J. Zhou

This study shows SARS-CoV-2 infection causes temporary olfactory dysfunction in mice by targeting olfactory epithelium cells and disrupting their structure and function.

This study uses atomistic simulations to investigate G4-hemin interactions, revealing dynamic binding mechanisms and suggesting hemin's role in G4 folding.

This study estimates heritability and genetic correlations of floral traits in Silene stellata using a linear mixed model and genealogy from molecular markers, finding significant heritability and positive genetic correlations.

This study examines the metabolome and cytokinome of follicular fluid in poor ovarian responders with and without DHEA supplementation, finding significant differences in metabolites and cytokines between groups.

The paper determines the structure of the HIV Gag six-helix bundle using cryoET and identifies small molecules stabilizing the immature lattice.

This paper introduces a method to model higher-order genetic interactions from partially observed data and applies it to predict phenotypes in antibody-binding domains and splicing efficiency.

This study shows that postharvest handling affects tomato fruit DNA methylation and quality, with chilling altering methylation and quality traits more than ripening stage.

This study shows the furin cleavage site in SARS-CoV-2 spike protein enhances replication in airway cells, contributing to transmission efficiency.

The paper evaluates the fitness of baloxavir-resistant influenza A viruses in ferrets, finding reduced within-host fitness for A/H3N2 I38T and lower between-host fitness for A/H1N1pdm09 I38T compared to wild-type viruses.

The paper identifies JIB-04 as a broad-spectrum antiviral that inhibits SARS-CoV-2 replication and coronavirus pathogenesis in vitro and in vivo.

This study examines virulence evolution in multiple infections of fungal pathogens with different transmission modes in a natural plant system, finding that vertical transmission correlates with decreased virulence while horizontal transmission correlates with increased virulence.

This study identifies Avr1d as a Phytophthora sojae effector that inhibits GmPUB13 E3 ligase activity by competing with E2 ubiquitin conjugating enzymes, stabilizing the susceptibility factor and facilitating infection.

The paper introduces a framework to quantify microbial community assembly mechanisms in grassland soils under warming, finding homogeneous selection and drift dominate, with warming altering their relative contributions.

The paper identifies Tom70's role in recruiting cytosolic chaperones to the mitochondrial outer membrane to mitigate proteotoxicity from hydrophobic precursor proteins.

This study shows EPAC1 regulates vWF secretion from endothelial cells during inflammation via the PI3K/eNOS pathway, with implications for thrombosis control.

This study shows favipiravir-resistant influenza A virus can transmit in ferrets but may lose its resistance mutation in vivo due to fitness trade-offs.

This study shows Noc prevents FtsZ protofilaments from migrating between Z-rings in B. subtilis, stabilizing cytokinesis without controlling division site selection.

The paper describes a pipeline for generating 3D molecular atlases of human kidney biopsies using multi-OMICS and imaging technologies, emphasizing quality control and reproducibility across institutions.

This study classifies bladder cancer patients into immune and non-immune groups using NMF and NTP algorithms, finding immune-activated patients respond better to anti-PD-1 therapy.

The paper assesses how environmental variables influence soil microbiomes in Barossa Valley vineyards and links microbial differences to grape and wine traits.

This paper identifies and engineers multivalent human VH domains that neutralize SARS-CoV-2 by targeting distinct epitopes on the Spike protein's ACE2 binding interface, showing increased affinity and potency.

This study shows an inactivated SARS-CoV-2 vaccine induces neutralizing antibodies and CTL responses in rhesus macaques, effectively preventing viral replication and lung inflammation.

This study integrates multi-omic data from COVID-19 patients to identify immune response patterns linked to disease severity.

The paper identifies an alpha helix on B-Raf critical for its interaction with MEK and oncogenic activity, suggesting it as a potential drug target for melanoma treatment.

This study shows luteolin alters BMDM polarization by modulating STAT1/6 pathways, reducing pro-inflammatory factors and increasing anti-inflammatory ones.

The paper investigates how synergistic epistasis enhances cooperativity in mutualistic interspecies interactions between Desulfovibrio vulgaris and Methanococcus maripaludis under varying sulfate conditions.

This study shows that Fis1 is not essential for mitochondrial fission in Plasmodium falciparum, suggesting the presence of other fission adaptor proteins.

This paper develops a rapid, low-cost method to detect and quantify SARS-CoV-2 virus particles using nanoplasmonic sensors in microplate readers and smartphone devices.

This study analyzes lipidomic and metabolomic profiles of Coffea canephora genotypes to understand their diversity and relationships.

This paper improves RosettaAntibody and Rosetta SnugDock by simplifying interfaces, expanding templates, and enhancing docking accuracy through benchmarking.