J. Hu

This study identifies structural defects in ZIP4's extracellular domain caused by AE mutations, leading to mistrafficking and loss of zinc uptake.

This study develops a virus-free live-cell visualization system for SARS-CoV-2 entry using a fluorescent spike trimer probe, enabling analysis of neutralizing antibodies and inhibitors.

This study investigates how Parkinson's Disease mutations affect LRRK2 activation and subcellular localization through conformational changes and domain interactions.

This study shows the D614G mutation in SARS-CoV-2 spike protein increases viral infectivity and is more susceptible to elastase cleavage, with minimal impact on neutralizing antibody efficacy.

This study shows that AKAP95 protein condensates regulate splicing and tumorigenesis through their biophysical properties.

This study shows that Bcl6 deletion in Treg cells reduces tumor growth by impairing their suppressive function, and increased Bcl6 expression is linked to poor cancer outcomes.

This study compares the immune landscape of a genetically-engineered murine glioma model to human glioma using single-cell sequencing, finding similar immunosuppressive features but differences in immune cell composition between mouse models and human samples.

This study shows that cancer cells with increased MRTF signaling are more rigid and vulnerable to immune cells, revealing a mechanical aspect of immunosurveillance.

The paper identifies an immunosuppression signature (IMS) and shows that its ratio to an IFN-γ signature better predicts anti-PD-1 therapy response in melanoma than existing biomarkers.

The paper shows that inhibiting the integrin-TGF-β axis enhances NK cell function against glioblastoma stem cells, suggesting it as a therapeutic target.

This study shows rottlerin reduces DSS-induced colitis in mice by enhancing intestinal barrier function through the Epac-2/Rap-1 signaling pathway.

This study shows that HBV infection enhances the hexosamine biosynthesis pathway, leading to O-GlcNAcylation of SAMHD1, which boosts antiviral immunity against HBV and HIV-1.

This study identifies an essential aspartate residue for lanthanide coordination and function in XoxF and ExaF dehydrogenases.

This paper develops and evaluates two novel PET tracers, [18F]fluorophenylglutamine and [18F]fluorobiphenylglutamine, for imaging glutamine metabolism in tumors, showing promising in vitro and in vivo results.

This paper introduces a high-throughput drug screening method called CEBIT that detects biomolecular interactions and enzyme inhibitors by using phase-separated compartments.

The paper reports the complete genome sequence of a novel BPV type 15 strain from a cow in southern Xinjiang and places it phylogenetically within the Xipapillomavirus genus.

This study investigates how substrate structure influences stereoselectivity in MCO-catalyzed oxidative coupling reactions mediated by VdtB and VdtD in the biosynthesis of viriditoxin.

This study identifies the key interaction region and phosphorylation site of EcaICE1 that mediates its interaction with EcaHOS1 in Eucalyptus.

This study identifies the transcription activation domain and interaction region of EcaICE1 with EcaSIZ1 in Eucalyptus camaldulensis, revealing potential SUMOylation pathway similarities to Arabidopsis thaliana.

This study identifies miR476a/RFL as a regulator of adventitious root formation in poplar through mitochondrial homeostasis and auxin pathway modulation.

This study constructs large-scale, morphologically controlled λ-DNA networks using a DC electric field and investigates factors affecting their structure.

The paper develops DPY30-targeting peptides that inhibit blood cancer cell growth by disrupting ASH2L binding and H3K4 methylation.

The paper identifies GATA2 overexpression in early-stage atherosclerotic macrophages as a driver of functional defects linked to atheroma formation.

The paper uses super-resolution imaging to show that chromatin structure decompacts and fragments during early cancer development, even before tumors form, and this change may improve cancer detection and risk assessment.

This study introduces a method to genotype MHC class I and II from rhesus macaque exome sequences with high accuracy, outperforming conventional methods.

The paper identifies a gene cluster responsible for viriditoxin biosynthesis in fungi, elucidates its pathway, and identifies key enzymes involved.

This paper shows that papillomavirus can be transmitted through blood and cause infections in animal models, suggesting blood transfusion as a potential route for HPV infection and cancer in humans.

This study identifies α-tubulin in Laodelphax striatellus as a facilitator of rice stripe virus (RSV) passage through midgut and salivary glands, enhancing horizontal transmission.

This study shows that spotted doves can be infected with SFTSV, with severity depending on viral strain and dose, and suggests they may play a role in virus transmission.

This study shows that vimentin intermediate filaments provide cytoplasmic mechanics that enhance strength, stretchability, resilience, and toughness under severe deformations.