Y. Du

The paper shows ATFS-1 promotes {Delta}mtDNA replication by recruiting POLG, while LONP-1 inhibition increases wildtype mtDNA binding and improves heteroplasmy ratio and OXPHOS function.

This study identifies AATRhg1 as an amino acid transporter that increases in abundance during soybean cyst nematode penetration and interacts with GmRBOHC2 to enhance ROS production, contributing to resistance.

This study identifies cadherin-11 as a mediator of cancer cell hijacking of fibroblasts post-EMT, enhancing invasion and metastasis in solid tumors.

The paper identifies mutanofactin-697, a secondary metabolite from S. mutans, which promotes biofilm formation by increasing bacterial hydrophobicity and adhesion.

This study classifies bladder cancer patients into immune and non-immune groups using NMF and NTP algorithms, finding immune-activated patients respond better to anti-PD-1 therapy.

The paper discovers a new family of natural products, clostyrylpyrones, from Clostridium roseum and proposes their polyketide synthase-based biosynthesis mechanism.

The paper shows that the mitotic kinase Polo also directs cellular morphogenesis after cell cycle exit, with its activity regulated by different upstream kinases during mitosis and post-mitosis.

This paper uses native mass spectrometry to study how heparin disrupts the SARS-CoV-2 spike protein's interaction with ACE2, providing insights into its potential as a repurposed therapeutic for COVID-19.

This study investigates the cardiac electrophysiological effects of hydroxychloroquine and azithromycin, showing they prolong QT intervals and increase arrhythmia risk when combined.

The paper investigates how HetR controls gene expression from DIF1 motif promoters during heterocyst differentiation, showing dependence on HetZ and modulation by PatU3.

This paper identifies two ER proteins, LRMP and IRAG, that modulate HCN4 channel function differently, with LRMP inhibiting and IRAG enhancing HCN4 activity in a cAMP-independent manner.

This paper presents full-length transcriptome data of Ascosphaera apis mycelium and spore using PacBio SMRT sequencing, providing high-quality transcripts for genome and transcriptome annotation improvements.

This study develops a method to mature hiPSC-CMs, enabling them to model adult-onset cardiovascular disease like hypertrophic cardiomyopathy.

This paper identifies and characterizes 359 RXLR effectors in nine Pythium species, revealing evolutionary patterns and functional roles in host interactions.

This study evaluates moxifloxacin efficacy against Mycobacterium abscessus in a zebrafish model, finding limited in vivo activity despite good in vitro results.

The paper profiles the fitness landscape of HIV-1 protease resistance mutations and finds that positive epistasis is predominant, reducing the likelihood of reversing drug resistance mutations.

The paper shows that iron-deficiency and estrogen increase transferrin, leading to hypercoagulability and worsened ischemic stroke.

This paper revisits the Fisher-KPP model to provide new insights into the spreading-extinction dichotomy by analyzing its travelling wave solutions and their relationship to the Fisher-Stefan model.

This paper introduces a novel reporter gene assay for pyrogen detection using NF-κB activation in RAW 264.7 cells, showing sensitivity and applicability to various biological products.

This paper develops a bile duct-on-a-chip that mimics bile duct structure and barrier function, enabling studies of cholangiocyte permeability and toxin effects.

This study identifies four key anatomical and functional differences between neonatal and adult mouse extrahepatic bile ducts that may explain their susceptibility to injury.

This study identifies surface proteins of Lactobacillus pentosus HC-2 as essential for its probiotic effects in shrimp midgut using proteomic analysis.

This study shows that local membrane charge affects β2AR coupling to Gi and Gs proteins, with negative charges inhibiting Gi coupling and promoting Gs coupling.

This study identifies a novel maize gene, glossy6, involved in epicuticular wax trafficking and drought tolerance by analyzing a mutant with reduced wax load and increased water loss.

This study identifies the role of N-linked glycosylation in ZIKV E protein function across mosquito and human cells using a mutant library.

The paper introduces DeBias, a method to separate global biases from local interactions in cell biology data, showing global bias contains mechanistic insights.