L. Li

This study examines how different types of resistant starches affect gut microbiome protein expression and functional pathways, revealing inter-individual variations in responses.

This study identifies B- and T-cell epitopes from SARS-CoV-2 surface glycoprotein using immune-informatics approaches, confirming their antigenicity and compatibility with HLA alleles for potential vaccine development.

This study identifies EP2 as a key PGE2 receptor promoting neuroblastoma growth and shows that targeting it with small-molecule antagonists inhibits tumor growth in mice.

The paper identifies LRRC8A:C as a cGAMP transporter in human vasculature cells and shows it mediates cGAMP import/export and is the dominant importer in these cells.

This study uses transcriptomics to show that manuka honey's antimicrobial action involves multiple mechanisms, including SOS response, oxidative damage, and membrane disruption, without promoting bacterial resistance.

This study uses single mosquito metatranscriptomics to identify vectors, emerging pathogens, and reservoirs in one assay, detecting known and novel viruses and linking pathogens to blood meal sources.

This study shows that recombinant human MG53 protein protects cardiomyocytes from ischemia-reperfusion-induced oxidative stress by preserving mitochondrial integrity.

This study shows that metformin affects in vitro gut microbiota differently depending on when it is added during growth phases, with the log phase showing the strongest impact on growth and functional changes.

The paper analyzes H5N1 influenza virus evolution in humans and ducks in Cambodia, finding human-adapting mutations but limited within-host evolution due to selection pressures.

This study identifies and validates a core regulatory circuitry trio in Ewing sarcoma, showing how EWS-FLI1 and CRC factors regulate transcription and epigenome, with implications for therapy.

This study shows that Fusobacterium nucleatum binding and invasion of colorectal cancer cells induces IL-8 and CXCL1 secretion, promoting cancer cell migration and immune signaling.

This study shows that Nα-acetylation of Thr2 on EsxA is necessary for its dissociation from EsxB and subsequent mycobacterial virulence.

This study shows that CTR9 loss in breast cancer cells increases H3K27me3 levels and switches PRC2 subtype, making cells more sensitive to PRC2 inhibitors.

The paper proposes the 'Mitochondrial Fostering' theory, suggesting mitochondrial genomes contribute to the evolution of orphan genes in land plants through DNA transfer and recombination.

The paper analyzes the intestinal stem cell niche by combining bulk RNA sequencing and scRNA-seq to identify a network of cell types and signals involved in ISC regulation.

This paper describes the generation of dual-specific bivalent BiTES for cancer immunotherapy, showing they maintain tumor targeting and kill CEA+ cells in vitro and in vivo.

A vaccine targeting viral protease cleavage sites provides >80% protection against vaginal SIVmac251 infection in macaques by inducing T cell responses and a protective immune environment.

This paper reports crystal structures showing the stepwise displacement of the σ finger in bacterial transcription initiation factors driven by RNA extension during initial transcription.

This paper identifies aCPSF1 as the first general transcription termination factor in Archaea, revealing its cleavage-dependent termination mechanism and evolutionary relationship to eukaryotic processes.

The paper shows that stress-induced myonectin improves glucose homeostasis by inhibiting glycemic response to epinephrine and enhancing insulin sensitivity in adipose tissues.

The paper introduces GLAMS, a method using glycosyltransferase labeling and mass spectrometry to identify sialylation linkages at the glycopeptide level, successfully identifying 1,236 linkage-specific sialoglycopeptides from human serum.

The paper identifies fibroblast-expressed PIK3Cδ as a key driver of triple-negative breast cancer progression through paracrine signaling and shows its prognostic significance.

This study establishes a trans-resveratrol-induced mouse pulmonary fibrosis model and compares it to the bleomycin-induced model, finding it causes less damage and progresses more slowly.

This study optimizes fertigation for greenhouse strawberries by identifying the optimal levels of N, P, K, and water to maximize yield and SSC/TA ratio.

This study examines how substrate stiffness affects human umbilical vein endothelial cell behavior, finding increased CX40 and GAG content and decreased actin stress fibers and proliferation on stiff substrates.

The paper identifies extracellular 2’3’-cGAMP as an immunotransmitter released by cancer cells, regulated by ENPP1, and shows its therapeutic potential in tumor treatment.

This paper develops a framework to prioritize antibiotic resistance genes (ARGs) based on risk factors and identifies high-risk ARGs for global action.

This study evaluates a novel Brucella multiepitope recombinant protein as a diagnostic antigen for brucellosis, showing strong immunoreactivity and diagnostic accuracy in mice.

This study identifies urinary protein biomarkers for uveitis using DIA and PRM proteomics in an EAU rat model, finding 12 proteins significantly altered before clinical symptoms.