H. Yu

SeedExtractor is an open-source GUI tool for rapid and accurate seed size and color measurement across plant species, validated on rice with genome-wide association analysis.

The paper examines how wild emmer introgressions affect root-to-shoot growth dynamics under water stress in wheat, identifying a line with high plasticity and candidate genes for stress adaptation.

This study shows that loss of Aldob activates Akt, promoting hepatocellular carcinoma by destabilizing the Aldob/Akt/PP2A complex, and identifies SMAP as a potential therapeutic agent.

This study identifies the TRNVF motif as responsible for PI5P4Kβ's GTP binding and extended specificity to ITP and XTP, showing how its GTP preference allows it to function as a GTP sensor despite low cellular concentrations of ITP and XTP.

This study infects hACE2 transgenic mice with SARS-CoV-2 and observes pathogenic effects, confirming Koch's postulates and establishing a model for vaccine and therapeutic development.

This study creates a single-cell transcriptome atlas of a non-human primate to explore SARS-CoV-2 targets and immune responses, identifying potential therapeutic targets and mechanisms linking IL6 to viral entry.

The paper shows acetylation of TDP-43 drives its phase separation into intranuclear spherical annuli with liquid properties, regulated by HSP70 chaperone activity and proteasome function.

The paper develops CAR-expressing iPSC-derived macrophage cells with antigen-dependent anti-cancer functions effective against both liquid and solid tumors.

This study shows that rhesus macaques infected with SARS-CoV-2 are protected from reinfection during early recovery, likely due to enhanced neutralizing antibodies.

This study shows that SARS-CoV-2 can cause mild COVID-19 in rhesus macaques through conjunctival inoculation, with distinct viral dispersion patterns compared to intratracheal inoculation.

This study shows that NE-low SCLC tumors have more immune cell infiltration and higher expression of IDO and PVR compared to NE-high tumors, suggesting these as potential immunotherapy targets.

The paper investigates the origin and evolution of A-to-I RNA editing in metazoans, finding it emerged in the common ancestor and is nonadaptive in most regions except for specific taxa.

The paper introduces PI-Plat, a 3D imaging method to estimate rice inflorescence growth dynamics, showing voxel count correlates with seed number and maturation rate.

The paper uses a synthetic system to study maize auxin signaling, showing that the circuit is sensitive and functionally similar to Arabidopsis.

This study shows HIV-1 Vpr suppresses IRF7 and IFN-I expression in pDCs by degrading TET2, thereby enhancing HIV-1 replication.

This study examines the relationship between serum kisspeptin levels and male fertility, finding a strong correlation with sperm concentration and a potential threshold to distinguish obstructive from non-obstructive azoospermia.

This study examines how modified sialic acids in mucus and erythrocytes affect influenza A virus HA and NA functions, finding that these modifications inhibit viral binding and cleavage.

This study identifies determinants of sialoglycan-binding selectivity in Siglec-like adhesins and creates engineered binding proteins for specific glycan recognition.

This paper uses single-cell RNA sequencing to characterize neutrophil heterogeneity and maturation during homeostasis and bacterial infection, revealing distinct subsets and their functional transitions.

This study determines the cryo-EM structure of RyR1 and uses simulations to analyze cation hydration and conduction mechanisms in the receptor.

This paper engineers transketolase to accept novel donor and acceptor substrates, improving catalytic efficiency and stereoselectivity for industrial applications.

This study evaluates immune responses in mice to multi-epitope DNA and protein vaccines against CCHFV, finding that DNA prime-protein boost strategy enhances both cellular and humoral immunity.

The paper presents a comprehensive phosphoproteomic dataset for budding yeast, identifies cell cycle-regulated phosphorylation events, and shows phosphorylation disrupts protein-protein interactions.

This study reveals the Ca2+ permeation mechanism through RyR1 using molecular dynamics simulations, showing a one-at-a-time hydrated ion translocation pattern.

This study identifies mutant p53's role in promoting clonal hematopoiesis by modulating the EZH2-mediated epigenetic pathway.

This study shows that formaldehyde inhibits osteoblast proliferation and migration via the FoxO1 signaling pathway in mouse cells.

This study presents two structures of SETD3 bound to β-actin peptides, revealing sequence-specific recognition and methylation mechanism.

The paper shows that a soybean PBS1 decoy protein with a SMV NIa protease cleavage site triggers cell death and inhibits SMV spread, suggesting decoy engineering can be used in soybean and other crops.