J. Yang

This paper develops a novel circular mRNA (C-RNA) platform for cancer therapy, showing it enhances anti-tumor immune responses and improves protein expression through optimized formulation.

The paper compares DNA and RNA microbial communities in Miscanthus x giganteus soil under different nitrogen fertilization rates, finding RNA-based communities better reflect nitrogen-cycling taxa.

This study shows that total parenteral nutrition (TPN) causes glucose metabolism disorders by altering gut microbiota and its metabolites, as demonstrated through human and mouse models.

This paper demonstrates optimal viral inactivation methods for SARS-CoV-2 and COVID-19 patient samples to enable safe handling at lower biosafety levels while preserving downstream assay fidelity.

This study uses first-principles calculations to show rutile TiO2 (110) nanosheets have strong adsorption for DNA nucleobases, exceeding graphene by over 20 times, with implications for DNA sensors and sequencers.

This study uses RADseq to analyze the phylogenetics of Sinocyclocheilus cavefishes, identifying six major clades, 19 known species, and two cryptic species, with recent diversification linked to geological events.

This paper shows metformin reduces anxiety and depression-like symptoms in mice during methamphetamine withdrawal by modulating gut microbiota-derived inosine.

This study investigates how genome divergence and compatibility contribute to the stabilization of hybrid genomes in an allopolyploid plant species.

This paper introduces two methods for rapid, small-scale cell surface biotinylation using tethered enzymes, enabling surface proteome analysis of cells and exosomes with high coverage and quantification of 1,020 surface proteins.

This study shows KMT2D loss in HNSCC leads to enhancer reprogramming and immune microenvironment changes, promoting tumor growth through interferon signaling disruption.

This study identifies ACKR3 as a driver of colorectal tumorigenesis by perturbing rRNA biogenesis through β-arrestin-1-mediated interactions.

This study compares inbreeding depression in maize and teosinte, finding greater depression in maize due to polygenic small-effect recessive variation and reduced large-effect variants after domestication.

The paper compares vaccine efficacy against Delta and Lambda SARS-CoV-2 variants, finding Lambda has greater escape potential, with reduced antibody reactivity and therapeutic antibody binding.

This study identifies PixR as a novel activator of IncX4 plasmid conjugation, showing it reduces the fitness cost of mcr-1 carriage in E. coli.

The paper shows that disordered spring climate disrupts migration and breeding of a short-distance fish, leading to population decline and larval flux reduction.

The paper identifies non-reproducible antibody-antigen interactions in clinical sera and develops a model to explain them, improving serological testing for viral infections like COVID-19.

The paper develops a sensitive and specific real-time PCR assay for detecting novel-goose parvovirus in vitro and in vivo, showing high sensitivity and reproducibility.

This study shows that exosomal miR-328 from lung adenocarcinoma cells promotes osteoclastogenesis by targeting Nrp2 and suggests its inhibitors as a potential treatment for bone metastasis.

This study shows thiol-based mucolytics inhibit SARS-CoV-2 by disrupting disulfides in the spike protein, reducing ACE2 binding and viral infection.

The paper measures forces during clathrin-mediated endocytosis in fission yeast using new in vivo force sensors, revealing force redistribution across the endocytic machinery.

This paper evaluates CDCP1 as a target for radioligand therapy in mCRPC, showing its expression in most biopsies and demonstrating antitumor effects with 177Lu-4A06.

This paper introduces SNU-seq, a method for single-nucleotide uracil mapping in DNA, validated on synthetic DNA and mammalian genomes, revealing uracil dynamics in treated cells and AID hotspots.

The paper identifies pathogenic neutrophilia as a driver of acute respiratory distress syndrome in severe COVID-19 patients, highlighting IL-8/CXCR2-mediated neutrophil recruitment and hyperinflammation.

This study uses UAV-based phenotyping to analyze maize nitrogen responses over time, identifying genetic regions and candidate genes associated with phenotypic traits.

This study examines how temperature affects the behavior and molecular responses of Neptunea cumingii, showing significant physiological and transcriptomic changes outside the optimal temperature range of 8–16°C.

The paper identifies a novel binding site on α-tubulin and shows that cevipabulin binding to this site induces tubulin degradation.

This paper develops a Cas13a-based assay for detecting Neisseria gonorrhoeae and identifying azithromycin resistance mutations, showing high sensitivity and concordance with existing methods.

This study develops an AAV-ie-S1 vaccine that neutralizes SARS-CoV-2 variants B.1.1.7 and B.1.351, offering protection against emerging strains.

The paper identifies SMR4 as a cyclin-dependent kinase inhibitor that decelerates the cell cycle during the transition from asymmetric to symmetric divisions in plant stomatal lineage.

This study develops an IFN-armed RBD dimer vaccine that induces strong neutralizing antibodies and T cell responses, offering complete protection against SARS-CoV-2 in rhesus macaques with a single dose.