X. Yang

This study shows that PKR inhibition reduces mitochondrial dysfunction and ameliorates HIV-associated nephropathy in transgenic mice using single-nucleus and bulk RNA-seq.

The paper identifies a CD8 T cell population, QFL T cells, restricted to MHC-E that develops independently of classical MHC I and requires Qa1b for agonist selection and functionality.

This study identifies 16 cuproptosis-related molecules and develops a scoring system to predict prognosis, tumor immune microenvironment, and immunotherapy response in colorectal cancer.

This study identifies two broadly neutralizing antibodies against SARS-CoV-2 variants and shows their synergistic neutralization effect, supported by cryo-EM structures.

This study shows that initial niche conditions determine the aging speed and regenerative activity of quiescent fission yeast cells, with regenerative activity declining linearly before survivability.

This study identifies mitochondrial Ca+2 dysregulation via MAM-STAT3 as a driver of immunosenescence in type A mandibuloacral dysplasia.

This study shows that co-infection with Ehrlichia and Borrelia burgdorferi in mice causes arthritis and emergency myelopoiesis, highlighting immune signals over pathogen burden in disease development.

This study investigates the role of PdWND1B in Populus wood formation and biofuel conversion by over-expressing or silencing it, showing effects on biomass, cell wall composition, and sugar release efficiency.

SIC50 uses a vision transformer and Sobel operator to determine IC50 from phase-contrast images, validated with four drugs and 1536-well plates.

This study examines how chromium stress affects bacterial community structure and diversity in the rhizosphere soils of Iris pseudacorus using 16S rRNA sequencing.

The paper identifies ID1 as an autonomous phosphate regulator that modulates the miR399-ZmPHO2 signaling module to maintain Pi homeostasis in maize.

This study shows that early life stress increases female mice's susceptibility to metabolic dysfunction and pain when exposed to a high-fat/high-sucrose diet.

This study identifies FOXP2 as an oncogene in prostate cancer that activates MET signaling, promoting tumorigenicity through both full-length and truncated forms.

The paper investigates how phase separation of N-myc affects gene transcription and finds that only a small fraction of N-myc-regulated genes are influenced by this process.

The paper tests the translation-compensation and growth rate hypotheses for temperature effects on marine bacterioplankton resource allocation in lab cultures and field samples.

This study generates functional posterior spinal motor neurons from hPSCs-derived neural progenitor cells, demonstrating efficient differentiation and functional maturity.

This study links gut microbial depletion of Lachnospiraceae genera to lower HDL-C and hypertension in a high-calorie diet population, suggesting HDL-C as a mediator.

The paper discovers novel inhibitors of HsMetAP1 from metagenomic data using computational and synthetic biology methods.

The paper identifies Muribaculaceae family bacteria as pathobionts that induce insulin-dependent diabetes in mice through translocation to the pancreas following gut microbiota disruption.

The paper identifies a rice mutant with reduced magnesium uptake and translocation, linking it to a novel zinc-finger gene OsRZF1 involved in magnesium homeostasis.

This study identifies BapR, a bile acid-sensing transcription factor in C. difficile, using chemical proteomics and shows it regulates gene expression in response to lithocholic acid.

This study identifies a novel interaction between SARS-CoV-2 spike protein and estrogen receptor alpha, showing its role in modulating ER activity and ACE2 expression in infected cells and tissues.

This study shows that lactational exposure to Triclosan in mice causes fatty liver disease by disrupting metabolic pathways involving PERK-eIF2-ATF4-PPAR.

The paper compares immunological characteristics of SARS-CoV-2 vaccine non-responders aged 18-59 and 60+ to identify factors associated with seroconversion and recommend booster vaccinations.

This study creates Aegypti-Atlas, a transcriptomic resource for Aedes aegypti, revealing gut regional specializations and immune responses in sugar-fed and blood-fed females.

This paper reports a synthetic nanobody, C5G2, that neutralizes SARS-CoV-2 and Omicron variants with high potency through a unique binding mechanism.

This study compares IL13-ligand CAR designs to determine how co-stimulation domains affect tumor selectivity and anti-tumor activity against glioblastoma.

This study shows miR-138 suppresses HSV-2 lytic infection by targeting viral and host genes, with distinct mechanisms compared to HSV-1.

This study identifies XPO1 inhibition with selinexor as a potential therapy for favorable histology Wilms tumors, showing synergy with doxorubicin in preclinical models.