J. Zhou

This paper introduces a chemogenetic switch for CAR-T cells using HCV-NS3 protease, enabling controlled activation through ASV concentration modulation.

The paper identifies spike mutations that adapt SARS-CoV-2 to mustelid hosts and assesses their impact on human infectivity and antigenicity.

The paper establishes a bacterial genome and culture collection of the piglet gut microbiome, revealing new species and functional insights.

This study compares MRSA populations from Chinese pig farms and hospitals, finding distinct human and animal lineages with different genetic features and no evidence of spillover from farms to humans.

This study shows BTKi treatment reduces APOBEC3 expression in CLL B cells through enhancer regulation, linking BCR signaling to genomic instability.

The paper develops antibodies targeting proteolytic neo-epitopes of CDCP1 in RAS-driven cancers, showing improved tumor specificity and safety.

This study identifies MmcA as a key outer-surface c-type cytochrome for DIET in M. acetivorans and shows that archaella and other membrane complexes are involved in electron processing for methane production.

This study identifies molecular subtypes of prostate cancer using multi-omics data and clustering algorithms, revealing distinct clinical and biological features associated with each subtype.

This study identifies OsK5.2, an outward K+ channel, as a key determinant of rice salt tolerance by facilitating K+ translocation and reducing Na+ accumulation in leaves.

This study shows SARS-CoV-2 B.1.617 variants have enhanced spike cleavage by furin due to the P681R mutation, potentially increasing transmissibility and pathogenicity.

This study demonstrates that a natural microbial community can sustain nitrate removal from groundwater even after prolonged absence of an electron donor.

The paper elucidates the dideoxygenation mechanism in gentamicin biosynthesis, showing how intermediates JI-20A and JI-20B are converted to gentamicin C complex through phosphorylation and PLP-dependent enzymatic reactions.

This study evaluates the replication, antibody sensitivity, and vaccine efficacy of the SARS-CoV-2 B.1.617.2 Delta variant compared to other variants and vaccine-elicited immunity.

This study uses optical tweezers and molecular dynamics to analyze the mechanical unfolding kinetics of yeast tRNAphe, revealing how structural features influence folding and the role of tertiary interactions in unfolding cooperativity.

This study shows that MG53 reduces neuromuscular junction loss and extends survival in ALS by protecting diaphragm muscle and NMJ integrity.

This study compares gut microbiota composition between officials in a stable environment and train drivers in a dynamic environment, finding differences in diversity and functional predictions.

The paper defines and extends the near-infrared biological window for improved in vivo fluorescence imaging, proposing new regions and demonstrating enhanced imaging capabilities.

The paper develops a PD-L1 and TLR7 dual-targeting nanobody-drug conjugate that synergistically activates innate and adaptive immune responses, showing potent antitumor effects in both 'hot' and 'cold' tumors.

This paper identifies a human monoclonal antibody that broadly neutralizes SARS-CoV-2 variants and zoonotic sarbecoviruses by targeting a conserved epitope on the spike protein.

This study identifies antibodies against SARS-CoV-2 that balance neutralization potency and breadth, with some showing high resistance to viral escape.

This study identifies membrane lectins that enhance SARS-CoV-2 infection and show how different antibodies neutralize infection through distinct mechanisms.

This paper evaluates the in vitro and in vivo efficacy of dual-action monoclonal antibodies VIR-7831 and VIR-7832 against SARS-CoV-2, showing potent neutralization and reduced viral load in a hamster model.

This study shows that SARS-CoV-2 variant B.1.1.7 does not replicate better in airway cells or escape antibodies, suggesting its increased transmissibility is due to other factors.

This study develops a functionalized ECM scaffold with LXW7-DS-SILY to enhance neovascularization and diabetic wound healing in ZDF rats.

The paper shows that the vasopressin V2 receptor activates multiple G proteins and that its signaling can be biased by ligand structure.

The paper identifies a conserved antigenic supersite on the SARS-CoV-2 N-terminal domain recognized by neutralizing antibodies and shows its vulnerability to mutations in variants.

This study identifies that increased ketohexokinase-A promotes fructose-induced podocyte hypertrophy through activation of IL-6/STAT3 signaling.

The paper analyzes ARG hosts in WWTPs using metatranscriptomics, finding 45% of genomes express multi-antibiotic resistance genes, with pathogens and denitrifying bacteria as key hosts.

This study develops upconversion nanoparticles to monitor mitochondrial temperature dynamics in living cells and shows distinct thermal responses to various stimuli.

The study examines gut bacterial communities in cane toads across their invasive range and finds associations with host ecology, behavior, and parasite infection.