Y. Liu

The paper presents 52 high-quality genomes of rumen ciliates, reclassifying them into 19 species and identifying their biomass-degrading enzymes.

The paper shows that neural stemness unifies tumorigenicity and pluripotent differentiation potential by demonstrating SETDB1's role in maintaining these properties through epigenetic and transcriptional mechanisms.

This study shows that the PIKA-adjuvanted SARS-CoV-2 spike protein vaccine YS-SC2-010 maintains high neutralizing activity against Omicron and other variants for up to 596 days post-vaccination in animal serum.

This study shows that bacterial amino acid biosynthesis prevents rhizosphere alkalization and immune activation in Arabidopsis by reducing glutamate precursors.

This study shows that UTX promotes glioblastoma progression by upregulating periostin expression, and its knockdown inhibits tumor growth and promotes apoptosis.

This paper identifies TS-984 as a potent inhibitor of the SARS-CoV-2 spike protein-ACE2 interaction through a high-throughput screening platform and in vitro validation.

This study examines neuromast evolution and distribution in Sinocyclocheilus cavefish, finding asymmetry and convergence in cave-adapted species with distinct wall-following behaviours.

This study identifies SlBES1.8 as a tomato transcription factor that promotes leaf simplification by modulating gibberellin metabolism and signaling.

This study shows that combining mRNA vaccines targeting the SARS-CoV-2 spike and nucleoprotein proteins enhances protection against the delta variant in animal models.

This study uses computational models to show that the temporal horn increases hippocampal vulnerability during head impacts by increasing strain and strain rate in specific subfields.

This study constructs a single-cell transcriptome atlas of multiple myeloma patients stratified by R-ISS, identifies PC subsets and immunotargets, and links them to prognosis and EBV infection.

This paper uses monoclonal antibodies to study the conformation and localization of the SARS-CoV-2 spike protein's receptor-binding domain in infected cells, revealing its presence in the Golgi complex and its role in cell-to-cell transmission.

This study identifies three FDA-approved drugs that inhibit Lujo virus entry by targeting the envelope glycoprotein's transmembrane domain and calcium channels.

The paper shows that clathrin facilitates CV-containing vesicle budding from chloroplasts, while GAPC inhibits this process and affects stress responses.

This study identifies key epigenetic states and transcription factor networks in human alveolar epithelial differentiation, revealing dynamic enhancer changes and regulatory interactions critical for distal lung identity.

The paper uses DC-iDEP to isolate insulin vesicles from pancreatic β-cells and identifies distinct distribution patterns in response to glucose stimulation.

The paper identifies MAR1 as a membrane protein essential for membrane adhesion preceding lipid bilayer merger during fertilization in Chlamydomonas.

This study shows that SARS-CoV-2 S2-targeted vaccination induces broad neutralizing antibodies against multiple coronaviruses and provides better protection than homologous boosting.

This study shows dihydroartemisinin (DHA) enhances anti-PD-1 therapy in hepatocellular carcinoma by inhibiting YAP1 and disrupting immune evasion through PD-L1, JAK1/STAT1, and JAK3 pathways.

This study identifies a resident state in influenza polymerase that enables smooth transitions between transcription and replication cycles through structural analysis.

This study investigates the physiological roles of short-chain and long-chain menaquinones in Lactococcus cremoris by analyzing mutant strains with altered MK profiles under different growth conditions.

This study shows that Ser68 phosphorylation is essential for CENP-A deposition, centromere function, and mouse viability.

This paper develops a portable 3D microfluidic chip for rapid single-cell antibiotic susceptibility testing and bacterial quantification, showing improved speed, sensitivity, and accuracy compared to traditional methods.

The paper develops smart soils made from fluoropolymer waste to monitor rhizosphere chemical dynamics, enabling faster genetic and agrochemical screening.

This study examines how habitat and phylogeny shape gut microbiomes in Sinocyclocheilus cavefish, finding habitat is the main driver, with captivity homogenizing microbiomes across species.

ReCOV, a trimeric SARS-CoV-2 subunit vaccine, induced neutralizing antibodies and complete protection against SARS-CoV-2 in mice and rhesus macaques.

This study compares alpha-synuclein fibril structures from preclinical and postmortem Parkinson's disease patients, showing structural and pathological differences in fibril conformation during disease progression.

This study identifies two distinct H3 binding modes of NASP and shows how they cooperate to maintain histone H3-H4 homeostasis.

This study identifies AI-2 as a quorum sensing signal that inhibits sporulation in Bacillus velezensis SQR9 by interacting with RapC and ComA, revealing a population-level regulatory mechanism.

The paper shows that environmental variability affects plant invasion indirectly through changes in soil microbial communities, particularly fungal pathogen diversity.