C. Jia

Avian-specific Salmonella transition to endemicity is accompanied by localized resistome and mobilome interaction

This study examines the evolution of the resistome in Salmonella Gallinarum during its transition to endemicity, revealing localized mobilome-driven resistance profiles.

The m6A Reader ECT1 Mediates Seed Germination via the DAG2-ECT1-PHYB Regulatory Cascade in Arabidopsis

This study identifies ECT1 as an m6A reader protein that promotes seed germination in Arabidopsis through a DAG2-ECT1-PHYB regulatory cascade involving transcriptional and post-transcriptional control.

SlSAURs, targeted by SlSTOP1, inhibit SlPP2C.Ds to modulate H+-ATPase and tomato root elongation under aluminum stress

This study identifies SlSAURs as regulators of root elongation under aluminum stress by interacting with SlPP2C.Ds to modulate H+-ATPase activity.

Geometry theory of distribution shapes for autoregulatory gene circuits

This study mathematically characterizes the phase diagram of protein distribution shapes in autoregulatory gene circuits, identifying three steady-state shapes and their parameter regions.

The discovery of antimicrobial peptides from the gut microbiome of cockroach Blattella germanica using deep learning pipeline

The paper develops a deep learning pipeline to identify antimicrobial peptides from the gut microbiome of Blattella germanica, finding two AMPs with low toxicity and antimicrobial activity.

Deep learning reveals the complex genetic architecture of a highly polymorphic sexual trait

This study uses deep learning to analyze the genetic basis of male guppy color variation, revealing a polygenic and genome-wide architecture with contributions from neural crest cell migration loci and gene duplicates across sex chromosomes.

The super-pangenome of Populus unveil genomic facets for adaptation and diversification in widespread forest trees

The paper constructs a super-pangenome of 19 Populus species to explore genomic factors driving adaptation and diversification in forest trees.

What can we learn when fitting a simple telegraph model to a complex gene expression model?

The paper fits a simple telegraph model to complex gene expression models to infer effective parameters and reveal underlying regulatory mechanisms using single-cell data from E. coli and mammalian cells.

Brassinosteroids signaling component SlBZR1 promotes fruit ripening in tomato

This study shows that brassinosteroids promote tomato fruit ripening by enhancing ethylene production and carotenoid accumulation through the SlBZR1 transcription factor.

Genomic insights into present local adaptation and future climate change vulnerability of a keystone forest tree species in East Asian

This study identifies climate-associated genetic variants in Populus koreana and predicts its future climate change vulnerability using genomic and environmental data.

Developing High-Affinity Decoy Receptor Optimized for Multiple Myeloma and Diffuse Large B Cell Lymphoma Treatment

This paper develops an engineered sBCMA-Fc fusion protein with enhanced binding affinity to APRIL and BAFF, showing improved antitumor activity against multiple myeloma and diffuse large B cell lymphoma in preclinical models.

Multiomics Interrogation into HBV (Hepatitis B Virus)-Host Interaction Reveals Novel Coding potential in Human Genome, and Identifies Canonical and Non-canonical Proteins as Host Restriction Factors against HBV

Mechanistic insights into the success of xenobiotic degraders resolved from metagenomes of microbial enrichment cultures

The paper analyzes metagenomic data from microbial communities to identify strategies underlying xenobiotic degradation and their ecological interactions.

Brassinosteroid signaling component SlBES1 promotes tomato fruit softening through transcriptional repression of PMEU1

This study identifies SlBES1 as a regulator of tomato fruit softening by repressing PMEU1, leading to firmer fruits with extended shelf life without affecting visual or nutritional quality.

Adsorption mechanism of bacteria onto a Na-montmorillonite surface with organic and inorganic calcium

This study compares the adsorption of bacteria onto Na-montmorillonite using organic and inorganic calcium sources, finding organic calcium forms denser aggregates and is more environmentally friendly.

Mechanistic insights into NAD synthase NMNAT chaperoning phosphorylated Tau from pathological aggregation

This study identifies NMNAT as a chaperone that prevents phosphorylated Tau aggregation in vitro and reduces pathology in a fly model.