Y. Yang

The paper investigates the genetic basis of rumen evolution by comparing transcriptomes and genomic data across ruminants, camels, and cetaceans, identifying key genetic innovations.

This paper shows PCNA activates the MutLγ endonuclease to promote meiotic crossing over by facilitating strand-specific cleavage of Holliday junctions.

This study tracks the decline of mcr-1 prevalence and genetic changes in mcr-1-positive Escherichia coli after China banned colistin use in animal feed.

This paper introduces a DNA-brick assisted centrifugation method to sort liposomes by size, enabling the study of membrane curvature effects on protein activity.

This study reviews scientific research on farmers' roles in agricultural adaptation to climate change from 2008-2017, finding limited global representation and methodological diversity.

This paper identifies YdiU as a Mn2+-dependent UMPylase in Salmonella that modulates chaperone function through UMPylation, enhancing stress resistance.

The paper examines how 3D chromatin structure and DNA methylation change in cancer, showing increased segregation of chromatin domains and methylation differences that correlate with transcriptional changes.

This paper shows that the Drosophila Torr transporter is essential for cuticle barrier function, similar to the human ABCA12 gene's role in skin lipid barriers, causing desiccation and ichthyosis-like phenotypes when dysfunctional.

The paper identifies essential residues in ATP11A for its expression and flippase activity through mutation analysis and functional assays.

This study identifies calpain-2 as a regulator of hypoxia-induced amoeboid reprogramming and metastasis in breast and head and neck cancers.

The paper identifies a novel glymphatic pathway in the optic nerve for clearing amyloid-beta from the vitreous, which is impaired in glaucoma.

This study identifies a new Asgard archaeal phylum, Gerdarchaeota, and shows their role in organic matter degradation in coastal sediments through genomic and transcriptomic analysis.

This study develops a live cell assay using hFUT1 to profile α1-2-fucosides' role in enhancing influenza A virus infection.

This paper identifies SPOCK1 as a promoter of breast cancer progression by interacting with SIX1 and activating the AKT/mTOR pathway, suggesting it as a potential therapeutic target.

This study identifies genes required for natural competence in Synechococcus elongatus and shows that the circadian clock and darkness regulate the process.

This study investigates how temperature and light affect the survival of Plasmodiophora brassicae resting spores in soil, finding that lower temperatures and burial improve survival while UV light reduces viability.

The paper uses flow cytometry and chloroplast genome sequencing to analyze five fine fescue taxa, identifying unique repeat signatures for potential taxon identification markers.

This study uses CRISPR/Cas9-mediated adenine base editors to generate precise, heritable point mutations in two rice genes, resulting in observable phenotypic changes.

This paper introduces a new transcranial magnetic stimulator coil design that improves depth-focality tradeoff and allows adjustable focal spot size for deep brain stimulation.

This paper establishes a novel human HCC patient-derived xenograft model in immunocompetent mice, showing high tumor formation rates and preserved tumor characteristics.

This study shows that endothelial pannexin 1 channels regulate inflammation by controlling intracellular calcium, which in turn affects IL-1β production and release.

This study shows that Cas9 uses biased one-dimensional diffusion along dsDNA to efficiently locate its target, with diffusion length quantified at 27 bp.

This study identifies PeGATA transcription factors in moso bamboo and shows they regulate shoot growth and rhizome development via GA signaling pathway.

This study shows cediranib inhibits Mycobacterium tuberculosis ClpP1P2 by targeting its equatorial handle domain, revealing conformational changes critical for its function and suggesting a strategy for species-specific inhibitors.

This study shows HIV-1 Nef interacts with LMP7 to reduce immunoproteasome formation and MHC-I antigen presentation, aiding viral immune evasion.

This study investigates how AMPK activity and energy metabolism change in yak muscle during postmortem aging using AICAR and STO-609.

This study identifies O-GlcNAc transferase as a suppressor of hepatocyte necroptosis and liver fibrosis, using both human and mouse models.

This study identifies E-cadherin's role in suppressing sarcoma growth through both signaling (inhibiting p-CREB and TBX2) and mechanical (enhancing cell-cell adhesion) mechanisms.

This meta-analysis evaluates immunosuppressive treatment in IgA nephropathy, finding reduced proteinuria and ESRD risk but increased adverse effects.

This paper introduces a time-resolved digital immunoassay using plasmonic imaging to rapidly and sensitively quantify procalcitonin with a low limit of detection and wide dynamic range.