J. Song

This study reveals the structural mechanism by which VcINDY couples sodium and substrate binding through an induced-fit mechanism, showing that sodium binding stabilizes the substrate binding site.

This study shows that homologous or heterologous boosters of inactivated vaccines increase neutralizing antibodies against SARS-CoV-2 Omicron, reducing escape from neutralization.

This paper identifies Myricetin as an allosteric inhibitor of Dengue NS2B-NS3 protease, showing it disrupts the active conformation and locks the inactive one through binding to new and existing allosteric sites.

The paper identifies LRRC15 as an inhibitory receptor that blocks SARS-CoV-2 spike-mediated entry in trans, primarily expressed in fibroblasts and not co-expressed with ACE2.

This study identifies natural killer-like B cells as pathogenic in rheumatoid arthritis by promoting Th17 differentiation and disease severity.

This study identifies TiAP1 from Thinopyrum intermedium as a resistance gene against Blumeria graminis f. sp. tritici, showing it interacts with BgtCDA1 and enhances wheat resistance through immune activation.

This study uses a fluorescent SUMO biosensor to show that prostate cancer cells have higher and reversible cytosolic SUMO enrichment under stress compared to normal cells.

This paper identifies a monoclonal antibody, 2G1, that neutralizes all SARS-CoV-2 variants with high potency and describes its mechanism of action and therapeutic efficacy in animal models.

The paper identifies two distinct pathways for ER-to-LD protein targeting and characterizes the molecular machinery involved.

This study shows that lipocalin 2 promotes inflammatory breast cancer aggressiveness and skin invasion by enhancing proliferation, migration, and metastasis.

This study investigates the cellular localization and cytoskeleton interactions of reflectin proteins, revealing their localization preferences and potential mechanisms for nuclear entry and cytoskeletal binding.

This study shows that liposomal dexamethasone reduces mortality and inflammation in mice infected with A/H1N1 influenza by targeting monocyte/macrophages.

This paper develops a framework for rapid bacterial species identification using 3D quantitative phase imaging and artificial neural networks, achieving 99.9% accuracy with single colony-forming units.

This study characterizes antibiotic resistance gene signatures in extensively drug-resistant Salmonella Typhi isolates from pediatric septicemia patients to inform molecular detection methods and control strategies.

The paper identifies RNA editing of the BOSS gene in tomato that regulates flowering by producing functionally distinct transcripts.

This paper identifies HCQ's specific binding to SARS-CoV-2 N protein to inhibit nucleic acid interaction and LLPS, showing its potential as an anti-SARS-CoV-2 drug effective against variants.

This study identifies BIRG1 as a chloride efflux transporter in rice that regulates grain size and salt tolerance by controlling chloride homeostasis.

This study identifies NAC18.1 as a key gene controlling apple firmness and ripening, showing its functional similarity to the tomato ripening regulator NOR.

This paper constructs and analyzes metabolic models of Drosophila gut microbiota under different nutrient regimes to reveal dynamic metabolic interactions and their impact on host physiology.

This study investigates the stability, ATP-binding, and conformational dynamics of TDP-43 and hnRNPA1 RRM domains in tethered and isolated forms, revealing their aggregation-prone behavior and the inhibitory role of ATP.

The paper shows that MYB31 activation and CBG expression in the pericarp of C. chinense leads to high capsaicinoid accumulation, explaining the extreme pungency of these peppers.

This paper investigates how PDE1 inhibition increases cardiac contractility by enhancing Cav1.2 channel conductance through PKA, with less intracellular calcium rise and arrhythmia compared to beta-ARs or PDE3i.

This study uses directed evolution to identify SH2 domain variants with enhanced binding to phosphotyrosine peptides, revealing differences in cross-reactivity with sulfotyrosine.

This study shows ATP biphasically modulates TDP-43 PLD LLPS by binding arginine residues, altering physicochemical properties and aggregation behavior.

This study identifies KLHL15 as an E3 ubiquitin ligase that degrades doublecortin proteins, regulating dendritic development in neurons.

This study shows NDRG1 expression is an independent predictor of poor survival in inflammatory breast cancer patients.

This study identifies a conserved cavity in flaviviral NS2B-NS3 proteases that Curcumin binds to, allosterically inhibiting the protease by disrupting its active conformation.

This paper develops a fluorescent chemodosimeter to visualize and isolate iron-reducing microorganisms at the single-cell level, demonstrating its effectiveness in identifying active FeRM from complex samples.

The paper identifies lysine isobutyrylation as a new histone modification mark and shows its role in epigenetic regulation and cellular physiology.