K. Zhang

This study identifies circRNAs in Asian honey bee midguts infected with Nosema ceranae and shows their role in regulating immune responses through miRNA targeting and pathway involvement.

This study investigates how sphingolipids in Leishmania major protect ergosterol from sterol-binding toxins, showing that ceramide reduces toxin cytotoxicity and enhances amphotericin B efficacy.

The paper identifies G42 as a lysosomal calcium mobilizer that inhibits autophagy and viral infections by alkalizing lysosomal pH and blocking autophagosome-lysosome fusion.

This paper develops a self-catalyzed system to produce stable, low-immunogenic circRNAs for therapeutic protein expression, showing improved efficacy compared to linear mRNAs.

The paper identifies a dominant negative mutation that stalls anthrax protective antigen pore maturation at an intermediate state, revealing structural features and a regulatory mechanism for pore formation.

The paper uses 2DTM to classify 60S ribosome maturation intermediates in yeast cells by analyzing their signal-to-noise ratios in cryo-EM micrographs.

This study determines the structure of the chikungunya virus replication complex at near-atomic and subnanometer resolution, revealing its molecular architecture and implications for antiviral therapy.

The paper presents cryo-EM structures of Chlamydomonas reinhardtii central apparatus and its dynamic conformational behavior, revealing how it regulates ciliary beating.

The paper develops a method to determine high-resolution structures of large microtubule-based motors by removing tubulin-lattice signals from cryo-EM data without requiring microtubule reconstruction.

This paper develops two new strategies for constructing large variant DMS libraries in mammalian cells using piggyBac-mediated genomic integration and in-vitro ligation.

This paper introduces a topological supramolecular network strategy to create highly conductive and stretchable organic bioelectronics with unprecedented performance in physiological environments.

This paper develops a wireless smart bandage that monitors wound conditions and delivers electrical stimulation to accelerate tissue regeneration in chronic wounds.

This study determines cryogenic-electron microscopy structures of active and inactive TSHR, revealing how autoantibodies and TSH activate the receptor through similar conformational changes.

This paper introduces a nanopore-based readout method for DNA strand displacement circuits, achieving higher output bandwidth than fluorescence spectroscopy for molecular diagnostics.

The paper explores fusion protein strategies to improve cryo-EM structure determination of GPCRs without signaling proteins, achieving resolutions of 3.4 and 3.7 Å for two receptors.

This study identifies changes in small non-coding RNAs (sncRNAs) in SARS-CoV-2 infection, showing that tRFs and a viral-derived sncRNA (sv-CoV2-346) are significantly altered.

The paper investigates how intramolecular epistasis affects the evolution of CTS-resistant Na,K-ATPases, finding that resistance substitutions have pleiotropic effects independent of sequence divergence.

This study shows that CD147 antibody inhibits SARS-CoV-2 infection and cytokine storm in variants by blocking viral entry and reducing inflammatory responses.

This study shows that m6A modifications regulate intestinal immunity and rotavirus infection by modulating IRF7 and IFN expression through METTL3 in intestinal epithelial cells.

This study shows that BHMT deletion in mice leads to homocysteine-induced ER stress and CREBH activation, increasing FGF21 which causes adipose browning and atrophy.

This study investigates the cardiac electrophysiological effects of hydroxychloroquine and azithromycin, showing they prolong QT intervals and increase arrhythmia risk when combined.

This paper introduces As-BDA, a method that detects and quantifies rare mutations down to 0.01% VAF using qPCR, with high concordance compared to ddPCR.

This paper identifies the molecular mechanism of Jin Ning Fang's anti-lung cancer effect using network pharmacology and experimental validation, revealing key targets and compounds involved.

The paper identifies stress-responsive small RNAs in Mycobacteria, finding some are linked to lipid metabolism and virulence.

This study identifies how Mycoplasma ovipneumoniae evades alveolar macrophage clearance by altering apoptosis, phagosome maturation, and autophagy in sheep.

This paper develops a machine learning model using Raman spectroscopy to accurately identify viruses, achieving high accuracy in classifying virus types and subtypes.

The paper shows that stress-induced ubiquitination is essential for recovery of cellular activities following heat stress.

This study identifies METTL9 as a tumor-promoting methyltransferase that methylates zinc transporters, disrupting zinc homeostasis and promoting cancer growth.

The paper analyzes the genome of the estuarine oyster to show how climate history and physical forces shape genomic diversity and adaptive plasticity through gene expansion and regulatory selection.

This study shows that HDAC5 deacetylates IFIT2, promoting glioma stemness and progression by inducing IFIT2 ubiquitination and loss of anti-tumor activity.