Z. Zhang

This study shows that Celastrol reduces colitis by modulating gut microbiota, improving immune balance, and increasing metabolites like pyruvate and adenosine.

This study shows that CD147 antibody inhibits SARS-CoV-2 infection and cytokine storm in variants by blocking viral entry and reducing inflammatory responses.

This study shows that defective endosome-TGN retrograde transport enhances NLRP3 inflammasome activation in macrophages, leading to increased inflammation and susceptibility to sepsis.

The paper identifies CDC20 missense variants linked to familial cancer, showing they impair SAC binding and promote mitotic slippage.

This study identifies SNP markers associated with salt tolerance traits in upland cotton through genome-wide association analysis.

This study identifies on-target point mutations caused by CRISPR-Cas9 in yeast, showing sequence dependence and involvement of NHEJ components.

This study investigates how kinesin binding induces directional asymmetry in microtubule structure through long-range allosteric effects, explaining the directionality of kinesin stepping.

This study identifies two potent monoclonal antibodies against the B.1.351 variant and shows their efficacy against other variants, suggesting their use as an antibody cocktail.

This study identifies CaMYB101 as an anthocyanin biosynthesis repressor in pepper through genome-wide R2R3-MYB analysis and virus-induced gene silencing.

This study examines correlations between SNPs in 13 language genes and culture/education parameters across 26 countries using PCA.

This study identifies STK11IP as a lysosome-specific mTORC1 substrate that regulates lysosomal acidification and autophagy, with implications for therapeutic targeting of autophagy-related diseases.

The paper tests how combined nutrient and light availability affect alien plant competitiveness and finds that multiple resources increase alien plant dominance over natives.

This study presents a chromosome-scale spinach reference genome and resequences 305 accessions to explore evolution, domestication, and genetic basis of agronomic traits.

The paper identifies MOV10 as a new m6A-reader that facilitates mRNA decay via m6A to regulate the WNT/β-CATENIN pathway and maintain mouse embryonic stem cell state.

This study examines how soil quality changes after forest conversion to vegetable cropland and tea plantations, showing contrasting effects on microbial community structure and functions.

The paper reports the discovery of a neutralizing nanobody, VHH60, effective against SARS-CoV-2 and its variants, with high potency and protective efficacy in mice.

This paper introduces EEG-AVE, a model that combines EEG signals with audio-visual data to improve cross-individual affective detection performance.

This study identifies unique hematopoietic features in naked mole-rats, including myeloid bias and quiescent stem cells, linked to their exceptional longevity.

This study shows that naked mole-rats lack thymic involution until midlife and have ectopic cervical thymi with distinct T cell composition compared to mice.

This study shows GC-derived exosomes induce EMT in peritoneal mesothelial cells via TGF-β1/Smads pathway, enhancing GC cell migration and adhesion.

This study shows SAFA interacts with antiviral RNAs to open chromatin and enhance immune gene expression during viral infection.

This study shows TMPRSS2 is a tumor suppressor in lung adenocarcinoma, with its downregulation linked to enhanced antitumor immunity and better response to immunotherapy.

This study shows ARID1A loss activates HERVH, which promotes tumor growth by modulating BRD4-dependent transcription in colorectal cancer.

The paper characterizes human pituitary stem cells using single nucleus RNA-seq and ATAC-seq, revealing distinct cell types, regulatory mechanisms, and age-related differences.

The paper examines genetic and clonal diversity in Leymus chinensis patches, finding strong genetic structure and clonal reproduction within patches.

This paper introduces GraphITE, a deep learning pipeline that transforms multiplex immunofluorescence data into graph embeddings for exploratory analysis of tumor microenvironment patterns.

The paper shows that liver generates NADPH for lipogenesis through serine catabolism, distinct from adipose which uses glucose and the pentose phosphate pathway.

This study examines how TGF-β affects glycosylation patterns in pancreatic cancer cells, identifying N-glycome changes linked to SOX4 expression and SMAD4 deficiency.

This study develops an IFN-armed RBD dimer vaccine that induces strong neutralizing antibodies and T cell responses, offering complete protection against SARS-CoV-2 in rhesus macaques with a single dose.