C. Chen

This study identifies recurrent neoantigens in colorectal cancer using whole exome sequencing data from multiple cohorts, highlighting potential immunotherapy targets.

This study develops a mouse model of glioblastoma (GBM) that replicates its genomic landscape and early stages, enabling research into prevention and treatment strategies.

The paper introduces GLAMS, a method using glycosyltransferase labeling and mass spectrometry to identify sialylation linkages at the glycopeptide level, successfully identifying 1,236 linkage-specific sialoglycopeptides from human serum.

This study examines the relationship between serum kisspeptin levels and male fertility, finding a strong correlation with sperm concentration and a potential threshold to distinguish obstructive from non-obstructive azoospermia.

This paper introduces an accelerated SWATH MS method for protein biomarker discovery in FFPE tissues, showing reduced instrument time and batch effects while maintaining good protein quantification and clinical separation.

This study shows that hepatic JNK deficiency alters bile acid metabolism and promotes liver cancer via PPARα activation in mice on a high-fat diet.

This study compares the gut microbiome of short-term and long-term medical workers to normal controls, finding significant structural changes linked to hospital exposure.

The paper identifies a unique adipocyte population in bone marrow, MERAs, that regulate bone and vessel homeostasis through single-cell transcriptomics in mice.

This study shows that Cas9 uses biased one-dimensional diffusion along dsDNA to efficiently locate its target, with diffusion length quantified at 27 bp.

This study analyzes the vagino-cervical microbiome of 516 women using metagenomic shotgun sequencing to explore how pregnancy, delivery, and contraception influence microbiome composition.

This study investigates the functional divergence of OsFIE1 and OsFIE2 in rice, showing OsFIE1 is involved in late seed development while OsFIE2 is critical for early seed development and cellularization.

This study reports the structure of PCDH15 and its interactions with CDH23, revealing how its ectodomain functions as a gating spring in inner-ear mechanotransduction.

The paper predicts and validates common neoantigens in colorectal cancer that are both presented and immunogenic, identifying potential universal targets for immunotherapy.

The paper shares over 1,000 cryo-ET raw datasets of yeast cells to enable structural and 3-D biological insights.

This study develops a proteomic workflow for FFPE tissues to stratify prostate cancer and DLBCL samples, identifying MPO as a prognostic marker and showing FFPE's utility for biomarker discovery.

This study monitors cytokine dynamics in mouse infection models and evaluates their diagnostic performance for bacterial bloodstream infections.

This study generates triple knockout mice lacking Fut1, Fut2, and Sec1 to deplete H antigen, finding normal development and fertility despite the absence of the antigen.

This study extends the in vivo haploid induction system from diploid maize to hexaploid wheat by knocking out homologous genes, achieving 2%-3% haploid induction with 30%-60% seed setting rate.

This study compares the mechanisms of three FDA-approved CDK4/6 inhibitors and finds significant differences in their transcriptional, proteomic, and cellular effects, suggesting potential for differential clinical use.

The paper identifies new MmpL3 inhibitors through screens and analyzes resistance mutations to define clades of inhibitors and mutants with differential resistance.

This study evaluates genomic selection effectiveness for winter wheat improvement by assessing prediction accuracy and response to selection across different environmental conditions.

This study identifies and analyzes DNA methyltransferase genes in cotton, showing their functional diversity and stress-specific expression patterns.

This study finds that TP53 mutations in breast cancer increase immunogenic activity, suggesting they could be a biomarker for immunotherapy response.

The paper analyzes ascitic microbiota composition in cirrhotic patients and finds two microbial clusters associated with different clinical outcomes, particularly higher short-term mortality in one cluster.

The paper identifies a nuclear localization sequence in Arabidopsis PARP2 that mediates its import via importin-α and the importin-β pathway.

This study evaluates a novel antibiotic-free gas plasma-activated catheter lock solution, showing it effectively eradicates biofilm microbes and is less toxic to human cells than a standard solution.

The paper studies the yeast chromosome-segregation system using electron cryotomography and perturbations, revealing the structure and dynamics of kinetochore-microtubule interactions.

The paper identifies a novel mechanism where the cytokine receptor Dome interacts with Eb1 to regulate spindle orientation in Drosophila GSCs, linking cell polarity to fate without involving the JAK-STAT pathway.

The paper uses cryo-ET to study nucleosome organization in fission yeast mitotic chromosomes, revealing cluster and megacomplex structures and explaining gene expression patterns during mitosis.

This study uses single molecule FRET to show Cas9 undergoes conformational changes and long-range allosteric communication that regulate DNA cleavage, identifying key residues for improving CRISPR/Cas9 specificity.