Z. Zhang

The paper identifies HLA-A2 restricted T cell epitopes in SARS-CoV-2 spike protein and finds that variations in these epitopes may reduce T cell activation and contribute to immune escape.

This study shows that adiponectin improves healthspan and lifespan by enhancing insulin sensitivity and reducing age-related metabolic and inflammatory disorders in mice.

This study examines how positive and negative emotions affect false memory using EEG, finding higher false memory rates and distinct brain activation patterns in the positive emotion group.

This study shows IRGM/Irgm1 worsens atherosclerosis by causing macrophage apoptosis via the MAPK pathway, increasing plaque vulnerability and risk of rupture.

This study reports the spontaneous emergence of drug resistance in Cryptosporidium parvum infected calves treated with a methionyl-tRNA synthetase inhibitor, highlighting the potential for anticryptosporidial resistance.

This study characterizes and corrects noise non-uniformity in back-illuminated sCMOS cameras, showing that corrections can improve image quality for microscopy applications.

This study shows that honeybee gut microbiota influences olfactory learning, brain neurotransmitter levels, and metabolism, with parallels to human autism-related gene expression.

The paper introduces an automated algorithm for labelling Neuropixels data using single-channel spike sorting and spatial spike grouping, achieving over 77% accuracy.

This study determines the structure of the Bax core dimer and shows it forms part of the mitochondrial pore wall during apoptosis.

This paper develops a subunit vaccine against SARS-CoV-2 that induces sterilizing immunity in hamsters, with high neutralizing antibody titers and protection against infection and symptoms.

This study shows that honeybee genetics influence gut microbiota composition and strain-level diversity through social transmission, revealing a gut-brain connection.

This study shows that ANXA1sp reduces ischemic kidney injury by increasing SIRT3, which improves mitochondrial function and limits cell death.

This study identifies PCSK9 as a target to enhance CD8+ T cell antitumor activity by modulating LDLR and TCR signaling in the tumor microenvironment.

This study identifies NEK2-EZH2 signaling as critical for glioblastoma tumor core progression and resistance, and presents a novel inhibitor CMP3a that shows therapeutic potential.

This paper develops a kinetic model of DnaA regulation in E. coli to explain how cell size and cell cycle are coordinated, reproducing experimental results and predicting responses to perturbations.

The study analyzes the urinary microbiota of 147 Chinese women, revealing non-sterile urine with distinct bacterial communities and showing similarity to cervical and uterine microbiota rather than vaginal microbiota.

The paper identifies STAT3 as an inhibitor of Myocardin-mediated cardiac hypertrophy by directly binding to Myocardin and suppressing its transcriptional activity.

This study investigates the role of the BMPR-II-SMAD3/MRTF complex in ASMC proliferation and migration in asthma, finding it contributes to airway remodelling.

The paper determines cryo-EM structures of MlaFEDB and reveals its phospholipid transport mechanism, identifying functional residues and providing insights for antimicrobial drug development.

This paper reports a monoclonal antibody, 3E8, that blocks multiple coronaviruses by targeting ACE2, showing broad-spectrum activity against SARS-CoV-2 variants and other coronaviruses.

The paper identifies a CD127-expressing monocyte subset, M127, associated with anti-inflammatory properties in inflammatory diseases and correlates its expansion with milder COVID-19 outcomes.

This study investigates how phosphorothioate substitutions affect RNA structure and dynamics using MD simulations, QM/MM calculations, and NMR experiments on a riboswitch model.

This study identifies the transferrin receptor (TfR) as an additional receptor for SARS-CoV-2 entry, showing that TfR-mediated infection can occur independently of ACE2 and that targeting TfR has anti-viral effects.

The paper shows altruistic mutant cells in Streptomyces coelicolor experience mutational meltdown due to genomic deletions and increased mutation rates, leading to reduced fitness and sterility.

This study identifies a viral protein translation mechanism involving mitochondrial machinery and highlights mitochondria as a target for antiviral drug development.

This study identifies and characterizes 57 B3 superfamily genes in pineapple, revealing their chromosomal distribution, evolutionary relationships, and expression patterns during flower induction.

This study shows that influenza A virus pre-infection increases SARS-CoV-2 infectivity in multiple cell types and worsens lung damage in mice.

This study reports cryo-EM structures of potent SARS-CoV-2 neutralizing antibodies, revealing bivalent binding mechanisms and their correlation with enhanced neutralization and S1 subunit shedding.

This paper describes a strategy to achieve brain-restricted mTOR inhibition using a combination of a brain-permeable inhibitor and a brain-impermeable ligand, while preserving systemic mTOR activity.

This study systematically analyzes peroxiredoxins (PRDXs) across 33 cancer types, examining expression, genetic alterations, methylation, prognosis, pathways, and drug targets, with validation of PRDX6's role in bladder cancer cell proliferation via JAK2-STAT3 pathway.