J. Wang

This study identifies small molecule modulators that enhance exosome secretion from mesenchymal stem cells without affecting their functional properties.

This study investigates the role of reactive oxygen species (ROS) in plant cell division and cold stress adaptation, finding that ROS influence cell wall stiffness and regulate division rates in Brassica napus.

This study investigates the competition mechanisms between HIF-1 and CITED2 binding to TAZ1 using structure-based models and simulations.

The paper analyzes 120 SARS-CoV-2 genomes to identify genetic subgroups, recombination events, and a unique spike protein insertion that may enhance infectivity.

This paper develops miR-101a-loaded mesenchymal stem cell extracellular nanovesicles for cardiac repair, showing reduced infarct size and improved cardiac function in a minimally invasive approach.

This study identifies altered B cell subset homeostasis in IgAV patients, with increased plasmablasts and decreased specific memory B cells, correlating with IgA levels.

This paper demonstrates RNA aptamer-based labeling methods for super-resolution imaging of proteins fused to common tags, showing advantages for live cell imaging and quantifying plasma membrane protein trafficking.

The paper shows dietary glucose promotes Plasmodium infection by expanding a gut bacterium that alkalizes mosquito midgut, enhancing parasite development.

This study samples ileocecal microbiome in situ using transendoscopic tubing and finds distinct metatranscriptomes compared to fecal samples, diurnal rhythms in bacterial activity, and metabolomic parallels to gut microbiome changes.

This paper shows epigenetic reprogramming of mesenchymal stem cells into CA-MSCs drives ovarian cancer metastasis through partial MET and WT1/EZH2-mediated mechanisms.

This study shows that intra-BM MSC transfusion restores the BM microenvironment, suppresses leukemia, and reprograms macrophages to reduce tumor burden.

This study reports a randomized trial using intranasal mechanical stimulation to reduce ME symptoms by 30% and identifies immune correlates of improvement, suggesting disease tolerance failure as a potential mechanism.

The paper uses live cell imaging to show that the TPLATE complex is recruited to the plasma membrane as an octameric complex, not sequentially.

The paper uses single-cell RNA sequencing to analyze stomatal lineage cell development in Arabidopsis, identifying new marker genes and transcriptional networks.

The paper analyzes transcriptomic and proteomic data from a new cytoplasmic male sterile cotton line to identify differentially expressed genes and proteins involved in microspore abortion.

The paper quantifies vertebrate biodiversity in Ailaoshan reserve using leech iDNA, showing species richness increases with elevation and distance from the reserve edge.

This study identifies alpha-ketoamides as broad-spectrum inhibitors effective against coronavirus and enterovirus proteases, with compounds showing low-micromolar activity in cell cultures.

This study identifies an insertion sequence in SARS-CoV-2 spike protein that enhances cleavage efficiency and expands tissue tropism beyond the lungs.

This study performs a large-scale RNAi screen in Schistosoma mansoni to identify therapeutic targets, finding genes involved in neuromuscular function, tissue integrity, and parasite survival.

This study identifies PvdS as a regulator of the type I-F CRISPR-Cas system in P. aeruginosa under iron-depleted conditions, enhancing horizontal gene transfer interference.

This paper identifies centromeres in Phytophthora sojae using long-read sequencing and ChIP-seq, revealing transposon-rich, heterochromatic regions distinct from other SAR supergroup organisms.

This study identifies ACE2-expressing cells in the digestive system using single-cell transcriptomes, suggesting the digestive tract as a potential route for 2019-nCov infection.

The paper introduces an efficient long fragment editing technique for scarless genome engineering in E. coli, enabling large-scale DNA insertion and deletion with high success rates.

This study shows PAT2 regulates autophagy in brown adipocytes by promoting vATPase assembly and lysosomal acidification in response to amino acid withdrawal.

This paper introduces a high-throughput drug screening method called CEBIT that detects biomolecular interactions and enzyme inhibitors by using phase-separated compartments.

This study identifies new epigenetic and genetic biomarkers for esophageal cancer using cfDNA and combines SALP-seq with machine learning.

This paper introduces GNEPS, a fluorescent sensor that detects intracellular GTP:GDP ratios in real-time, showing its utility in monitoring metabolic changes across cell types and organelles.

This paper describes an automated peptide mapping protocol using a robotic liquid handling system to improve reproducibility and reduce hands-on time compared to manual methods.

This study shows that RIP1 kinase activity in macrophages drives steatohepatitis by promoting cell death and inflammation, and its inhibition reduces liver injury in NASH models.

This study improves subspecies identification of Mycobacterium abscessus complex using whole genome sequencing by developing a method based on rpoB, erm(41), and rpls genes, achieving 100% accuracy in public and clinical isolates.