J. Chen

This study shows that DeltaNp63 is essential for maintaining epidermal homeostasis, stemness, and inflammation suppression in adult skin, with its loss causing psoriasis-like inflammation and impaired wound healing.

The study identifies RBP45d as a key regulator of 5' splice site selection in Arabidopsis by binding to intronic U-rich elements and interacting with PRP39a.

The paper identifies EaF82, a RALF-like peptide, which delays tapetum degeneration in Arabidopsis by reducing ATP levels through AKIN10 interaction, impairing pollen development.

This study identifies spike-specific CXCR3+ TFH cells as key drivers of long-term antibody responses in SARS-CoV-2 infection and vaccination.

This study identifies and functionally predicts sugar beet circRNAs involved in drought responses using deep sequencing and network analysis.

This study identifies EFNA4 amplification as a driver of lung adenocarcinoma lymph node metastasis through genomic analysis and functional experiments.

This paper develops equine polyclonal antibodies that broadly neutralize major SARS-CoV-2 variants, showing high efficacy in vitro and ex vivo with low cost and potential for large-scale production.

This study identifies a unique leaf-root coordination mechanism in mangroves driven by leaf water storage tissues, distinct from non-mangrove plants.

This study identifies a novel subtype of HRD in HBVHCC caused by CDW19S perturbation and shows it can be targeted therapeutically.

This study uses molecular dynamics to show that ShHTL7 has enhanced MAX2 binding due to its T2-T3 helix structure, contributing to its higher signaling activity compared to other strigolactone receptors.

The paper identifies genetic and regulatory mechanisms underlying heterosis in the rice hybrid Y900 by analyzing genome and transcriptome data from its parental lines.

This study shows that covalent butenolide modification of histidine enhances strigolactone receptor activation, with greater effect in the parasitic ShHTL7 receptor.

This study develops methods to culture planarian neoblasts and deliver exogenous mRNAs, demonstrating retained pluripotency and improved yield.

This study computationally predicts T cell epitopes in RSV proteins and finds divergent epitope patterns between RSV-A and RSV-B strains, suggesting vaccine updates may be needed for RSV-B.

This study shows GT0918 reduces cytokine release and inflammation in COVID-19 by inhibiting NF-κB and activating NRF2, suggesting its potential for treating both mild and severe cases.

The paper shows that the IFNA pathway promotes aggressive KRASG12D-mutant pancreatic ductal adenocarcinomas through IFNAR1/STAT3 activation and identifies IFNAR1 inhibition as a potential therapeutic strategy.

This study generates functional posterior spinal motor neurons from hPSCs-derived neural progenitor cells, demonstrating efficient differentiation and functional maturity.

This study tests an NLRP3 agonist added to PD-1/VEGFR inhibitors in murine HCC models with liver damage, finding it feasible but ineffective in improving tumor outcomes.

This study identifies the optimal scanning speed and fiber-to-stone distance for maximizing dusting efficiency during Holmium: YAG laser lithotripsy by comparing photothermal ablation and cavitation effects.

This study shows ESCO2 remains stable during DNA replication in Xenopus egg extracts and transgenic somatic cells, even under DNA damage or increased replication conditions.

This study combines transcriptome and metabolome analysis to identify molecular responses of Desmodesmus sp. to sewage treatment, revealing key pathways and metabolite changes.

This paper identifies sex-specific niche signaling differences in hematopoietic regeneration following stem cell transplantation and shows exogenous sex hormones regulate hematopoietic stem and progenitor cells.

The paper identifies pre-treatment immune signatures associated with immune-related adverse events (irAEs) in thymic cancer patients receiving checkpoint inhibitors using CITE-seq.

This study investigates the adhesion of SARS-CoV-2 S proteins from different variants to human ACE2 using single-molecule and single-cell force spectroscopy, finding Delta variant has the highest binding affinity.

This study uses cryo-EM to reveal how the SARS-CoV-2 RTC discriminates between natural NTPs and the antiviral remdesivir triphosphate, providing insights for antiviral design.

This study maps epithelial cell states and plasticity in lung adenocarcinoma using single-cell data, identifying KRT8+ alveolar intermediate cells linked to poor survival and tumorigenesis.

This paper introduces a new fluorescent marker, PKMO, enabling 3D live-cell STED nanoscopy of mitochondria with improved photostability and reduced phototoxicity, allowing multiplexed imaging of mitochondrial dynamics and interactions.

The paper investigates HIV-1 spike protein dynamics using cryo-EM and simulations, showing how tilting exposes the MPER to antibody attack and alters membrane fusion.

This study uses QM/MM simulations to investigate the mechanism of strigolactone hydrolysis by DWARF14, finding the acyl substitution pathway is favored and covalent modifications are dynamic.

This study identifies CiS40-11 and its orthologs AtS40-5 and AtS40-6 as regulators of leaf senescence that promote cytokinin synthesis by inhibiting MYB2 expression.