X. Ma

This study identifies P4HA2-dependent prolyl hydroxylation of YAP1 as a suppressor of prostate cancer cell migration, invasion, and metastasis.

This paper investigates the role of apolipoprotein M in anthracycline cardiotoxicity, finding that ApoM protects against cardiac dysfunction and lysosomal injury through the autophagy-lysosome pathway.

The paper identifies genetic interactions in childhood cancers using a statistical pipeline, revealing 15 co-occurring and 27 mutually exclusive gene pairs, with most mechanisms linked to tumor subtypes or pathways.

This paper describes a protocol for inducing collagen-induced arthritis (CIA) in mice using bovine collagen type II and Freund's adjuvants, and reports associated enteritis and arthritis outcomes.

The paper develops a kinetic model to study sRNA-mediated gene regulation, revealing co-transcriptional regulation and identifying binding as a rate-limiting step.

This study shows HIF-2 regulates intestinal ferritinophagy via NCOA4, which is essential for systemic iron homeostasis.

The paper identifies ubiquitylated proteins in Arabidopsis during MAMP-triggered immunity, revealing the ubiquitin-proteasome system's role in immune regulation.

The paper reports an unexpectedly high mutation rate in Thermococcus eurythermalis, challenges the hypothesis of low mutation rates in hyperthermophiles, and links mutation rate to genome size and population dynamics.

St. Jude Cloud provides a genomic data sharing ecosystem for pediatric cancer research, offering access to over 10,000 patient genomes and enabling analysis of cancer subtypes and mutational signatures.

This study screens herbal extracts against stationary phase Bartonella henselae and identifies five with antimicrobial activity, including Cryptolepis sanguinolenta, Juglans nigra, and Polygonum cuspidatum.

This study shows that increased CD44 expression in human skin and endometrial stromal fibroblasts, compared to other mammals, correlates with higher cancer vulnerability.

This paper identifies a novel sodium signaling complex involving NALCN and SLO2.1 channels that regulates uterine smooth muscle cell membrane potential and contractility.

This study shows that PAK3 kinase activity regulates the switch from tangential to radial migration in cortical interneurons by affecting cell shape and polarity.

The paper screens SARS-CoV-2 target cells across 11 animal species using single-cell transcriptomes, finding higher proportions in cats and detecting them in multiple pig cell types.

The paper investigates mitochondrial lipid import in yeast, showing that di-unsaturated phosphatidylserine is preferentially imported for conversion to phosphatidylethanolamine, with ERMES and Vps39p facilitating this process.

The paper studies the binding and enzymatic activity of LD proteins using adiposomes, showing PI's effect on PLIN2 and ATGL.

The paper develops a fluorescent probe that changes emission lifetime upon aggregation, demonstrating potential for responsive imaging probes.

This paper engineers Escherichia coli to convert ethanol into acetyl-CoA and its derivatives through a heterologous pathway, achieving efficient ethanol consumption and production of PHB and prenol.

This study investigates the beampattern generated by resonance cavities in the Brown Long-Eared Bat and supports the hypothesis that frequency-driven sidelobe scanning arises from resonance in split cavities.

This study uses live-cell 3D single-molecule tracking to show that the NuRD complex decompacts chromatin and alters enhancer dynamics by increasing their movement and reducing time in a fast-diffusing state.

The paper develops a self-immobilizing NIR probe activated by SA-β-Gal for non-invasive imaging of senescence in mice.

This study shows that deletion of RgsA in Pseudomonas aeruginosa reduces growth and oxidative stress resistance in both planktonic and biofilm states.

This study develops an artificial sonar system inspired by the brown long-eared bat's vertical sound localization, showing that binaural conformation and orientation are critical for spatial target localization.

The paper uses cryo-EM to reveal the post-fusion structure of SARS-CoV-2, showing the S protein in a state with S1 disassociated.

The paper detects hydrogen evolution and absorption in plasma membrane vesicles of higher plants using spectrophotometry, gas chromatography, and H2 sensors, revealing bidirectional H2 activity.

This study examines how hypoxia affects gene expression in endometrial and decidual stromal cells, identifying transcriptional changes linked to endometriosis.

The paper identifies two distinct mechanisms by which small molecules inhibit LpxA acyltransferase, a key enzyme in lipopolysaccharide biosynthesis.

This study identifies two small-molecule inhibitors of LpxA, revealing distinct inhibition mechanisms and highlighting compound 2's improved properties for antibacterial development.

This paper proposes an electrostatic-interaction-based mechanism for prion protein refolding from PrPC to PrPSc, identifying key steps involving hydrophobic interactions and pH changes.