X. Ma

This paper shows that teicoplanin inhibits SARS-CoV-2 cell entry by blocking cathepsin L proteolytic activity, effective against multiple variants with IC50 values of 2.038 M and 2.116 M.

This study shows that music increases protein content and photosynthetic efficiency in duckweed and activates Glu and Ca signaling, with transcriptomic changes linked to metabolic pathways.

This study identifies SLC15A4 as a regulator of inflammasome function in dendritic cells by linking phagocytosis to mTORC1 signaling and autophagy inhibition.

The paper shows that deleting IGF2BP1/IMP1 enhances autophagy and tissue regeneration by regulating MAP1LC3B through phosphorylation and cell stress.

This study shows NSD2 E1099K mutation disrupts 3D chromatin organization in B-ALL, leading to drug resistance and clonal evolution through compartmentalization changes.

This paper designs and synthesizes SPIO-HGNS nanoparticles with tunable SPR in the NIR range to enhance photothermal conversion for potential photothermal therapies.

This study determines the cryo-EM structures of AAV9 and AAVPHP.eB in complex with their receptor AA VR, revealing molecular details of receptor recognition and explaining enhanced CNS transduction.

This paper identifies septins as key regulators of amoeboid motility in T cells by enabling microenvironment sensing and actomyosin partitioning through steric interactions with collagen fibers.

The paper demonstrates mating between haploid cells with human GPCRs and enables hGPCR signaling in probiotic yeast using transcriptome analysis and ligand-free screening.

This paper introduces a method for real-time single-molecule protein sequencing using a semiconductor device, capable of detecting peptides and post-translational modifications with high sensitivity.

The paper shows phosphoantigens glue BTN3A1 and BTN2A1 together, initiating gamma-delta T cell activation through intracellular signaling.

This study investigates how homoeologous exchange affects gene expression and alternative splicing in synthetic allotetraploid wheat, finding cis- and trans-regulatory impacts on gene expression and AS events.

This paper develops a RHAMMB-targeting nanoparticle delivering siBcl-xL and KLA peptide to treat PNETs, showing synergistic tumor reduction in mice.

This paper develops a vascular bundle detection model for Phyllostachys and finds consistent radial gradient patterns across 29 species.

This paper introduces a novel COVID-19 vaccine based on a RBD-HR1/HR2 hexamer structure that induces high neutralizing antibody titers and alternative antibodies targeting the HR1 region in mice.

This study identifies a novel family of RNA-binding proteins in Bacteroides thetaiotaomicron that regulate polysaccharide metabolism by controlling gene expression in response to dietary sugars.

This study examines the physiological responses of Solenaia oleivora to short-term salinity exposure, showing changes in hemolymph osmolality, protein and amino acid concentrations, ion levels, and gill morphology.

This study shows that exosomal miR-140-3p from diabetic BMSCs promotes bone restoration in diabetic rats by enhancing osteogenesis and inhibiting the plexin B1 signaling pathway.

This paper introduces a high throughput single-cell pipeline for bispecific antibody discovery, demonstrating its efficiency in identifying rare functional clones and uncovering design principles for improved immunotherapeutics.

This study sequenced and analyzed 11 ocular trauma-sourced S. epidermidis genomes, identifying 10 potential biomarkers and revealing pathogenic strains may be independent of biofilm formation.

This study compares proteomic profiles of vancomycin-intermediate resistant S. aureus strains to identify differentially expressed proteins associated with vancomycin resistance.

This study shows YAP1 is essential for bile duct development and reveals hepatocyte adaptation in its absence.

This study shows TRAF2 regulates mitophagy and inflammation in cardiac myocytes to prevent cell death and maintain homeostasis.

The paper identifies a new ERGIC-ERES membrane contact mediated by TMED9 and SEC12 that is essential for autophagosome biogenesis under stress.

This study generates new cell lines for undifferentiated pleomorphic sarcoma and malignant peripheral nerve sheath tumor to better study sarcomagenesis and develop therapies.

The paper determines the structure of the V2 vasopressin receptor bound to AVP and Gs, revealing how AVP activates the receptor and providing insights for drug design.

This study uses CRISPR/Cas9 to induce homology-independent targeted integration in a rat hemophilia B model, achieving therapeutic correction with 3.66% knock-in efficiency and normalization of clotting time.

The paper identifies a novel SARS-CoV-2-related bat virus, PrC31, with complex recombination events and partial genetic similarity to SARS-CoV-2.

This study challenges the idea that hydrogen's antioxidant properties are its main biological function by showing limited hydroxyl radical scavenging and suggesting alternative mechanisms.

This study identifies PEAK3 as a pseudokinase that promotes cell migration and invasion through scaffolding interactions and tyrosine phosphorylation.