J. Chen

This paper characterizes mineral ellipsoid packing at the bone-implant interface of Ti6Al4V porous implants using microscopy techniques and identifies orientation shifts that may contribute to bone strengthening.

The paper introduces graph-pMHC, a graph neural network for predicting MHC Class II peptide presentation and improves antibody immunogenicity risk prediction.

The paper shows that CpG ODNs interact with mitochondrial VDAC1 to induce antimicrobial ROS in lung epithelial cells, offering a new therapeutic strategy for pneumonia without antibiotics.

The paper identifies the T813S mutation in the S2 subunit of SARS-CoV Spike protein enhances fusogenicity by improving TMPRSS2 cleavage, increasing viral replication.

This study identifies VRAC as an ATP-releasing channel in microglia contributing to neuropathic pain and shows dicumarol inhibits it, reducing pain behaviors in mice.

This paper develops a collagen-based bioink for DLP 3D printing, achieving tunable mechanical properties and high-resolution structures suitable for biomedical applications.

This study compares osseointegration of functionally-graded and uniform porous Ti6Al4V implants in rabbit tibiae, finding that smaller pores promote better bone volume and implant contact.

The paper identifies an extended gradient of Th17 activity in human CCR6+ Th cells, showing both stable phenotypes and plasticity under different activation conditions.

This study evaluates six nonantibiotic growth promoters in broilers, finding they improve nutrient utilization, intestinal morphology, and microbial composition compared to control and enramycin.

This study removes residual undifferentiated iPSCs from spinal-cord progenitor cells using size-based microfluidic separation, reducing OCT4-positive cells without affecting viability.

The paper investigates a spatially structured cyanobacterial community, finding that niche formation and metabolic interactions maintain stable diversity over time.

The paper identifies eEF2 as a prognostic biomarker for dense connective tissue repair outcomes and shows it regulates cellular processes to improve healing.

The paper analyzes NRE sequences in RLKs and RLCKs from 528 plants to uncover structural-functional relationships and phosphorylation motifs, revealing their role in kinase regulation.

The paper reports the cryo-EM structure of the Mce1 fatty acid import machine from Mycobacterium smegmatis, revealing its assembly and a previously unknown subunit, LucB.

HLApollo improves MHC-I peptide presentation prediction with a transformer model, showing better performance than existing methods and offering pan-allelic generalization.

The paper characterizes a novel botybirnavirus, DtBRV1, found in Didymella theifolia, which infects tea plants, and identifies a unique dsRNA unit with distinct molecular features.

The paper introduces cDNA display proteolysis to measure protein folding stability for thousands of protein domains, revealing environmental factors, thermodynamic couplings, and evolutionary divergence in amino acid usage.

This study develops a mathematical model to explain how Myxococcus xanthus uses mechanosensing during gliding motility to coordinate cell reversal frequency and multicellular pattern formation.

This study identifies line-specific barriers to reprogramming transformed cells and shows that MEK inhibition can overcome some of these barriers by modulating the epigenetic state.

This paper shows that enhancer capture-divergence (ECD) is a significant evolutionary mechanism for asymmetric, distally duplicated genes, using Drosophila HP6/Umbrea as an example.

This study optimizes protein extraction methods for human sperm and investigates antibiotic effects on sperm proteome, finding increased concentration and malformed sperm with altered proteome expression.

The paper analyzes the holocentromere organization in Chionographis japonica, revealing that its holocentromeres consist of few, large satellite arrays and differ from other holocentric species.

This study identifies OsCAX2 as a key gene for cadmium tolerance and accumulation in rice by promoting vacuolar sequestration, reducing grain cadmium levels by over 70%.

The paper describes how two species of flying squirrels in Hainan Island use a mortise-tenon structure to securely cache nuts on twigs to deter predation and ensure food supply.

The paper introduces HDStIM, an unsupervised method to analyze single-cell stimulation responses, revealing increased tonic activation in immune cells during puberty.

This study uses cryo-EM to reveal a new binding site for NaV1.7 inhibitors, enabling the design of hybrid inhibitors with improved selectivity and properties.

The paper shows that sterile tissue injury causes B cell death in Peyers patches via neutrophil-released toxic DNA, leading to tissue shrinkage and reduced secretory IgA.

This paper introduces ConstrastivePose, a contrastive learning method for self-supervised feature engineering in pose estimation and behavioral classification of interacting animals, showing improved performance over handcrafted features.

This study analyzes single-cell transcriptomes of gastroenteropancreatic neuroendocrine tumors to identify lineage diversity and immunosuppressive programs in tumor and immune cells.