Y. Liu

The paper describes the purification of a viral reference database (EVRD) by removing contaminating sequences, improving accuracy and efficiency in viromic analysis.

This paper identifies a small-molecule antagonist targeting the Tudor domain of SMN, disrupting its interaction with RNAP II and mimicking SMN depletion effects.

This study designs a de novo regulation system using TFs and CREs to alter plant secondary metabolism, showing reduced tobacco alkaloids and nitrosamines in engineered plants.

This paper develops a BSMV-mediated gene editing system for wheat to improve FHB resistance by editing the Fhb1 gene without requiring transformation.

The paper determines the structure of an IgG-Fc hexamer using cryo-EM, revealing a mutual lock-and-key interaction mode between Fc domains.

This study shows that common plant species, including both native and alien types, benefit more from artificial light at night than rare species, potentially increasing biodiversity loss and alien plant invasion risks.

This paper develops a chimpanzee adenovirus-based vaccine against the SARS-CoV-2 Delta variant and shows it induces strong immunity and protects mice from challenge.

This paper develops temperature-sensitive nanothermometry probes to measure spatiotemporal thermodynamics of lysosomes and mitochondria in living cells, revealing distinct thermal responses to metabolic perturbations.

This study identifies leukemia-intrinsic resistance mechanisms to CAR-T therapy through in vivo CRISPR screening in a murine B-ALL model, revealing IFNγ/JAK/STAT and antigen processing pathways as key mediators.

This paper describes a live-attenuated SARS-CoV-2 vaccine candidate with deleted ORFs that shows reduced replication and attenuation in animal models, and reports its protective efficacy against wild-type virus challenge.

This study characterizes the HERV-K (HML-8) group in the human genome, identifying 40 proviruses and 5 solo LTR elements and determining their integration time and genomic distribution.

This study identifies near-native RNA-ligand poses by analyzing unbinding profiles from molecular dynamics simulations and using a regression model to discriminate native-like structures from decoys.

The paper clarifies two strain rate calculation methods for TBI modeling and shows scheme-dependent results in experimental and FE model data.

This study evaluates the effect of compound Tinglizi Decoction on the non-classical pyroptosis pathway in rats with COPD-related pulmonary hypertension, showing reduced caspase-11, GSDMD, and IL-6 levels.

This study examines how chronic intermittent hypoxia and chronic sleep fragmentation affect gut microbiota, serum metabolites, and tissue morphology in mice, revealing their impact on lipid metabolism.

This study engineers bispecific antibodies against SARS-CoV-2, showing that one design outperforms a cocktail in neutralizing activity and breadth against variants.

The paper develops AI-powered IoT sensors for tracking mouse behaviors with 76.23% accuracy, addressing imbalanced data through sampling and feature selection techniques.

This paper improves robot-assisted TMS by implementing inside-out tracking and projection mapping for better coil placement accuracy.

The paper identifies the X chromosome of the Asian citrus psyllid and compares transcription and DNA methylation between male and female adults, finding sex-specific patterns and no direct link between methylation and gene expression.

This study identifies alveolar macrophage reprogramming by ECP that reduces TGF-β bioavailability and prevents BOS by inhibiting CCR2+ monocyte-driven inflammation.

This study reports the structure of the MCM8/9 helicase complex using cryo-EM, revealing its DNA unwinding mechanism through conformational changes and rotary motions.

This study shows that the LPS-TLR4 pathway promotes NETs formation in AACLF, exacerbating liver injury through mechanisms involving gut-derived LPS and neutrophil activity.

This study quantifies how Omicron variant's RBD mutations enhance binding affinity to ACE2 compared to the original SARS-CoV-2 strain.

This paper identifies a broadly neutralizing antibody, STI-9167, effective against SARS-CoV-2 variants including Omicron and Omicron + R346K, and describes its development for clinical trials.

This study identifies mTOR as a key determinant of chemosensitivity, showing that its inhibition promotes drug-tolerant senescence in cancer cells.

This paper introduces multi-target gRNAs (mgRNAs) to enable high-throughput CRISPR screening, revealing insights into Cas9 dynamics, DNA damage responses, and chromatin changes at endogenous sites.

The paper maps synaptic inputs and outputs of paraventricular oxytocin and vasopressin neurons in mice, revealing sex-conserved inputs and sex-differentiated outputs.

This study develops an aging clock based on blood transcriptome data to assess aging rates and evaluate rejuvenation treatments like NMN and Metformin.

This paper introduces NestedBD, a Bayesian method for inferring phylogenetic trees from single-cell DNA copy number data under a birth-death model, showing improved accuracy over existing methods.