J. Chen

The paper identifies a proliferative exhausted CD8+ T cell cluster in HPV-positive HNSCC that correlates with better patient survival and suggests potential therapeutic implications.

Mitoxantrone synergizes with vancomycin against vancomycin-resistant Enterococcus faecalis by direct antibiotic activity and enhancing host macrophage recruitment and bactericidal activity.

This study shows that CVC1302 in oil formulation enhances Th1 immune responses by targeting antigen and inflammatory monocytes to lymph node inter-follicular regions and promoting IL-12 production by cDC2.

This paper introduces TimedHN, a method that infers oncogenetic graphs and pseudo-time orders from cancer data, outperforming existing methods on synthetic and breast cancer datasets.

The paper identifies a compact, stable dimeric conformation of α-synuclein that may promote dityrosine linkage and is implicated in Parkinson's disease.

The paper generates a transcriptomics dataset of developing durum wheat endosperm to study starch biosynthesis and provides insights into gene expression patterns during grain development.

A protease inhibitor from kumquat enhances freezing tolerance by stabilizing proteins through inhibition of non-specific protease degradation.

This study investigates how PIEZO1 regulates leader cell formation and coordinated migration during keratinocyte wound healing, finding that PIEZO1 inhibits leader cell formation and disrupts coordinated directionality.

This study develops a high-affinity, specific TCR targeting NY-ESO-1 through engineering and screening, showing efficacy in tumor models and approval for clinical trials.

This paper describes a system for generating and assessing e-cigarette aerosol exposure in animals, showing higher nicotine concentrations in arterial blood compared to venous blood.

This study identifies PCLAF-DREAM's role in alveolar cell plasticity during lung regeneration and shows a drug candidate can pharmacologically target this process to prevent fibrosis.

This study identifies LINC01184 as a tumor-promotive factor in hepatocellular carcinoma, showing its overexpression correlates with poor patient outcomes and its role in promoting cell proliferation and migration.

This study identifies YTHDF1 as an oncogenic m6A reader promoting AML by enhancing oncogenic translation and shows tegaserod inhibits its function.

This study identifies MRC's organ-specific roles in regulating starch granule initiation in wheat leaves and endosperm, showing it promotes leaf granules but delays endosperm B-type granule initiation.

This study shows that MFN2 deficiency leads to increased cytosolic Ca2+ and overactivation of RhoA and non-muscle myosin II, causing atypical peripheral actin band formation in mouse embryonic fibroblasts.

This study evaluates an intranasal influenza-based vaccine against SARS-CoV-2 variants, showing it reduces inflammatory response and tissue damage through local immunity.

The paper combines single cell and spatial transcriptomics to map spatial organization and functional interactions in colorectal cancer across species.

This study uses multiomics to show that silk fibroin and sericin enhance mesenchymal stem cell paracrine activity and tissue regeneration through distinct pathways.

The paper traces the evolutionary origin of brackish archaea, showing gene rearrangements enabled their adaptation to coastal environments after the Cryogenian Snowball Earth.

A T cell vaccine based on conserved epitopes protects HLA transgenic mice from SARS-CoV-2 Beta variant mortality without inducing neutralizing antibodies.

This study identifies LINC02428 as a liver-specific lncRNA that suppresses hepatocellular carcinoma progression by inhibiting cell proliferation, migration, and inducing apoptosis.

The paper uses human pluripotent stem cell-derived lung and heart models to identify antiviral compounds with distinct profiles, highlighting the need for multi-organ testing in SARS-CoV-2 treatment.

This study identifies two brain atrophy dimensions in Alzheimer's disease using Surreal-GAN and links them to genetic and clinical factors, revealing distinct pathological mechanisms.

The paper shows cancer cells in resistant tumors promote immune-suppressive macrophages, reducing T-cell activation, and suggests balancing cell cycle inhibition with immune activation for better therapy.

This study defines an interconverting ensemble of ePEC states using cryo-EM and biochemical analysis, showing that ePECs occupy pre- or half-translocated states without always swiveling.

The paper identifies a new family of phage-inducible chromosomal islands that produce small capsids using phage tails and spread without harming their helper phages.

This study shows that initial niche conditions determine the aging speed and regenerative activity of quiescent fission yeast cells, with regenerative activity declining linearly before survivability.

This study shows that WDFY4 deficiency in NOD mice prevents autoimmune diabetes by blocking CD8 T cell priming, while preserving CD4 T cell activation and islet infiltration.

The paper identifies enhancer-based biomarkers of resistance to anti-PD-1 therapy in melanoma and suggests enhancer blockade combined with ICB as a potential strategy to improve treatment responses.

The paper identifies RALF33-FER as an early signaling module between wounding and root regeneration, interacting with TPL/TPRs to regulate regeneration-related genes.