J. Wang

The paper identifies mislabeled Drosophila stocks and shows how alignment-free phylogenomic analysis clarifies their true origins.

This study discovers that reversible covalent chemistry enhances PROTAC intracellular accumulation and target engagement, leading to improved efficacy.

This study investigates how urea and KI together denature protein structures through molecular dynamics simulations of TRPZIP4 in mixed solutions.

This study uses molecular dynamics simulations to show trehalose stabilizes protein structure by forming hydrogen bonds and replacing water molecules around the protein.

This study identifies host genetic variants associated with gut microbiome and examines causal relationships between gut microbiome and human complex diseases, revealing shared and distinct microbiome features.

The paper introduces the Kinase Chemogenomic Set (KCGS), a curated collection of 187 selective kinase inhibitors covering 215 human kinases, for use in cell-based screens.

The paper establishes a clinically and genomically annotated nerve sheath tumor biospecimen repository to support research on NF1-related tumors.

The paper introduces a microbial microdroplet culture system (MMC) that enables automated, high-throughput microbial cultivation and adaptive evolution, showing improved growth rates compared to conventional methods.

The paper introduces a genetically encoded 1D 1H-NMR probe for studying conformational changes in large membrane protein complexes, demonstrating its effectiveness with minimal protein and time.

This study describes a method to expand pancreatic islet clusters in vitro using hormones and chemicals, resulting in functional islet-like structures with cell type markers.

This study shows FLASH irradiation reduces intestinal injury while maintaining ovarian cancer treatment efficacy in preclinical models.

The paper analyzes the intestinal stem cell niche by combining bulk RNA sequencing and scRNA-seq to identify a network of cell types and signals involved in ISC regulation.

This study shows cells can sense long-range biomechanical forces through the matrix to initiate distant mechanical communication, enabling coordinated self-assembly.

This study shows that combining MEK and CDK4/6 inhibitors with immune checkpoint inhibitors improves pancreatic cancer treatment by enhancing T-cell infiltration and altering myeloid populations in preclinical models.

This study evaluates moxifloxacin efficacy against Mycobacterium abscessus in a zebrafish model, finding limited in vivo activity despite good in vitro results.

This study shows that copy number profiles are conserved in patient-derived xenografts (PDXs) through engraftment and passaging, indicating minimal impact from the mouse host on tumor evolution.

This study compares genome content and predatory phenotypes between Bdellovibrio sp. NC01 and B. bacteriovorus HD100, revealing differences in prey range and predation efficiency linked to horizontal gene transfer.

The paper introduces PACPIC, a method using phase separation to identify direct and indirect protein-protein interactions in cells by recruitment as a readout.

This paper develops a mechanochemical model to study how cell tension affects migration, showing it inhibits movement under persistent stimuli but can enhance migration under random noise.

This study expresses, purifies, and functionally reconstitutes 19F-labeled cytochrome b5 in peptide nanodiscs to enable NMR studies of its transmembrane domain interactions with CYP2B4.

This study demonstrates that transient expression of Runx1 and Hoxa9 in pluripotent stem cells generates functional T cells capable of immune surveillance and tumor eradication.

The paper presents a large multi-omic cohort of 2,183 adults to identify correlations between gut microbiome features and various health-related factors, validated in an additional cohort.

The paper investigates how peripheral mutations in CYP1A2 affect substrate channel dynamics using computational models, finding that some mutations disrupt water channels and substrate binding.

This study constructs large-scale, morphologically controlled λ-DNA networks using a DC electric field and investigates factors affecting their structure.

This study examines how hearing sensitivity changes with age in red-eared slider turtles, finding frequency-specific developmental patterns and age-related shifts in auditory thresholds.

The paper presents a method combining global peptide docking and accelerated molecular dynamics simulations to improve peptide-protein binding predictions, achieving high-quality models for some cases.

This study examines genomic variation across four Populus species to show that selection and genomic features shape patterns of diversity and divergence during speciation.

The paper assembles over 56,000 metagenome-assembled genomes from oral microbiome samples, revealing new taxa and biomarkers for diseases.

The paper reports a quadruple mutant of hepatitis B virus showing moderate resistance to tenofovir and demonstrates that combination therapy with entecavir and tenofovir effectively suppresses this resistant mutant.

The paper identifies CbuSPL9 and its interacting protein CbuHMGA in Catalpa bungei, showing they form a heterodimer and may regulate flowering development, not transition.