Y. Li

This study analyzes the nutritional composition and transcriptome of early-stage Japanese eel larvae to understand their nutrient requirements and metabolic pathways.

This study uses Illumina sequencing to analyze genome diversity in siphonophores, revealing large nuclear genomes and rearranged mitochondrial genomes, identifying optimal species for future genomic work.

This study uses single-cell multi-omics to map epigenetic and transcriptomic changes in retinoblastoma, identifying key regulators and potential drug targets.

SeMOE enables absolute glycan quantification and visualization through selenosugar-based metabolic oligosaccharide engineering, with demonstrated anti-cancer potential.

The paper investigates how a small-molecule inhibitor binds to and inactivates Cbl-b, revealing a structural mechanism that locks the protein in an inactive conformation.

This study develops a theranostic gold nanoparticle for detecting and treating biofilm infections using photothermal ablation and photoacoustic imaging, showing superior efficacy against oral and wound infections compared to chlorhexidine.

The paper identifies a modular (L)WY-LWY motif in Phytophthora effectors that recruits host PP2A phosphatase, enabling phosphoprotein regulation through structural mimicry.

The paper demonstrates a cost-effective DNA metabarcoding workflow for large-scale insect biodiversity monitoring, estimating 31,846 species from Malaise trap samples across Germany.

The paper genetically manipulates Saccharibacteria from the CPR to study their role in epibiotic growth and develops bioinformatic resources for their analysis.

This study reports cryo-EM structures of AC5 with Gβγ and proposes a mechanism for its isoform-specific regulation, linking it to motor function and potential drug development.

This study determines the structure of PlsB from Themomonas haemolytica using cryo-EM, revealing three domains and their roles in membrane association, catalysis, and dimerization.

This study identifies CtBP2 as a mediator of Bcl-xL nuclear translocation, which promotes metastasis by enhancing H3K4me3 and TGFβ transcription.

This study identifies complement component 1q (C1q) as a macrophage-derived factor that regulates gastrointestinal motility by interacting with the enteric nervous system.

The paper identifies ATR2Cala2 as an effector recognized by four TIR-NLR immune receptors in Arabidopsis and shows their quantitative requirement for resistance to Hpa-Cala2.

The paper shows that salt stress modulates lateral root development through an auxin-independent pathway involving ZAT6 and LBD16.

This study establishes the Pig Virome Database (PVD) by mining global metagenomic data, revealing extensive viral diversity and functional potential in the pig gut.

This study finds that consuming traditionally fermented foods increases antibiotic resistance in gut microbiota, posing a public health risk.

This study shows that Disulfiram reduces pulmonary fibrosis by reactivating COX-2-mediated PGE2 synthesis in both cell and animal models.

This study shows that targeting FAP+CAFs in desmoplastic pancreatic tumors reduces stromal barriers, enhances T cell infiltration, and improves response to immunotherapy.

The paper identifies a novel MCR-1 variant with low β-lactam co-resistance and shows synthetic peptides from this variant have broad-spectrum antimicrobial activity.

This study shows that dietary calcium affects calcium content and transporter mRNA expression in mosquito Malpighian tubules, with dynamic changes during blood feeding.

This study shows that early microbial intervention in newborn calves reduces diarrhea and improves later milk production by altering gut microbiome composition and metabolite profiles.

The paper shows that dietary metabolites enhance CD8+ T-cell immunity against Cryptosporidium infection in mice by activating the AHR pathway.

This study presents haplotype-resolved genomes of triploid bananas, revealing subgenome asymmetric evolution and resistance mechanisms against banana wilt.

The paper shows that expanded intronic TNR repeats in IIL1 cause growth defects in Arabidopsis by increasing intron-retained transcripts and disrupting protein interactions essential for leaf development.

This study shows ANKRD49 promotes metastasis in NSCLC cells by activating the JNK-ATF2/c-Jun-MMP-2/9 pathway.

This study shows that Notch1's N1ICD forms transcriptional condensates via phase separation coupled percolation, enhancing target gene expression and enhancer looping.

This study shows that tolcapone causes embryo lethality and preeclampsia-like phenotypes in mice by inhibiting trophoblast migration and invasion.

This study identifies HIF2/ARNT as a protective axis in cardiac endothelial cells post-MI, preventing vascular leakage and inflammation through suppression of IL6.

This study identifies an amino acid difference that stabilizes interdomain interactions in Gi1 but not Gi2, leading to differences in effector activation and signaling specificity.