Y. Liu

This study identifies AK-778-XXMU as a potent ID2 antagonist with potential as a glioma therapeutic through pharmacophore-based virtual screening and experimental validation.

The paper uses cryo-EM and AlphaFold2 to determine the structure of SARS-CoV-2 Nsp2, revealing its zinc-binding site and potential interactions with host proteins.

This study shows benzydamine enhances tetracycline antibiotics' effectiveness against drug-resistant bacteria by disrupting membrane potential and increasing drug uptake.

This study shows that OCTR-1 in C. elegans neurons regulates temperature-dependent longevity by modulating immune response genes.

This study shows that NMUR-1 regulates C. elegans innate immunity specificity by modulating transcription factor activity and immune gene expression in response to pathogens.

The paper shows auxin's biphasic control of cell expansion coordinates hypocotyl elongation and apical hook formation in etiolated seedlings.

This study identifies four residues in Lassa virus GP1 critical for receptor switch to LAMP1, showing their impact on binding affinity and infectivity.

This study uses long-read sequencing to show DNA methylation affects pre-mRNA splicing, poly(A) tail length, and gene silencing in Arabidopsis.

This study shows that Smad4 loss promotes lung cancer metastasis by upregulating PAK3 through miRNA regulation, suggesting Smad4 LOF as a prognostic marker and therapeutic target.

This study uses crystal structures of the σ2 receptor to dock and screen a large library, identifying new chemotypes with high affinity and selectivity for the receptor.

The paper identifies a novel aerobic anoxygenic phototrophic bacterium, strain B3, capable of photoautotrophy via the Calvin-Benson-Bassham cycle using sulfite or H2 as electron donors.

This paper investigates the effects of S-Licarbazepine on SCN8A variants in neuroblastoma cells, showing variant-specific modulation of NaV1.6 channel biophysical properties.

This study investigates cell-type apoptosis in lung tissues during SARS-CoV-2 infection, finding both intrinsic and extrinsic apoptotic pathways are activated, while some cell types remain refractory to infection.

This study investigates how EPAC1 regulates rickettsial adhesion to endothelial cells by modulating ANXA2 Y23 phosphorylation, using in vivo models and FluidFM.

This study analyzes rabies virus variants from ferret badgers in China, identifying four lineages and assessing their pathogenicity and distribution.

This study shows that rat mesenchymal stem cells express Ang1 and Ang2, which are upregulated during osteogenesis in vitro.

This study introduces three new tract-related strain measures to improve concussion prediction in finite element head models by analyzing white matter deformation during impacts.

This study examines soil bacterial and fungal community patterns and co-occurrence networks along depth and altitude gradients in cold-temperate forests, finding altitude has a stronger impact than depth.

This paper describes an engineered contact lens that passively releases lifitegrast for up to 10 hours, achieving therapeutic concentrations to treat dry eye syndrome.

This study investigates how Pseudomonas aeruginosa adapts and evolves during coinfection with COVID-19, showing it overexpresses alginate and reduces Type VI secretion system to enhance biofilm formation and suppress virulence.

This study identifies Vibrio cholerae in diseased bullfrogs and suggests it can transmit to humans via bullfrog food and aquaculture water, posing a health risk.

This study identifies novel SARS-CoV-2 receptors through a CRISPR activation screen, revealing LDLRAD3, TMEM30A, and CLEC4G as functional receptors independent of ACE2.

This study isolates and characterizes Helcococcus ovis from clinical bovine mastitis in China, showing its antimicrobial sensitivity and pathogenic potential in a murine model.

The paper examines how non-structural carbohydrates (NSCs) and fine root traits vary across root branch orders in Fraxinus mandshurica seedlings under different drought and soil conditions.

This study identifies unbalanced dietary patterns as contributors to precocious puberty by altering gut microbiota and host metabolites, with biomarkers showing high diagnostic accuracy.

This study shows that viral proteins interact combinatorially, leading to new biological functions beyond their individual roles during infection.

This study identifies key genes and regulatory networks in flavonoid metabolism of Rosa roxburghii using transcriptome analysis and WGCNA.

The paper identifies a MAP-like motif in Sept9 isoform 1 that drives septin-microtubule interaction and shows how HNA mutations disrupt this association.