X. Ma

This study develops a reversed paired-gRNA plasmid cloning strategy to eliminate plasmid instability caused by direct repeats, achieving efficient genome editing in E. coli.

This study identifies miRNA193 in exosomes as a mediator of cisplatin resistance in esophageal cancer cells by regulating the cell cycle and inhibiting apoptosis.

This study investigates CDK1 paralog specializations in Oikopleura dioica, showing diversification under positive selection and functional subdivision along the S-M-phase axis.

This study introduces a new teaching method for medical statistics called PDTR, which improves student performance and reduces class hours compared to traditional methods.

This study identifies NMNAT as a chaperone that prevents phosphorylated Tau aggregation in vitro and reduces pathology in a fly model.

This study compares protein metabolism and regeneration in diaphragm and gastrocnemius muscles of hibernating and summer-active Daurian ground squirrels, finding distinct regulatory patterns contributing to hypertrophy and atrophy.

This paper improves pulcherriminic acid production in Bacillus licheniformis through multistep metabolic engineering, achieving a record yield of 556.1 mg/L.

This study identifies 26 gut microbiome biomarkers associated with schizophrenia and links specific bacterial species, like Streptococcus vestibularis, to altered neurotransmitter levels and behavioral changes in mice.

This paper demonstrates that CRISPR-Cas9-assisted native end-joining editing can efficiently knock out large genomic regions in E. coli without exogenous repair systems.

RhizoVision Crown is an open-source platform for high-throughput root crown phenotyping in crops, validated with simulated images and used on soybean and wheat, showing species-specific heritability.

The paper examines the roles of three wheat glutamine synthetase isozymes in nitrogen assimilation and translocation, showing distinct functions and synergistic effects.

This study shows that the Gly129 residue in FMDV-VP3 enhances viral pathogenicity by promoting apoptosis and autophagy through p53 interaction, and this residue is conserved across picornaviruses.

This study examines the assembly properties of SyFtsZ from Synechocystis sp. PCC 6803, identifying different protofilament structures formed in GTP and GDP conditions.

The paper identifies IL-24 as an anti-apoptotic factor in liver ER stress, showing its role in preventing cell death and its clinical relevance in acute liver failure.

This study characterizes and repurposes the endogenous Type I-F CRISPR-Cas system of Zymomonas mobilis to create an efficient genome engineering toolkit with 100% efficiency in various genetic modifications.

This paper develops virus-like vesicles (VLV) expressing multiple HBV antigens for immunotherapy of chronic hepatitis B, showing 40% efficacy in a mouse model.

This study shows that the tomato NAC transcription factor NOR controls leaf senescence, with similar regulatory roles in fruit ripening.

The paper studies how the fungal plant pathogen Zymoseptoria tritici responds to environmental stresses by changing its morphology, identifying new morphotypes and their adaptive significance.

This study identifies and genotypes Trichosporon species isolated from giant pandas, finding 11 species with varying pathogenicity and genotypes.

This study identifies a novel maize gene, glossy6, involved in epicuticular wax trafficking and drought tolerance by analyzing a mutant with reduced wax load and increased water loss.

This paper introduces a tumor-specific causal inference framework to identify causative somatic genome alterations and their impact on molecular phenotypes in individual tumors.

This study analyzes 255 chronic osteomyelitis patients in northern China, finding higher prevalence in males aged 41-50, common infection sites, and better outcomes with two-stage debridement and antibiotic-loaded PMMA beads.

The paper introduces a method to analyze single-cell variants in leukemia, finding structural variations precede single nucleotide changes in cancer development.

This study characterizes the molecular landscape of pediatric AML, identifying age-specific mutations and fusion oncoproteins that differ from adult AML.