Z. Zhang

This study shows E. coli upregulates motility genes at slow growth to maintain flagella number and motility, while larger cell size at fast growth optimizes resource allocation.

This paper introduces a noninvasive optical coherence elastography method to profile cell and tissue mechanical properties using ambient vibrations, validated in silico and in vitro.

This study identifies three ultrapotent SARS-CoV-2 neutralizing antibodies effective against B.1.351 variants, showing synergistic effects and protective efficacy in mice.

This study compares gut microbiota composition between officials in a stable environment and train drivers in a dynamic environment, finding differences in diversity and functional predictions.

This study assesses mangrove vulnerability to coastal anthropogenic disturbances using a spatial framework in mainland China, finding aquaculture as the primary threat.

The paper examines the relationship between mangrove forest fragmentation and salt marsh invasion magnitude across a climatic gradient in southeast China.

The paper analyzes the genome of the estuarine oyster to show how climate history and physical forces shape genomic diversity and adaptive plasticity through gene expansion and regulatory selection.

This study identifies novel SARS-CoV-2 receptors through a CRISPR activation screen, revealing LDLRAD3, TMEM30A, and CLEC4G as functional receptors independent of ACE2.

This study identifies FFPE processing errors in oncology panel sequencing by analyzing variants from technical artifacts in FFPE samples with varying fixation times and block positions.

The paper shows that phagosome cargo degradation is kinetically coupled to their intracellular motility, not stochastic.

The paper presents the cryo-EM structure of Drosophila GNPTAB, revealing its catalytic domain and functional residues, and shows dimer interface importance for human GNPTAB activity.

This paper develops a method to create 3D vascularized tissues using bioprinting and surgical anastomosis, showing improved viability and functionality in liver-like constructs.

The paper constructs phylogenetic trees using 8-mer motif sets from genome sequences, finding that CG and TA independent selection patterns reflect different evolutionary states in primates and insects.

This study identifies critical residues for SARS-CoV-2 spike protein binding to ACE2 using machine learning and free energy calculations, showing how specific mutations affect binding affinity.

The paper investigates whether amotosalen, a psoralen used in pathogen inactivation, is a substrate for bacterial multidrug efflux pumps, finding it is pumped out by RND systems in E. coli and Acinetobacter baumannii, potentially reducing its inactivation efficacy against multidrug-resistant pathogens.

This study evaluates antibody resistance and ACE2 usage in SARS-CoV-2 variants, finding SA501Y.V2 shows the highest resistance and expanded host range.

This study compares Brachypodium and Arabidopsis embryo development, finding conserved and divergent transcriptional programs with widespread heterochronic gene expression.

This study presents cryo-EM structures of human ABCA4 in different states, revealing substrate recognition and translocation mechanisms.

This study identifies NAC18.1 as a key gene controlling apple firmness and ripening, showing its functional similarity to the tomato ripening regulator NOR.

This study investigates how PTMs in Nt17 of mutant Httex1 affect aggregation, showing that oxM8 delays aggregation and that combinations with AcK6 inhibit fibrillization, with structural insights from spectroscopy and simulations.

The paper assembles a chromosome-scale, allele-aware autotetraploid genome of alfalfa cultivar Zhongmu-4 and identifies 101 SNPs associated with 27 agronomic traits using GWAS.

This study investigates how the loss of staging habitats affects migration strategies and population dynamics in migratory birds through phenotypic plasticity.

This study develops a selective DYRK2 inhibitor, C17, and identifies novel targets like 4E-BP1 and STIM1, revealing DYRK2's role in protein synthesis and calcium entry.

This study shows R13, a TrkB agonist, improves mitochondrial function and reduces AD-related pathology in 5xFAD mice by enhancing biogenesis and metabolism.

This study develops self-assembling SARS-CoV-2 nanoparticle vaccines that induce protective immunity in mice through subcutaneous and oral administration.

This study analyzes the evolutionary patterns of ACE2 binding affinity to SARS-CoV-2 spike protein across 247 vertebrates and identifies key amino acid mutations driving affinity divergence.

This study evaluates the efficacy of host-directed therapies against the B.1.1.7 SARS-CoV-2 variant and finds similar antiviral activity compared to early-lineage SARS-CoV-2.