Y. Jiang

This study investigates how TSG promotes osteogenic differentiation of BMSCs by inhibiting KDM5A expression.

This study presents EM structures of the human mitochondrial calcium uniporter holocomplex with and without Ca2+, showing how Ca2+ affects its assembly and channel pore blockage.

The paper identifies AMPK substrates and their roles in DNA damage response and histone acetylation through phosphoproteomics and histone modification analysis.

This study shows berberine reverses multidrug resistance in Candida albicans by hijacking the Mdr1p efflux pump for drug import, leading to mitochondrial dysfunction and selective cell death.

This study compares gut metagenomes across 10 vertebrate species to identify conserved and variable microbial functional pathways, showing general similarity to human gut microbiomes but with notable differences in disease-related pathways.

The paper determines the structure of SARS-CoV-2 Mpro and shows how GC376 inhibits its catalytic site, supporting its use as an antiviral drug.

This paper investigates how fentanyl activates the mu-opioid receptor through beta-arrestin biased signaling using molecular dynamics simulations and validates findings with synthesized compounds.

This study shows that paracetamol enhances decitabine's anti-tumour effects by increasing oxidative stress without worsening DNA damage.

This study shows rottlerin reduces DSS-induced colitis in mice by enhancing intestinal barrier function through the Epac-2/Rap-1 signaling pathway.

This study analyzes SARS-CoV-2 genome data to infer its evolution and population demography using phylogenetic and population genetics methods.

The paper develops a queuing model of stochastic transcription using non-exponential waiting-time distributions to better capture gene expression dynamics and shows that reduced waiting-time noise can increase mRNA noise.

This study identifies altered B cell subset homeostasis in IgAV patients, with increased plasmablasts and decreased specific memory B cells, correlating with IgA levels.

This paper identifies a novel protein complex in Arabidopsis that regulates ROS1-mediated active DNA demethylation and targets ROS1 to specific genomic regions.

The paper investigates the genetic basis of rumen evolution by comparing transcriptomes and genomic data across ruminants, camels, and cetaceans, identifying key genetic innovations.

This study shows that mechanical alignment of actin filaments precedes chemical changes during bundle formation in response to tensile force.

This paper introduces a new single-molecule force spectroscopy method that stretches DNA to twice its normal length under high tension.

This study compares gut microbiota composition between healthy and rotten-skin diseased giant spiny frogs using 16S rRNA sequencing and identifies significant microbial abundance differences.

This study identifies YSL3-mediated copper transport as critical for fertility, grain yield, and size in Brachypodium, with implications for improving crop production in copper-deficient soils.

This paper characterizes an ammonia-tolerant ammonia-oxidizing archaeon from vegetable soil, identifying genomic and physiological mechanisms underlying its high ammonia tolerance.

This study investigates the transcriptome changes in grass carp brains under low temperature, identifying key pathways and genes involved in cold acclimation.

The paper examines insulin signal transduction in the retina of db/db mice, finding impaired signaling marked by increased TNF and IRS-1 phosphorylation and reduced Akt phosphorylation.

This paper derives general forms of fluorescence correlation spectroscopy (FCS) and photon counting histogram (PCH) for bounded systems, enabling accurate quantification of molecular kinetics in finite domains.

The paper investigates interactions between germline and somatic variants in the p53 pathway to show their combined effects on cancer risk, progression, and treatment response.

This study identifies TP63, SOX2, and KLF5 as core regulatory circuitry transcription factors in ESCC that drive epigenetic modifications and tumor growth through super-enhancer interactions.

The paper reports the structure of arrestin-2 bound to neurotensin receptor 1, revealing a novel orientation that enables coupling to GPCRs lacking a C-terminal tail.

This study shows that Coxiella burnetii phase II can grow under normoxic conditions in ACCM-2 with tryptophan, and its transformant grows robustly without tryptophan, suggesting tryptophan and a temperature-sensitive signal are involved in normoxic growth.

The paper compares subgenome asymmetry in artificial and natural allopolyploid genotypes, finding that variable genome components influence subgenome differences and suggest their consideration in polyploid evolution studies.

This study evaluates the methodological quality of animal studies using the SYRCLEs risk of bias tool, finding significant differences between Chinese and English studies.

This study isolates and identifies actinomycetes from soil samples in southwestern China, revealing high diversity and antimicrobial potential.

This study identifies that BTLA and PD-1 use distinct phosphatases to differentially repress T cell signaling, highlighting mechanistic differences between two co-inhibitory receptors.