X. Wu

This study profiles the tumor immune microenvironment of NSCLC using multiplex immunofluorescence, identifying three immune subtypes and an immune-related risk score for prognosis prediction.

This study visualizes the structural progression of the cytokinetic contractile ring in sea urchin embryos, showing myosin II clusters with anillin and septin, and the formation of a septin filament network.

This study constructs high-resolution spatial transcriptomes of primary liver cancers to analyze spatial architecture and identify tumor microenvironment features.

This paper introduces a multiview super-resolution microscopy approach that enhances confocal microscopy resolution and reduces phototoxicity across multiple scales.

This study identifies two non-coding A-to-T mutations at the Kozak site of the N gene as potentially contributing to the transmissibility of Alpha, Delta, and Omicron SARS-CoV-2 variants.

This study shows that high oxygen tension upregulates integrin α6 in nucleus pulposus cells, which protects against intervertebral disc degeneration by reducing apoptosis and oxidative stress.

This paper develops a p-ELISA method using a multiepitope fusion protein to diagnose bovine and goat brucellosis, achieving high sensitivity and specificity.

This study uses time-sequential miRNA expression data from a mouse AML model to identify state transitions during leukemogenesis and shows the model predicts time to AML development.

The paper uses single unit analysis and wide-field imaging to study excitatory and inhibitory neuron alterations in glioma, finding mTOR inhibition reverses these changes.

This study investigates how nanoparticles exchange between cells, showing that extracellular vesicles significantly facilitate this process.

The paper shows that complement activation is higher in severe SARS-CoV-2 infection compared to influenza and non-COVID respiratory failure, with the alternative pathway linked to worse outcomes.

This paper describes an AAV-mediated in vivo CAR gene therapy that generates CAR T cells within the host, leading to tumor regression in a humanized mouse model.

Nb15-NbH-Nb15, a bispecific nanobody with a heterotrimeric configuration, showed potent neutralization of SARS-CoV-2 in vitro and provided complete protection against infection in hACE2 mice via intranasal administration.

This study shows that the cationic peptide L-K6 enhances doxorubicin's effectiveness in drug-resistant cancer cells by inhibiting P-glycoprotein function and expression.

This study shows that FGF21-PEG normalizes plasma glucose in two mouse diabetes models, even when insulin receptor function is impaired.

This paper develops a non-viral method for efficient T cell genome editing using modified plasmids, achieving CAR-T cell functionality comparable to AAV-based methods.

This study investigates the tumor-suppressing functions of hsa-miR-654-5p in lung cancer through bioinformatic analysis and in vitro experiments, revealing its role in inhibiting EMT, proliferation, and migration.

This study shows that complex natural organic carbon sources better enrich diverse subsurface bacteria than simple organic sources.

The paper identifies a novel dermal migratory Langerhans-like cell population using fate mapping and single-cell RNA sequencing, showing distinct migration and replenishment characteristics compared to Langerhans cells.

The paper identifies a genetic variant that increases SARS-CoV-2 receptor expression and susceptibility, and shows a JAK inhibitor reduces this risk.

This study shows that calorie restriction affects gut microbiome, which in turn influences metabolism, hormones, and brain function in obese individuals.

The paper compares embryo proper and suspensor transcriptomes across plants with different suspensor morphologies, identifying shared and specific transcription factors involved in early embryo differentiation.

The paper compares HIV integration site distributions in vivo and in vitro to assess the role of oncogene integration in viral persistence during ART.

The paper identifies a metabolic coincidence mechanism in Arabidopsis that controls winter photoperiodism, independent of the canonical CO/FT pathway.

This study uses GaMD simulations to elucidate the dynamic mechanism of Numb RNA binding to MSI1, providing insights for drug design targeting this interaction.

This study finds adolescents cooperate less than adults in social dilemmas due to lower intrinsic reward for reciprocity, not poor expectation of others' cooperation.

This paper develops a SARS-CoV-2 proteome microarray to analyze antibody interactions at amino acid resolution and identifies epitopes and neutralizing antibodies in COVID-19 patients.

This study systematically analyzes peroxiredoxins (PRDXs) across 33 cancer types, examining expression, genetic alterations, methylation, prognosis, pathways, and drug targets, with validation of PRDX6's role in bladder cancer cell proliferation via JAK2-STAT3 pathway.