid utilization and remodeled it to enhance formate consumption and indigoidine production.

The paper identifies 10 subsets of lung cancer-infiltrating Tregs, showing one subset is suppressive and linked to anti-PD-1 resistance while another is Th1-like and associated with PD-1 response.

This paper develops a machine learning workflow to predict antimicrobial susceptibility and MIC of Klebsiella pneumoniae to meropenem using single-cell morphological features within sub-doubling time.

This study identifies RSV-induced actin cytoskeleton expansion in ciliated cells as a novel mechanism contributing to bronchial wall thickening in adults.

The paper investigates microbial diversity and community dynamics in the Eger Rift subsurface, revealing a diverse archaeal population and evidence of anaerobic and acidophilic communities.

The paper identifies a fibroblast trajectory associated with cardiac fibrosis and shows that macrophage-fibroblast crosstalk via IL-1β signaling drives fibrosis.

The paper identifies a TGFb-induced immune response in melanoma using a zebrafish reporter and shows the need for chronic TGFb biomarkers.

The paper shows that convergent evolution of Omicron variants evades antibodies from BA.5 infections while maintaining ACE2 binding, driven by immune imprinting.

The paper shows that circulating phageome in cfDNA reflects bacterial infections and can distinguish between pathogenic and contaminant bacteria.

The paper identifies a potent and broad sarbecovirus-neutralizing antibody cocktail, SA55+SA58, from SARS convalescents to combat Omicron variants and other fast-evolving viruses.

This study characterizes the enhanced infectivity and antibody evasion properties of the SARS-CoV-2 Omicron subvariant BA.2.75 compared to BA.5 and other variants.

This paper develops a method to detect cancer noninvasively by integrating methylation, fragmentation, and copy number data from plasma cell-free DNA using machine learning.

This study uses single-cell RNA-seq to identify intercellular communication drivers of myocardial fibrosis in diabetic mice, highlighting key ligand-receptor interactions and fibroblast subpopulations involved in fibrosis.

This study shows membrane curvature regulates Piezo1 distribution in live cells, with Piezo1 depletion from curved protrusions and enrichment in invaginations, and activation reduces filopodia formation.

The paper examines methane cycling in Arctic thermokarst lagoons and finds that sulfate-driven anaerobic methane oxidation reduces sediment methane concentrations.

This study identifies multiple ParA/MinD ATPases in bacteria that coordinate the positioning of diverse cellular cargos, revealing specificity determinants and indirect regulatory interactions.

This study demonstrates that transfersomes (TLipo) can deliver drugs topically to the middle and inner ear without damaging the tympanic membrane, showing safety and efficacy in vitro and in vivo.

This study identifies a novel Arf1 binding site on WRC that drives activation through a mechanism distinct from Rac1.

The paper reports WAVE Regulatory Complex structures bound to Rac1, revealing how Rac1 binding at the A site activates WRC to drive actin polymerization.

The paper investigates HIV-1 spike protein dynamics using cryo-EM and simulations, showing how tilting exposes the MPER to antibody attack and alters membrane fusion.

This study investigates antibody evasion by SARS-CoV-2 Omicron sublineages BA.2.12.1, BA.4, and BA.5 against plasma from vaccination and BA.1 infection, showing increased neutralization escape.

The paper develops Mal-ID, a machine learning framework using immune receptor data to diagnose diseases, detecting infections, autoimmune disorders, and vaccine responses.

This study identifies the Toll pathway as a key antiviral defense in honey bees, with PGRP-S2 acting as a pattern recognition receptor that interacts with viral proteins to activate the pathway against IAPV infection.