Y. Liu

The paper analyzes SARS-CoV-2 variant frequencies using 500,000 whole-genome sequences, finding that mutations within variants do not rise in unison, suggesting multiple distinct variants.

This study identifies a fungal oxylipin analogous to jasmonic acid as a morphogenetic signal that triggers pathogenic development in Magnaporthe oryzae by interacting with cyclic AMP and redox signaling.

This study shows that HDAC5 deacetylates IFIT2, promoting glioma stemness and progression by inducing IFIT2 ubiquitination and loss of anti-tumor activity.

This study uses meta-analysis of DNA microarray data to identify gravity-sensitive genes, finding that SLCO2A1 expression decreases under microgravity.

This paper introduces Protein-SIP, an ultra-sensitive method for quantifying isotope incorporation in microbiomes, showing higher sensitivity and accuracy than existing approaches.

This study sequenced and compared the genomes of two Sphingomonadaceae strains, revealing shared lutein synthesis genes and unique genes for hepatotoxin degradation in Sphingopyxis USTB-05.

This study identifies norstictic acid as a selective allosteric inhibitor of Med25-mediated transcriptional interactions, showing its effect in vitro and in a breast cancer model.

This paper introduces OSIV, a technique for quantitative blood flow vector mapping in vivo, demonstrating its ability to measure absolute flow velocity and direction without tracers or high-speed cameras.

This study uses CRISPR/Cas9 to induce homology-independent targeted integration in a rat hemophilia B model, achieving therapeutic correction with 3.66% knock-in efficiency and normalization of clotting time.

This study examines how Saccharina japonica and Sargassum horneri respond to ocean acidification and eutrophication, finding that S. horneri has competitive advantages under combined stress.

This study examines the kinetic response of B-cell receptor (BCR) repertoire diversity and lineage expansion in non-human primates after TLR7/8 stimulation, finding that TLR7/8 selectively expands high-mutation, low-frequency IgKL lineages.

This study identifies pDC-AML as a distinct AML subset with high RUNX1 mutations and pDC transcriptional features, suggesting CD123 targeting as a therapeutic strategy.

This study compares cytokine, chemokine, and growth factor profiles in saliva and gingival crevicular fluid from healthy donors to determine which fluid is better for biomarker development.

This study evaluates how N-linked glycans on Lassa virus GPC affect immune response, finding that glycan deletion enhances effector T cell proportions and antibody titers, suggesting potential for vaccine design.

The paper shows the N501Y spike mutation in SARS-CoV-2 enhances viral transmission in hamsters and human airway cells by increasing receptor binding affinity.

The paper develops a chemical probe, UNC6934, that targets the PWWP1 domain of NSD2, revealing cooperative control of NSD2 localization through chromatin reader domains.

The paper analyzes T-cell receptor repertoires in different phases of COVID-19 to identify immune response patterns and predict recurrent infection risk.

This study shows that H3K36 methylation and DNA-binding by Ioc4-PWWP domain are essential for Ioc4 recruitment and Isw1b chromatin remodelling function.

This study identifies C28 as a compound that modulates IKs channel voltage sensor activation, reversing drug-induced APD prolongation without affecting normal APD.

This study shows that hibernating ground squirrels recycle urea nitrogen through their gut microbiome to maintain protein balance during winter fasting.

This study shows that apoptotic extracellular vesicles (apoEVs) protect liver homeostasis and regeneration by forming a chimeric organelle with the Golgi apparatus and restoring hepatic ploidy.

The paper identifies a 32-gene signature specific to Ewing sarcoma and shows that LOXHD1, a stereociliary protein, is a key driver of malignancy through its regulation by EWSR1-FLI1.

The paper develops a D-2-hydroxyglutarate biosensor using DhdR, which detects D-2-HG in biological samples with high specificity and sensitivity.

The paper assesses SARS-CoV-2-specific cellular immunity by testing T cell responses to viral antigens and shows varied immune responses and the potential of antigen stimulation to enhance immunity in non-responders.

This study identifies histone modification genes critical for Candida glabrata's resistance to host defense peptides and caspofungin, and their role in virulence.

The paper develops 3D live microscopy to track Bacillus subtilis interactions with lettuce roots in soil, revealing new patterns of bacterial movement and colonization.

This study develops genetic mouse models of latent tuberculosis, revealing that adaptive immunity differentially controls relapse depending on the model used.

This study shows O-GlcNAc modification of MTA1 enhances its chromatin binding and transcriptional activity, aiding breast cancer cells in adapting to genotoxic stress.

Nb15-NbH-Nb15, a bispecific nanobody with a heterotrimeric configuration, showed potent neutralization of SARS-CoV-2 in vitro and provided complete protection against infection in hACE2 mice via intranasal administration.