J. Yang

This study identifies a novel role of low barrier hydrogen bonds in promoting selective tubulin degradation through small molecule interactions.

This study identifies two non-coding A-to-T mutations at the Kozak site of the N gene as potentially contributing to the transmissibility of Alpha, Delta, and Omicron SARS-CoV-2 variants.

This study analyzes rabies virus variants from ferret badgers in China, identifying four lineages and assessing their pathogenicity and distribution.

This study identifies 12 serum metabolites associated with esophageal squamous cell carcinoma and highlights pipecolic acid as a predictive biomarker for tumorigenesis.

This study shows that ribosomal protein (RP) deficiency affects gene expression through translational and transcriptional changes, with distinct impacts on cell growth, apoptosis, and development.

Analysis of multiple tmk mutants reveals key roles of TMKs in plant development, including organogenesis, leaf size, fertility, and selfing population defects.

This study shows that potassium and nitrate together reduce ammonium toxicity in rice roots by improving growth and correcting auxin distribution and cell morphology.

The paper describes a virtual summer program for high school students aimed at increasing diversity in AI through biomedical education, showing improved knowledge and engagement in AI concepts.

The paper develops a Bayesian-calibrated multiscale agent-based model to predict tumor growth using microscopy data, achieving reliable predictions with low error and standard deviation.

This paper shows fungal hyaluronic acid interacts with host CD44 to recruit autophagy proteins to phagosomes, promoting fungal internalization via a Ca2+ -CaMKKβ-AMPK-ULK1 signaling pathway.

This study shows that tumor-derived progranulin (PGRN) promotes immune evasion in pancreatic ductal adenocarcinoma by reducing MHC class I expression, and blocking PGRN enhances immune response and slows tumor progression.

This study shows sulfur limitation increases duckweed starch yield without reducing growth, making it a promising method for biofuel production.

This study examines how high light and high temperature affect photosynthesis in Setaria viridis, revealing distinct mechanisms and acclimation strategies in C4 plants.

This study identifies multiple SARS-CoV-2 spike protein sites susceptible to cleavage by cathepsins B, K, L, S, and V using computational and experimental methods.

This paper develops a mucosal RSV vaccine, P-KFD1, which protects mice against RSV infection without vaccine-enhanced disease and relies on CD4+ T cell responses mediated by IFN-γ or IL-17A.

This study optimizes a protocol to differentiate pluripotent stem cells into endothelial progenitor cells with characteristics similar to healthy donor EPCs, showing differences in gene expression compared to PAH-derived EPCs.

This paper investigates the increased transmissibility of the SARS-CoV-2 501Y.V1 variant due to the N501Y mutation in the Spike protein's RBD and its impact on ACE2 binding and vaccine efficacy.

This study uses DNA barcoding to track clonal evolution in breast cancer during metastasis and immunotherapy, finding ongoing immunoediting and identifying potential therapeutic targets.

This study shows that IL-13 signaling via STAT6 and KLF4 controls dermal DC2 differentiation and function, shaping a non-inflammatory, pro-allergic skin environment.

This study shows that IFNa-based combinations effectively inhibit SARS-CoV-2 infection in vitro and in vivo, with synergistic effects against other viruses.

This study determines the crystal structure of pDLA-88*001:01 and identifies its peptide-binding motif, revealing structural differences between two categories of DLA-88 alleles in dogs and their implications for antiviral immunity.

This study identifies that increased ketohexokinase-A promotes fructose-induced podocyte hypertrophy through activation of IL-6/STAT3 signaling.

This paper develops and evaluates deep learning models for automated leaf counting in maize and sorghum, achieving performance close to human annotators.

This study links CD44-/CD24- breast cancer cells to late-stage tumor recurrence and identifies RHBDL2 as a regulator of CSC conversion.

This study shows (p)ppGpp acts as a co-repressor of PurR in Firmicutes, downregulating purine synthesis by enhancing PurR DNA binding, with implications across environments from the gut to pathogens.

This paper introduces flimGANE, a deep learning method that rapidly and accurately generates FLIM images in low-photon conditions, outperforming traditional methods in speed and analysis accuracy.

This paper develops statistical tools for analyzing spatial rotations in 3D cryoEM using unit quaternions to enable comparisons, interpolations, and inference of rotations.

This study shows that ssc-miR-132 reduces inflammation and apoptosis in IPEC-J2 cells caused by C. perfringens beta2 toxin by targeting DACH1.

This study identifies LsAP2 as a transcription factor regulating seed shape in lettuce, showing its role in seed development and dispersal through interactions with LsBP and involvement in brassinosteroid pathways.

This study identifies ethacridine, an FDA-approved antiseptic, as a potent inhibitor of SARS-CoV-2 by inactivating viral particles in cellular models.