L. Li

This study finds that severe SARS-CoV-2 infection is associated with stronger antibody and memory B cell responses against the spike protein and nucleocapsid protein.

This study identifies a linear epitope on SARS-CoV-2 S-RBD recognized by a potent neutralizing antibody and shows its potential for vaccine design.

The paper establishes principles of organelle membrane bridging using DNA tether mimics in GUV and SLB systems, showing adhesion driven by entropic effects rather than enthalpic binding.

The paper profiles longitudinal single-cell immune responses in asymptomatic COVID-19 patients and identifies distinct innate immune features associated with asymptomatic disease.

This study identifies the secondary ossification center's role in protecting growth plate hypertrophic chondrocytes from mechanical stress during terrestrial adaptation.

This paper develops a computer vision tool to automate detection of zebrafish behavioral changes in response to ambient odor using deep learning with minimal expert supervision.

This paper analyzes B cell epitopes of SARS-CoV-2 spike protein variants to assess their impact on antigenicity and vaccine efficacy.

This paper introduces a rapid screening system to identify potent neutralizing antibodies against SARS-CoV-2 and demonstrates its effectiveness in discovering high-potency antibodies.

This study combines proteomics and Mendelian randomization to identify aspirin-targeted proteins associated with reduced colorectal cancer risk.

This study shows that human lung organoids can model SARS-CoV-2 infection and drug response, revealing virus targets and effective antiviral treatment.

This study shows that obesity increases organ size, which correlates with higher cancer risk due to more cells at risk of becoming cancerous.

This study uses a zebrafish model of granulin deficiency to show granulin's role in myeloid cell differentiation and wound healing.

The paper identifies four dominant mutations, three significant multi-site co-mutations, and a 5'UTR CpG escape mutation that drive the rapid evolution of SARS-CoV-2.

The paper identifies a PIF1-MIR408-PLC repression cascade that links light-induced PIF1 degradation to hormonal changes, regulating seed germination in Arabidopsis.

This study integrates proteomic data from human and mouse macrophages to analyze posttranslational modifications in the inflammatory response, identifying PTM crosstalk and novel inflammatory proteins.

This study shows hESCs-derived lung organoids can reconstruct human airway epithelium in vivo, with CD47high cells enhancing ciliated cell generation and epithelial thickness.

This study identifies gene expression changes and pathways involved in passion fruit ripening and senescence using RNA sequencing and validates findings with RT-qPCR.

This study uses quantitative proteomics to show ESD reduces inflammation and modulates immune response in OA, protecting joints and cartilage.

This study shows that SETD2 deficiency disrupts the β-catenin destruction complex, promoting ccRCC formation, and links SETD2-mediated H3K36me3 to Wnt/β-catenin signaling in renal cancer.

This study investigates the role of ESR1-CCDC170 gene fusions in breast cancer endocrine resistance, showing they reduce endocrine sensitivity and can be targeted with HER2/SRC inhibitors.

This paper identifies Bl-Eng2 as an adjuvant that enhances cell-mediated immunity against fungal and viral infections through structural and mechanistic insights.

This paper presents a chromosome-level genome assembly and annotation of Magnolia biondii, revealing insights into its evolutionary history and gene function.

The paper shows extracellular histones cause disseminated intravascular coagulation (DIC) via tissue factor-dependent lytic cell death, independent of inflammasome or TLR pathways.

This study identifies COUP-TFII as a driver of myofibroblast metabolic shift to aerobic glycolysis, promoting fibrosis in multiple organs.

This study shows BMPER deficiency leads to insulin resistance and hyperglycemia, and BMPER therapy improves these conditions in mice.

This study investigates how the gut microbiome changes in mice after colonization with vancomycin-resistant Enterococcus faecium, identifying metabolite associations linked to bacterial shifts.

This paper develops a deep learning model to detect cancer regions and estimate PD-L1 tumor proportion scores in lung adenocarcinoma IHC slides, showing strong agreement with pathologists' interpretations.

This study develops small molecule ENPP1 inhibitors with sub-nanomolar potency and demonstrates their efficacy in delaying tumor growth in a breast cancer model.

The paper identifies and characterizes small proteins in Salmonella Typhimurium using integrated omics data, revealing a new role for MgrB in virulence and motility.

The paper uses CRISPR/Cas9 to study alkaline phosphatase isoforms and their regulatory network in diatoms, revealing their functional differences and compensatory roles in phosphorus scavenging.