L. Li

The paper studies DNA bridge organization in adhesion domains using a model system, finding coexisting long and short DNA constructs despite length differences.

This study shows that high concentrations of 20-hydroxyecdysone induce cleavage of RhATG5, promoting the transition from autophagy to apoptosis in tick salivary glands.

This study identifies genes critical for different stages of Rhizobium-legume symbiosis using INSeq, showing 603 genes are required for nodulation and N2 fixation, with 146 shared across stages.

sPepFinder identifies small proteins in bacteria using sequence features and machine learning, achieving high accuracy and discovering thousands of novel small ORFs.

The paper investigates plant THI4 enzymes, finding that some are suicidal while others are catalytic, with implications for thiamin synthesis and energy efficiency.

The paper compares extracellular vesicles from cardiosphere-derived cells and mesenchymal stem cells, finding differences in miR composition that distinguish their origins.

The paper shows that proliferation in kidney cells reduces energy availability, leading to cell death and chronic kidney disease under metabolic stress.

This paper isolates blocking antibodies against SARS-CoV-2 RBD using a competitive biopanning strategy, identifying a high-affinity antibody with potent neutralizing activity.

This study shows that endothelial basement membrane laminins 411 and 511 influence monocyte differentiation to macrophages by modulating migration and integrin profiles.

The paper identifies SLC46A2 as the primary cGAMP importer in human monocytes and macrophages, revealing its role in cGAMP sensing and potential therapeutic applications.

This study examines the effects of dietary Citrus reticulata 'Chachi' products on the fecal microbiome of weaned piglets using multi-omics analyses, showing changes in microbial diversity, SCFAs, and proteomic profiles.

This study identifies that avian influenza A viruses with specific tissue tropisms in swine upper respiratory tracts can spill over to pigs, increasing the risk of viral adaptation and reassortment.

CoV Genome Tracker tracks SARS-CoV-2 genomic changes using haplotype networks and provides evolutionary rates to support pandemic response.

The paper investigates how β-alanine and L-carnosine affect pork quality by modulating glycolysis and AMPK activity in porcine muscle.

The paper shows that inhibiting nonsense-mediated decay increases expression of p53β/γ isoforms, which are resistant to MDM2 degradation, thereby restoring p53 function in cancers with MDM2 amplification, HPV infection, or specific p53 mutations.

The paper analyzes urine proteome changes in α-synuclein transgenic mice to identify proteins associated with Parkinson's disease progression.

The paper identifies differential proteins in urine of tumor-bearing mice, showing early biomarker potential for melanoma and prostate cancer.

The paper identifies metabolic subtypes of colorectal cancer using metabolomics and finds correlations between these subtypes and clinical outcomes.

This study analyzes plastome sequences from Gentianeae to show gene tree discordance and evolutionary rate heterogeneity among plastid genes, suggesting the need for more nuanced phylogenomic approaches.

The paper shows that inhibiting the integrin-TGF-β axis enhances NK cell function against glioblastoma stem cells, suggesting it as a therapeutic target.

This paper combines CIS checkpoint deletion with CAR engineering in NK cells to enhance their metabolic fitness and anti-tumor activity in a lymphoma model.

The paper determines the crystal structure of the MBTD1-EPC1 complex, revealing the molecular mechanism of MBTD1 recruitment into the NuA4/TIP60 acetyltransferase complex.

This study uses a nanoengineered cell niche to investigate how spatial positioning of activating and inhibitory ligands affects NK cell signaling, finding that a 40 nm gap optimally inhibits NKG2D signaling via KIR2DL1.

This study shows that intestinal epithelial cells preferentially respond to type III IFN, leading to antiviral protection while minimizing TNFα-induced toxicity.

The paper identifies CYCA3;4 as a target of the APC/CCCS52A2 E3 ligase in Arabidopsis, showing its timely breakdown post-prophase is essential for meristem organization and development.

This study shows that LIF alone can reprogram 2i/LIF cultured ESCs to hypermethylated ESCs, demonstrating DNA methylation's essential role in LIF-dependent reprogramming and self-renewal.

This study reports cryo-EM structures of a P4-ATPase lipid flippase in lipid bilayers, revealing mechanisms of lipid transport and ATP coupling.

This study identifies mitochondrial complex II disruption in intestinal epithelial cells as a key driver of T-cell mediated intestinal immunopathology across multiple disease models.

RapidAIM screens xenobiotics against individual microbiomes using metaproteomics, showing compound effects on abundance, composition, and functional pathways across individuals.

This study profiles the 2-hydroxyisobutyrylome in common wheat, identifying Khib modification sites and their roles in metabolic pathways and enzyme regulation.