L. Zhang

The paper identifies non-reproducible antibody-antigen interactions in clinical sera and develops a model to explain them, improving serological testing for viral infections like COVID-19.

This study shows NSUN2-mediated m5C methylation of IRF3 mRNA reduces type I interferon responses by promoting IRF3 mRNA degradation, and NSUN2 levels decrease during viral infection to enhance antiviral immunity.

This paper introduces a photoredox-catalyzed method for C-terminal labeling of peptides, applicable to bulk and single-molecule proteomics, achieving over 50% labeling efficiency across proteomes.

This paper shows that oxidative phosphorylation (OXPHOS) generates most ATP in mouse ESCs and is essential for pluripotency by coupling with the hexosamine biosynthesis pathway to produce UDP-GlcNAc.

This paper presents a method for preserving and quantitatively measuring mitochondrial morphology in tissues and cultured cells without introducing artifacts.

The paper shows that PLK-2 inactivates CHK-2 in C. elegans to promote crossover formation and meiotic progression after synapsis.

This study shows that overexpressing SIRT5 protects against cardiac dysfunction and fibrosis in response to pressure overload in mice.

This study shows that BiTE-secreting T cells outperform CAR T cells in killing glioma cells in vitro and in vivo, with enhanced cytotoxicity and tumor growth delay.

This study identifies uridine as a novel nutrient for pancreatic cancer cells through uridine phosphorylase 1, showing its role in survival and metabolism under glucose deprivation.

This study develops a molecular dynamic fingerprint (MDFP) and combines it with traditional fingerprints to predict hERG cardiotoxicity, achieving higher accuracy than single-fingerprint models.

The paper develops activity-based probes to analyze KLK activome dynamics in prostate cancer, revealing KLK14's role in migration and secretion into the bone microenvironment.

This study examines how nitrification inhibitors and straw incorporation affect N2O emissions and microbial communities in different cropland soils, finding that their effects vary by soil type.

The paper develops ATAC-Array, a low-cost chromatin accessibility assay, and shows it predicts pancreatic cancer prognosis based on chromatin accessibility patterns.

This paper develops a three-dimensional restricted visual field metric-free model to study swarm consistency and finds that optimal restricted angles improve flock cohesion compared to global visual fields.

This paper identifies the METTL5-TRMT112 complex as the methyltransferase responsible for m6A modification at 18S rRNA, linking it to metabolism and development.

This study investigates how specific amino acids in the DNA-binding domain of CcpA affect carbon source utilization in Bacillus licheniformis through in vitro and in vivo experiments.

The paper identifies a lipid-mTORC1 pathway regulated by peroxisome-derived hormones that controls development in C. elegans by modulating chemosensory neurons.

This paper assesses how mutations E484Q and L452R in SARS-CoV-2 variant B.1.617 affect binding to the antibody Bamlanivimab using molecular dynamics and deep learning.

This study introduces a bioorthogonal chemical reporter, Alk-4, to selectively label and study FASN-dependent protein acylation in cells and viruses.

This study uses long-read sequencing to show DNA methylation affects pre-mRNA splicing, poly(A) tail length, and gene silencing in Arabidopsis.

The paper uses spatial transcriptomics to analyze lung cancer heterogeneity, identifying gene expression gradients and tumor subclones, and infers metastasis trajectories through pseudo-time modeling.

This study identifies SRF3 as a receptor kinase that coordinates iron homeostasis and immune responses in plants by regulating callose synthase activity.

This study examines how long-term tea monoculture affects soil nutrient dynamics and bacterial communities across different stand ages.

This study identifies METTL9 as a tumor-promoting methyltransferase that methylates zinc transporters, disrupting zinc homeostasis and promoting cancer growth.

This study shows rapalogs like rapamycin increase SARS-CoV-2 infection by reducing antiviral proteins through microautophagy, while ridaforolimus has less effect.

The paper evaluates clustering methods for microbiome data, identifies scenarios where specific metrics underperform, and proposes a combined metric that improves performance across datasets.

This study isolates and characterizes Helcococcus ovis from clinical bovine mastitis in China, showing its antimicrobial sensitivity and pathogenic potential in a murine model.

The paper examines how non-structural carbohydrates (NSCs) and fine root traits vary across root branch orders in Fraxinus mandshurica seedlings under different drought and soil conditions.

This study identifies unbalanced dietary patterns as contributors to precocious puberty by altering gut microbiota and host metabolites, with biomarkers showing high diagnostic accuracy.