K. Liu

This study presents a synthetic ECM with high-affinity integrin-selective peptides that promote rapid stem cell spreading compared to traditional RGD or Matrigel controls.

The paper uses coevolution analysis and deep learning to model core eukaryotic protein complexes in yeast, identifying 104 new assemblies and structurally characterizing 608 previously unknown complexes.

This study extracts and purifies β-2,7,11-cembratriene-4,6-diol from tobacco leaves and demonstrates its antiviral activity against TMV through in vivo and molecular assays.

The paper identifies oxalic acid as a ligand for the brown planthopper's gustatory receptor Gr23a, showing it inhibits feeding and is sensed by the receptor.

This study models protein corona formation on LNPs and identifies time-dependent steps that affect their uptake and mRNA delivery, showing that pre-incubation in serum can eliminate a lag-time.

This study uses iTRAQ-based proteomics to identify cold stress-responsive proteins in japonica rice seedlings, finding 289 regulated proteins involved in photosynthesis and metabolism.

The paper presents the cryo-EM structure of ChRmine, revealing unique architectural features and provides insights into its conduction mechanism and potential for optogenetic applications.

This paper shows that oxidative phosphorylation (OXPHOS) generates most ATP in mouse ESCs and is essential for pluripotency by coupling with the hexosamine biosynthesis pathway to produce UDP-GlcNAc.

This study shows thiol-based mucolytics inhibit SARS-CoV-2 by disrupting disulfides in the spike protein, reducing ACE2 binding and viral infection.

The paper compares the tumor-repressing effects of TCF11 and Nrf1, showing TCF11 is more potent, while both have similar regulatory profiles distinct from Nrf2.

This study investigates the differential and cooperative roles of Nrf1 and Nrf2 in regulating antioxidant gene expression and cytoprotective responses to tBHQ-induced oxidative stress in human cell lines.

This study shows a single-dose AAV-based vaccine induces long-lasting neutralizing antibodies against multiple SARS-CoV-2 variants in rhesus macaques.

This study shows a single intranasal vaccination with inactivated Acinetobacter baumannii rapidly protects mice against pneumonia by training alveolar macrophages, with effects observed against other Gram-negative bacteria but not Gram-positive ones.

This study compares gut microbiota composition between officials in a stable environment and train drivers in a dynamic environment, finding differences in diversity and functional predictions.

This paper discovers CIPS nanosheets that selectively bind SARS-CoV-2 spike protein, inhibit viral entry, and promote macrophage-mediated viral elimination.

This study isolates and characterizes Helcococcus ovis from clinical bovine mastitis in China, showing its antimicrobial sensitivity and pathogenic potential in a murine model.

This study identifies IDH2 as a targetable regulator of drug resistance in CML by analyzing proteomic changes in resistant K562 cells.

This study shows oxaliplatin-resistant colorectal cancer cells become more sensitive to TRAIL due to increased DR4 expression, palmitoylation, and lipid raft localization.

The paper identifies reduced ER-mitochondria contacts as a mechanism promoting neuroblastoma multidrug resistance by impairing Ca2+ transfer and apoptosis.

This study shows that HIV-1 signal peptide diversity affects Env glycosylation and antibody recognition of V1V2 epitopes.

This study introduces a multi-enzyme directed evolution model to improve screening throughput and efficiency, revealing convergent evolution in two cytochrome P450 enzymes with distinct active sites achieving similar functions.

This study combines CRISPR activation and binary colloidal crystals to enhance the rapid differentiation of human iPSCs into neurons.

This study shows that pharmacologically lowering amino acid pools in yeast extends lifespan by inhibiting TORC1 signaling through sphingolipid-dependent mechanisms.

This study shows mosquito defensin enhances JEV infection by promoting virus adsorption and down-regulating an antiviral protein.

This study uses scRNA-seq to show that LIT induces proinflammatory cytokine signaling and immune cell activation in tumor microenvironments of MMTV-PyMT mice.

The paper determines the cryo-EM structure of MgtE in Mg2+-free conditions, revealing cytoplasmic pore opening and kink motions in TM2 and TM5 helices.

The paper models how motor activity and crosslinks generate dynamic nuclear structure and chromosome motions.